Friedreich Ataxia

Friedreich ataxia (FRDA) is an autosomal recessive disease characterized by progressive neurological and cardiac abnormalities. It has a prevalence of around 2×10⁵ in whites, accounting for more than one-third of the cases of recessively inherited ataxia in this ethnic group. FRDA may not exist in nonwhite populations.The first symptoms usually appear in childhood, but age of onset may vary from infancy to adulthood. Atrophy of sensory and cerebellar pathways causes ataxia, dysarthria, fixation instability, deep sensory loss, and loss of tendon reflexes. Corticospinal degeneration leads to muscular weakness and extensor plantar responses. A hypertrophic cardiomyopathy may contribute to disability and cause premature death. Other common problems include kyphoscoliosis, pes cavus, and, in 10% of patients, diabetes mellitus.The FRDA gene (FXN) encodes a small mitochondrial protein, frataxin, which is produced in insufficient amounts in the disease, as a consequence of the epigenetic silencing of the gene triggered by a GAA triplet repeat expansion in the first intron of the gene. Frataxin deficiency results in impaired iron-sulfur cluster biogenesis in mitochondria, in turn leading to widespread dysfunction of iron-sulfur center containing enzymes (in particular respiratory complexes I, II and III, and aconitase), impaired iron metabolism, oxidative stress, and mitochondrial dysfunction. Therapy aims to restore frataxin levels or to correct the consequences of its deficiency.

THE ASSOCIATION OF DEMOGRAPHIC VARIABLES AND DIETARY HABITS ON BODY MASS INDEX OF FOREIGN-BORN POPULATION IN SOUTH KOREA

The Republic of Korea (Korea) has been composed of a single ethnic group and, until very recently, has had little or no experience with large-volume of immigrants. The country, once known for its large-scale emigration, has emerged as a popular destination. As the foreign-born populations continue to grow, they experience dietary pattern changes. Dietary changes of immigrants are often associated with weight increase and consequently the risk of non-communicable diseases such as diabetes. This study examined the association of demographic variables and dietary habits on Body Mass Index (BMI) of foreign nationals living in Korea, based on a cross-sectional sample of 193 foreign-born men (120) and women (73). A web-based survey program, Zoho survey, was used to capture self-reported region of origin, socio-demographic variables, weight, height, frequency of physical activity, and food frequencies. For the entire sample (n=193), the World Health Organization (WHO) classification and the Korean Society for the Study of Obesity cut-off points of BMI were used. The average BMI was 24.6 (SD=3.6) kg/m2. Significant associations were observed between BMI and age (χ² (8, N=193) =26.22, p<.01), gender (χ² (2, N=193) =11.45, p<.01), and religious affiliation (χ² (4, N=191) =9.53, p<.05). On average, participants had meat and carbonated drinks 2.2 times a week; high calorie foods 1.5 times a week; and, dairy products 2.4 times a week. A significant correlation (r=.14, p<.05) between BMI and eating meat was also observed. This study showed that the BMI varied with age, gender and religion. Frequent consumption of meat was associated with a significant increase in BMI. This increase in BMI could be associated with the dietary changes experienced by the newcomers or absence of more familiar products. Consequently, as the volume of immigrants continues to increase in Korea, it is imperative to consider designing and implementing public health policies specifically in relation to a healthy diet that can impact the prevalence of preventable chronic diseases. Thus, health education among foreign-born population in Korea should focus on reducing the intake of meat and high energy foods.

El buglere: lengua obsolescente

El estudio plantea una caracterización general del buglere, dialecto del bocotá, perteneciente a la familia chibcha. Se aportan algunos datos de orden social y cultural asociados a la diáspora de la etnia, y posteriormente se centra en la caracterización tipológica de la lengua, que la vincula directamente con la familia mencionada. Señala su autor que el notable riesgo de extinción obliga a llevar a cabo estudios descriptivos sistemáticos y sostenidos, con la esperanza de propiciar su eventual revitalización.This study presents a general characterization of Buglere –a dialect of Bocotá, which belongs to the Chibcha family. It provides information on the social and cultural system related to the scattering of that ethnic group. Attention is then given to the typological characterization of the language, in which it is linked directly to the family mentioned. The author affirms that the significant risk of extinction is what leads to systematic, sustained descriptive studies, with the hope of eventually revitalizing the language.

