World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 1: Update 2012 on the acute treatment of schizophrenia and the management of treatment resistance

These updated guidelines are based on a first edition of the World Federation of Societies of Biological Psychiatry Guidelines for Biological Treatment of Schizophrenia published in 2005. For this 2012 revision, all available publications pertaining to the biological treatment of schizophrenia were reviewed systematically to allow for an evidence-based update. These guidelines provide evidence-based practice recommendations that are clinically and scientifically meaningful and these guidelines are intended to be used by all physicians diagnosing and treating people suffering from schizophrenia. Based on the first version of these guidelines, a systematic review of the MEDLINE/PUBMED database and the Cochrane Library, in addition to data extraction from national treatment guidelines, has been performed for this update. The identified literature was evaluated with respect to the strength of evidence for its efficacy and then categorised into six levels of evidence (A-F; Bandelow et al. 2008b, World J Biol Psychiatry 9: 242). This first part of the updated guidelines covers the general descriptions of antipsychotics and their side effects, the biological treatment of acute schizophrenia and the management of treatment-resistant schizophrenia.

Contribution of transmembrane and cytoplasmic domains to membrane protein association

Membrane proteins are critical to every aspect of cell physiology, with their association mediating important biological functions. The transmembrane and cytoplasmic domains are known to be important for their association. In order to characterize their role in detail, we have applied different biophysical techniques in detergent micelles to two model systems. The first study involves FcRγ, a single transmembrane domain protein existing as a disulfide linked homodimer. We investigated the role of a conserved transmembrane polar residue and the cytoplasmic tail in FcRγ homo-interactions. Our results by various biophysical techniques including SDS-PAGE, circular dichroism and sedimentation equilibrium in detergent micelles indicate importance of both the transmembrane polar residue and cytoplasmic tail in maintaining proper conformation for FcRγ homo-interactions. A contrasting second study was on L-selectin, another single transmembrane domain protein with a large extracellular domain and a short cytoplasmic tail. Previous cross-linking experiments indicate its possible dimerization. However, the purified fragment of L-selectin and corresponding mutants did not dimerize when analyzed by TOXCAT assay, sedimentation equilibrium and fluorescence resonance energy transfer. It was likely that the presence of juxtamembrane positively charged residues led to decreased migrational rates in SDS PAGE. In conclusion, complementary biophysical techniques should be used with care when studying membrane protein association in detergent micelles. As an extension to our study on L-selectin, we also investigated its interaction with Calmodulin (CaM) in detergent micelles. CaM was found to interact with different detergents. We applied fluorescence and NMR spectroscopy to characterize the interaction of both the apo and Ca 2+ bound form of CaM, with commonly used detergents, below and above their respective critical micelle concentrations. The interaction of apo-CaM with detergents was found to vary with the nature of the detergent head group, whereas Ca2+-CaM interacted with individual detergent molecules irrespective of the nature of their head group. NMR titration experiments of CaM with detergents indicated involvement of specific residues from the N-lobe, linker and C-lobe of CaM. ^

Report of the general manager of railways.

1903 has appendix: Statement of revenue and expenditure and statistics of traffic of each station for the year ended 31st Decenber, 1903.

A critique of the theory of evolution,

Half-title: Princeton university. The Louis Clark Vanuxem foundation lectures for 1915-1916.

New criminal procedure: or, New commentaries on the law of pleading and evidence and the practice in criminal cases,

"The general rules of practice and procedure are treated in volumes I and II, while volume III is devoted wholly to procedure and evidence in various common law crimes."--Pref, to 2d ed.

An overview of psychological and neurobiological mechanisms by which early negative experiences increase risk of mood disorders

Objective: Early life experiences are associated with severe and long-lasting effects on behavioural and emotional functioning, which in turn are thought to increase the risk for unipolar depression and other disorders of affect regulation. The neurobiological and psychological mechanisms through which adverse early life experiences confer risk are poorly understood. Method: Alterations in brain structure and function in limbic and prefrontal cortical regions have been linked to early negative experiences and to mood disorders. Results: There are a number of psychological domains that may be dysfunctional in people with mood disorders, and which, if the dysfunction occurs prior to onset of mood symptoms, may signify a risk factor for depression. Cognitive dysfunction has been examined in patients with mood disorders, with some suggestion that changes in cognitive function may antedate the onset of mood symptoms, and may be exacerbated in those who experienced early negative trauma. Social cognition, including emotion comprehension, theory of mind and empathy, represent under-studied domains of psychological function that may be negatively influenced by early adverse experience. Temperament and personality factors may also leave people vulnerable to mood instability. Conclusion: This review summarizes the evidence for dysfunction in each of these domains for people with mood disorders.

Transformational leadership, innovative behavior and task performance:test of mediation and moderation processes

We use the self-concept based theory of leadership and social exchange theory to hypothesize processes linking transformational leadership to follower performance outcomes. Specifically, we hypothesize that (a) transformational leadership relates to followers' work engagement both directly and indirectly through their psychological states, (b) work engagement relates to innovative behavior, (c) innovative behavior relates to task performance, and (d) the work engagement–innovative behavior relationship is moderated by leader–member exchange. Results from a test of these relationships in a sample of employees of a large telecommunication company in China largely support our hypothesized model.