Preeclampsia prevention: a case-control study nested in a cohort

Introduction: Preeclampsia is the main complication of pregnancy in developing countries. Calcium starting at 14 weeks of pregnancy is indicated to prevent the disease. Recent advances in prevention of preeclampsia endorse the addition of conjugated linoleic acid. Objective: To estimate the protective effect from calcium alone, compared to calcium plus conjugated linoleic acid in nulliparous women at risk of preeclampsia. Methods: A case-control design nested in the cohort of nulliparous women attending antenatal care from 2010 to 2014. The clinical histories of 387 cases of preeclampsia were compared with 1,054 normotensive controls. The exposure was prescriptions for calcium alone, the first period, or calcium plus conjugated linoleic acid, the second period, from 12 to 16 weeks of gestational age to labor. Confounding variables were controlled, allowing only nulliparous women into the study and stratifying by age, education and ethnic group. Results: The average age was 26.4 yrs old (range= 13-45), 85% from mixed ethnic backgrounds and with high school education. There were no differences between women who received calcium carbonate and those who did not (OR= 0.96; 95% CI= 0.73–1.27). The group of adolescents (13 to 18 yrs old) in the calcium plus conjugated linoleic acid was protected for preeclampsia (OR= 0.00; 95% CI= 0.00–0.44) independent of the confounder variables. Conclusions: 1. Calcium supplementation during pregnancy did not have preventive effects on preeclampsia. 2. Calcium plus Conjugated Linoleic acid provided to adolescents was observed to have preventive effect on Preeclampsia.

Preeclampsia prevention: a case-control study nested in the cohort

Introduction: Preeclampsia is the main complication of pregnancy in developing countries. Calcium starting at 14 weeks of pregnancy is indicated to prevent the disease. Recent advances in prevention of preeclampsia endorse the addition of conjugated linoleic acid. Objective: To estimate the protective effect from calcium alone, compared to calcium plus conjugated linoleic acid in nulliparous women at risk of preeclampsia. Methods: A case-control design nested in the cohort of nulliparous women attending antenatal care from 2010 to 2014. The clinical histories of 387 cases of preeclampsia were compared with 1,054 normotensive controls. The exposure was prescriptions for calcium alone, the first period, or calcium plus conjugated linoleic acid, the second period, from 12 to 16 weeks of gestational age to labor. Confounding variables were controlled, allowing only nulliparous women into the study and stratifying by age, education and ethnic group. Results: The average age was 26.4 yrs old (range= 13-45), 85% from mixed ethnic backgrounds and with high school education. There were no differences between women who received calcium carbonate and those who did not (OR= 0.96; 95% IC= 0.73–1.27). The group of adolescents (13 to 18 yrs old) in the calcium plus conjugated linoleic acid was protected for preeclampsia (OR= 0.00; 95% CI= 0.00–0.44) independent of the confounder variables. Conclusions: 1. Calcium supplementation during pregnancy did not have preventive effects on preeclampsia. 2. Calcium plus Conjugated Linoleic acid provided to adolescents was observed to have preventive effect on Preeclampsia.

Regards sur les territoires des ancrages haïtiano-montréalais : les impacts des pratiques transnationales au quotidien

À Montréal, les Haïtiens forment le troisième groupe ethnique en importance et offrent un exemple de peuple en diaspora. Étudier leurs mobilités et pratiques transnationales, ainsi que leurs incidences sur la redéfinition des concepts d’identité et de territoire, permet alors de comprendre les articulations entre le local et le transnational, dans le contexte de globalisation et de rétrécissement du monde permis par les nouvelles technologies. L’objectif de la recherche est de comprendre l’impact des pratiques transnationales et des médias dans la construction territoriale et l’ancrage des Haïtiens montréalais. Pour ce faire, 18 entrevues de type récit de vie ont été menées auprès d’un échantillon représentant les différentes vagues d’immigration haïtienne et des tables rondes ont été organisées. L’analyse des discours a permis de mettre en lumière les trajectoires, les lieux et types d’ancrages ainsi que le rôle des nouvelles technologies dans les liens translocaux de cette communauté. Les résultats, non généralisables, mettent de l’avant le rôle important des médias dans l’ancrage. Par exemple, l’ancrage des migrants de la première vague a été facilité par la création de radios haïtiennes, ces dernières ayant aidé à cimenter la communauté d’alors. Pour les deuxièmes générations, les nouveaux médias permettent de s’identifier à la diaspora et de s’ancrer en Haïti, avec des projets de développement, comme à Montréal, à travers l’expérience du cosmopolitisme. Finalement, l’analyse des récits de vie des nouveaux arrivants le confirme : les médias donnent la possibilité d’un ancrage inédit gardé à disposition avec les nouvelles technologies d’information et de communication.

The Relationship of Instructor Technical Literacy to the Academic Performance of Students in Career Academies

Career Academy instructors’ technical literacy is vital to the academic success of students. This nonexperimental ex post facto study examined the relationships between the level of technical literacy of instructors in career academies and student academic performance. It was also undertaken to explore the relationship between the pedagogical training of instructors and the academic performance of students. Out of a heterogeneous population of 564 teachers in six targeted schools, 136 teachers (26.0 %) responded to an online survey. The survey was designed to gather demographic and teaching experience data. Each demographic item was linked by researchers to teachers’ technology use in the classroom. Student achievement was measured by student learning gains as assessed by the reading section of the FCAT from the previous to the present school year. Linear and hierarchical regressions were conducted to examine the research questions. To clarify the possibility of teacher gender and teacher race/ethnic group differences by research variable, a series of one-way ANOVAs were conducted. As revealed by the ANOVA results, there were not statistically significant group differences in any of the research variables by teacher gender or teacher race/ethnicity. Greater student learning gains were associated with greater teacher technical expertise integrating computers and technology into the classroom, even after controlling for teacher attitude towards computers. Neither teacher attitude toward technology integration nor years of experience in integrating computers into the curriculum significantly predicted student learning gains in the regression models. Implications for HRD theory, research, and practice suggest that identifying teacher levels of technical literacy may help improve student academic performance by facilitating professional development strategies and new parameters for defining highly qualified instructors with 21st century skills. District professional development programs can benefit by increasing their offerings to include more computer and information communication technology courses. Teacher preparation programs can benefit by including technical literacy as part of their curriculum. State certification requirements could be expanded to include formal surveys to assess teacher use of technology.

Regards sur les territoires des ancrages haïtiano-montréalais : les impacts des pratiques transnationales au quotidien

À Montréal, les Haïtiens forment le troisième groupe ethnique en importance et offrent un exemple de peuple en diaspora. Étudier leurs mobilités et pratiques transnationales, ainsi que leurs incidences sur la redéfinition des concepts d’identité et de territoire, permet alors de comprendre les articulations entre le local et le transnational, dans le contexte de globalisation et de rétrécissement du monde permis par les nouvelles technologies. L’objectif de la recherche est de comprendre l’impact des pratiques transnationales et des médias dans la construction territoriale et l’ancrage des Haïtiens montréalais. Pour ce faire, 18 entrevues de type récit de vie ont été menées auprès d’un échantillon représentant les différentes vagues d’immigration haïtienne et des tables rondes ont été organisées. L’analyse des discours a permis de mettre en lumière les trajectoires, les lieux et types d’ancrages ainsi que le rôle des nouvelles technologies dans les liens translocaux de cette communauté. Les résultats, non généralisables, mettent de l’avant le rôle important des médias dans l’ancrage. Par exemple, l’ancrage des migrants de la première vague a été facilité par la création de radios haïtiennes, ces dernières ayant aidé à cimenter la communauté d’alors. Pour les deuxièmes générations, les nouveaux médias permettent de s’identifier à la diaspora et de s’ancrer en Haïti, avec des projets de développement, comme à Montréal, à travers l’expérience du cosmopolitisme. Finalement, l’analyse des récits de vie des nouveaux arrivants le confirme : les médias donnent la possibilité d’un ancrage inédit gardé à disposition avec les nouvelles technologies d’information et de communication.