Bródy András gazdaságiciklus-elmélete (András Bródy's theory of economic cycles)

Bródy András kutatásainak egyik központi témaköre a gazdasági mozgás vizsgálata volt. Írásunkban Bródy elméletét kívánjuk röviden áttekinteni és összefoglalni. A termelés sokszektoros leírása egyben árelméletét (értékelméletét, méréselméletét) is keretbe foglalja. Ebben a keretben a gazdasági mozgás összetett ingadozása technológiai alapon elemezhető. Bródy megközelítésében a gazdasági ciklust nem külső megrázkódások magyarázzák, hanem a termelési rendszer belső arányai és kapcsolatai. A termelési struktúrát az árak és a volumenek egyformán alakítják, ezek között nincsen kitüntetett vagy domináns tényező. Az árak és a volumenek a köztük lévő duális kapcsolatban alakulnak ki. A gazdaság mozgásegyenleteit technológiai mérlegösszefüggések, valamint a piaci csere útján a gazdaságban újraelosztásra (újratermelésre) kerülő termékek felhasználása és az eszközlekötés változása írja le. Az így meghatározott mozgásegyenletek a gazdaság természetes mozgását ciklusmozgás alakjában írják le. A technológia vagy az értékviszonyok megváltozása (sokkok) a gazdaság ciklikus mozgásának megváltozásában tükröződik. Bródy munkáiban technológiai megalapozást nyer a történelemből ismert számos jellegzetes gazdasági ciklus. / === / Economic motion and dynamics are at the heart of Andras Brody's creative output. This paper attempts a bird's-eye view of his theory of economic cycles. Brody's multi-sector modelling of production has provided a framework for price theory (the theory of value and measurement). His theory of economic motion with cyclical characteristics is technology driven. It argues that the complex web of economic cycles is determined by the proportions and interrelationships of the system of production, not by arbitrary external shocks. The structure's behaviour are driven by prices and proportions, with the duality of prices and proportions as a dominant feature. These are features in common with the Leontief models, which Brody extended to economic cycles. Brody saw economic cycles as natural motions of economic systems with accumulated assets (time lags) and market exchange of goods (demand and supply adjustment). Changes in technology or valuations (shocks) are reflected in changing patterns of motion. His model of the economy is a fine instrument that enabled him to show how the technological parameters of its system determine the frequency and other characteristics of various economic cycles identified in economic history.

Algebraic theory of minimal nondeterministic finite automata with applications

Since the 1950s, the theory of deterministic and nondeterministic finite automata (DFAs and NFAs, respectively) has been a cornerstone of theoretical computer science. In this dissertation, our main object of study is minimal NFAs. In contrast with minimal DFAs, minimal NFAs are computationally challenging: first, there can be more than one minimal NFA recognizing a given language; second, the problem of converting an NFA to a minimal equivalent NFA is NP-hard, even for NFAs over a unary alphabet. Our study is based on the development of two main theories, inductive bases and partials, which in combination form the foundation for an incremental algorithm, ibas, to find minimal NFAs. An inductive basis is a collection of languages with the property that it can generate (through union) each of the left quotients of its elements. We prove a fundamental characterization theorem which says that a language can be recognized by an n-state NFA if and only if it can be generated by an n-element inductive basis. A partial is an incompletely-specified language. We say that an NFA recognizes a partial if its language extends the partial, meaning that the NFA’s behavior is unconstrained on unspecified strings; it follows that a minimal NFA for a partial is also minimal for its language. We therefore direct our attention to minimal NFAs recognizing a given partial. Combining inductive bases and partials, we generalize our characterization theorem, showing that a partial can be recognized by an n-state NFA if and only if it can be generated by an n-element partial inductive basis. We apply our theory to develop and implement ibas, an incremental algorithm that finds minimal partial inductive bases generating a given partial. In the case of unary languages, ibas can often find minimal NFAs of up to 10 states in about an hour of computing time; with brute-force search this would require many trillions of years.

Algebraic Theory of Minimal Nondeterministic Finite Automata with Applications

Since the 1950s, the theory of deterministic and nondeterministic finite automata (DFAs and NFAs, respectively) has been a cornerstone of theoretical computer science. In this dissertation, our main object of study is minimal NFAs. In contrast with minimal DFAs, minimal NFAs are computationally challenging: first, there can be more than one minimal NFA recognizing a given language; second, the problem of converting an NFA to a minimal equivalent NFA is NP-hard, even for NFAs over a unary alphabet. Our study is based on the development of two main theories, inductive bases and partials, which in combination form the foundation for an incremental algorithm, ibas, to find minimal NFAs. An inductive basis is a collection of languages with the property that it can generate (through union) each of the left quotients of its elements. We prove a fundamental characterization theorem which says that a language can be recognized by an n-state NFA if and only if it can be generated by an n-element inductive basis. A partial is an incompletely-specified language. We say that an NFA recognizes a partial if its language extends the partial, meaning that the NFA's behavior is unconstrained on unspecified strings; it follows that a minimal NFA for a partial is also minimal for its language. We therefore direct our attention to minimal NFAs recognizing a given partial. Combining inductive bases and partials, we generalize our characterization theorem, showing that a partial can be recognized by an n-state NFA if and only if it can be generated by an n-element partial inductive basis. We apply our theory to develop and implement ibas, an incremental algorithm that finds minimal partial inductive bases generating a given partial. In the case of unary languages, ibas can often find minimal NFAs of up to 10 states in about an hour of computing time; with brute-force search this would require many trillions of years.