Infección por virus sincitial respiratorio y su relación con valores de IGG en niños críticos

Antecedente: La infección por el virus sincitial respiratorio (VSR) representa una elevada morbimortalidad, y en algunos casos necesidad de manejo en unidades de cuidado intensivo pediátrico (UCIP). La respuesta inmunológica influye de manera directa en la expresión de la severidad y pronóstico de los pacientes con infección respiratoria. Metodología: Estudio de una cohorte retrospectiva de pacientes con infección respiratoria grave secundaria a VSR, sin historia de inmunodeficiencia, atendidos en la UCIP del Hospital Universitario Clínica San Rafael. Se realizó análisis descriptivoglobaly de acuerdo a la categorización de las prueba de IgG. Resultados: De 188 pacientes que ingresaron a la UCIP, 13% presentaron infección por VSR (24), con una edad promedio de 7,3 (DE=3,6) meses. Pertenecían al sexo masculino79,83%. Se encontró que 12,5% tenían un valor de IgGbajo para su edad, 58,33% tenían valores en límite inferior y el 29,17% dentro de rangos normales para su edad. En los pacientes con IgG baja, fue mayor la presentación de choque séptico que no responde a líquidos (100 vs 92 vs 86%), la mediana de días de ventilación mecánica fue mayor (8 vs 6 vs 5 respectivamente), así como la mortalidad (67 vs 7,1 vs 0%). Conclusión: Nuestra serie encontró que aquellos pacientes con niveles bajos o valores en el límite inferior de IgG sérica tuvieron mayor compromiso sistémico, mayor duración de ventilación mecánica y mayor mortalidad. Se necesitan estudios prospectivos que relaciones niveles bajos de IgG con severidad y pronostico en estos pacientes con infección grave por VSR.

Linguistic behavior of Italian descendants in Cascavel/PR

The maintenance and preservation of a linguistic variety are linked to historical issues, which consequently outline the beliefs and attitudes of a community. Depending on the community in which the speaker is inserted, his way of communicating can be stigmatized or prestigious. Thus, in addition to historical factors, the cognoscenti, affective and emotional components, which are connected to the way of thinking, feeling and evaluate are crucial for maintenance or not of a linguistic variety. Therefore consider the immigration process of Italian and migration of the descendants of this ethnic group until reach Cascavel city is important to understand how historical factors influence the beliefs and attitudes of the Italian community from southern region in this city. In addition, Frosi, Faggion Dal and Horn (2010) binding on the language attitudes also to social factors age and gender. Thus, in order to demonstrate the behavior of some descendants of Italians in Cascavel city before the language of their ancestors, 18 informants were selected, Italian descendants of southern colonization and that live in this town for more than 30 years or that were born in the city, which were distributed in the following dimensions: through generational and sexual. From this, individual interviews were conducted through the application of a semi-guided questionnaire and the data allowed checking the linguistic and cultural behavior of the Italian descent community from southern region, that is, those who came from Rio Grande do Sul and/or Santa Catarina states. We found that bilingualism levels vary depending on social factors such as gender and age, as well as historical factors. Language is a form of expression of a culture, however, an ethnic community does not presuppose the existence of a speech community.

Ethnic diversity as a multilevel construct:the combined effects of dissimilarity, group diversity, and societal status on learning performance in work groups

The authors present a model of the multilevel effects of diversity on individual learning performance in work groups. For ethnically diverse work groups, the model predicts that group diversity elicits either positive or negative effects on individual learning performance, depending on whether a focal individual’s ethnic dissimilarity from other group members is high or low. By further considering the societal status of an individual’s ethnic origin within society (Anglo versus non-Anglo for our U.K. context), the authors hypothesize that the model’s predictions hold more strongly for non-Anglo group members than for Anglo group members. We test this model with data from 412 individuals working on a 24-week business simulation in 87 four- to seven-person groups with varying degrees of ethnic diversity. Two of the three hypotheses derived from the model received full support and one hypothesis received partial support. Implications for theory development, methods, and practice in applied group diversity research are discussed.

Using self-referencing to explain the effectiveness of ethnic minority models in advertising

Advertising research has generally not gone beyond offering support for a positive effect where ethnic models in advertising are viewed by consumers of the same ethnicity. This study offers an explanation behind this phenomenon that can be useful to marketers using self-reference theory. Our experiment reveals a strong self-referencing effect for ethnic minority individuals. Specifically, Asian subjects (the ethnic minority group) self-referenced ads with Asian models more than white subjects (the ethnic majority group). However, this result was not evident for white subjects. Implications for academics and advertisers are discussed.