Horse stable environment: what to expect regarding fungi and particles occupational exposure?

The simultaneous presence of fungi and particles in horse stable environment can create a singular exposure condition because particles have been reported has a good carrier for microorganisms and their metabolites. This study intends to characterize this setting and to recognize fungi and particles occupational exposure.

Absorption and luminescent excitation spectra of F and M centers in Kcl and NaF

Luminescent excitation spectra were measured for the F and M centers in KCl; in particular, for the F band, M band, and the M2 transition. In all 3 cases, the spectra were nearly double-Gaussian in shape, and the efficiency for luminescence was nearly independent of the wavelength of the exciting light. A comparison of the absorption spectrum with the excitation spectrum of the F-band region of crystals with M centers present and oriented provided further evidence for the existence of the M2 transition of van Doorn and Haven and of Okamoto, and against the energy transfer theory of Lambe and Compton. The efficiency for luminescence of the M center upon M-band excitation was equal to the efficiency for F centers in pulse-annealed crystals of low F-center concentrations. The ratio of the efficiencies of the Ml to M2 transitions was 1.2 ± .25. The oscillator strengths of 3 of the M-center transitions in KCl relative to the oscillator strength for the F center were found to be in better agreement with the results reported by Okamoto, than with the results reported by Delbecq. The polarization of luminescence of M centers in KCl was measured at right angles to the exciting light, and was found to agree with the predictions of the van Doorn-Haven model of the M center. In NaF crystals having no absorption bands to the red side of the M band, the absorption and excitation spectra of the M band were accurately double-Gaussian over a wide range of wavelengths; the efficiency of luminescence of the M center was independent of the wavelength of the exciting light in that range; and the polarization of luminescence upon M-band excitation agreed well with the calculations based on the van DoornHaven model of the M center, In crystals in which the F band was bleached sufficiently to make it smaller in absorption height than the M band, several new color centers appeared on the red side of the M band, in contrast to the results reported by Blum; in these crystals, the polarization of luminescence of the M center upon M-band excitation disagreed strongly with theory, even though the absorptions for the new color centers were small compared to the M-band absorption.

La construcción de la opinión pública desde la televisión privada en Colombia. 2002 - 2010

Considerando la estrecha relación opinión pública y democracia, en esta disertación se lleva a cabo un análisis socio-histórico de la construcción del campo de la televisión en Colombia, por ser el medio que mayor alcance tiene. Buscando generar un diagnóstico de la influencia actual de los dos mayores medios masivos de Colombia, RCN TV y Caracol TV sobre la opinión pública y la democracia, durante la última década. Con este propósito, se articulan la teoría de los campos y los habitus de Pierre Bourdieu con el Modelo de la Propaganda de Hermann y Chomsky, para poder determinar la cada vez más estrecha relación entre los poderes político y económico, con la producción del contenido audiovisual, especialmente informativo y de opinión. Encontrando, pruebas documentales y patrones de comportamiento que demuestran como las lógicas de las estructuras corporativas han logrado consolidar y sostener un oligopolio mediático nacional para su absoluto beneficio, no solamente en detrimento de la democracia, sino también, violando la constitución.

La Androergología: una nueva disciplina de la educación

A research work on the micro firms in Caroni district, has been developing since 1994. Such study pretends to deepen the theory that let the empiric- philosophical- conceptual and methodological building of a new discipline in education, called Androergology. The most outstanding aspects that can be seen from the philosophical bases are the following: its ontology, as aempowerment of the individual abilities through mental structures change in a community of pairs; ethics as the one based on the assignment of Good for the process of creatingsocioproductive communities_ which also means a liberating function since it can achieve a sustainable economic development by the assembling of micro firms nets; and the epistemology derived from the bases of the General Theory of Systems and the Morin’s circular complexities. Among the principles of this discipline that can be mentioned are ContinuingEducation- since the individual already belongs to a society that always creates knowledge, global markets - the undertaker should produce for a world society, the age of this microfirm’s man- as a discussion upon the knowledge production in that individual as an epistemic subject, the Integral Education- since the spiritual, social and humanistic aspects should beadded to the technical ones; and the Contextual Formation-since the process should take place into the unit of production. The androergologic methodology is thought out as a processof two inputs: the business needs diagnosis and the knowledge of context. The central part focuses its attention on the adult learning process situation; and the concentric circles whichmean the ideal synergical relationship between the programmatic contents, learning processes, the androergologist and the necessary supervising process, which results to be theintegral and innovating element of this method.