819 resultados para Early intervention
Resumo:
Abnormal development can lead to deficits in adult brain function, a trajectory likely underlying adolescent-onset psychiatric conditions such as schizophrenia. Developmental manipulations yielding adult deficits in rodents provide an opportunity to explore mechanisms involved in a delayed emergence of anomalies driven by developmental alterations. Here we assessed whether oxidative stress during presymptomatic stages causes adult anomalies in rats with a neonatal ventral hippocampal lesion, a developmental rodent model useful for schizophrenia research. Juvenile and adolescent treatment with the antioxidant N-acetyl cysteine prevented the reduction of prefrontal parvalbumin interneuron activity observed in this model, as well as electrophysiological and behavioral deficits relevant to schizophrenia. Adolescent treatment with the glutathione peroxidase mimic ebselen also reversed behavioral deficits in this animal model. These findings suggest that presymptomatic oxidative stress yields abnormal adult brain function in a developmentally compromised brain, and highlight redox modulation as a potential target for early intervention.
Resumo:
Highlights: * Misclassification of workers as “independent contractors” rather than “employees,” is a growing problem in Iowa and across the nation....pg. 2 * The Reemployment Services program is designed to be an early intervention by offering intensive services to job seekers receiving unemployment insurance.....pg. 2
Resumo:
Acquired pressure ulcer is associated with significant human, economic and functional consequences. Its prevalence varies between 3 and 23% in a community hospital and between 7 and 54% in an elderly home residency. Pressure ulcer healing is a complex process which involves numerous cellular and molecular mechanisms. An altered nutritional status is a contributing factor in the development of pressure ulcers and the delay in pressure ulcer healing. The key to management of undernutrition is screening and early intervention. According to the gravity of undernutrition, various degrees of intervention will be required. Systematic oral supplementation with various nutrients may provide benefit in the prevention of pressure ulcers, but further studies have to be completed in human subjects prior to being recommended for the treatment of pressure ulcers.
Resumo:
[eng] There is a vast literature on intergenerational mobility in sociology and economics. Similar interest has emerged for the phenomenon of over-education in both disciplines. There are no studies, however, linking these two research lines. We study the relationship between social mobility and over-education in a context of educational expansion. Our framework allows for the evaluation of several policies, including those affecting social segregation, early intervention programs and the power of unions. Results show the evolution of social mobility, over-education, income inequality and equality of opportunity under each scenario.
Resumo:
PURPOSE OF REVIEW: We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI. RECENT FINDINGS: Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or disease-related cognitive decline. Amyloid burden, white matter hyperintensities and local patterns of brain atrophy seem to have differential impact on cognition, particularly on episodic and working memory - the most vulnerable domains in 'normal aging' and Alzheimer's disease. Studies suggesting that imaging biomarkers of neurodegeneration are independent of amyloid-β give rise to new hypothesis regarding the pathological cascade in Alzheimer's disease. Findings in patients with autosomal-dominant Alzheimer's disease confirm the notion of differential temporal trajectory of amyloid deposition and brain atrophy to add another layer of complexity on the basic mechanisms of cognitive aging and neurodegeneration. Finally, the concept of cognitive reserve in 'supernormal aging' is questioned by evidence for the preservation of neurochemical, structural and functional brain integrity in old age rather than recruitment of 'reserves' for maintaining cognitive abilities. SUMMARY: Recent advances in clinical neuroscience, brain imaging and genetics challenge pathophysiological hypothesis of neurodegeneration and cognitive aging dominating the field in the last decade and call for reconsidering the choice of therapeutic window for early intervention.
Resumo:
Many would argue that the dramatic rise in autism has reached critical mass, and this council echoes that statement. Iowa, like many states in the nation, is currently ill equipped to handle the large influx of children and adults with autism. When this council was initially formed we were facing diagnosis rates of 1 in 150 and currently the diagnosis rate is 1 in 91. Current resource strains in education, qualified trained professionals, access to care, and financial services are rapidly deteriorating Iowa’s ability to deliver quality services to children, adults, and families affected by autism. If Iowa leadership fails to act quickly the already strained system will face a breaking point in the following areas: financing, coordination of care, educational resources, early identification, adult services, and access to service delivery - just to name a few. This council has taken the past 12 plus months hearing testimony from state officials, providers, and caregivers to ensure that care for those with autism is effective, cost efficient, and accessible. This council will be making recommendations on three major areas; early identification, seamless support/coordination of care, and financing of care. While these areas will be highlighted in this first annual report it in no way minimizes other areas that need to be addressed such as early intervention, special education, training, in-home support services, financing options, and data collection. Implementing the initial recommendations of this council will lay foundational support for the areas mentioned above. Often those in position to help ask what can be done to help families in Iowa. This council has provided a roadmap to help facilitate effective and proven treatments to children and adults with autism.
Resumo:
[eng] There is a vast literature on intergenerational mobility in sociology and economics. Similar interest has emerged for the phenomenon of over-education in both disciplines. There are no studies, however, linking these two research lines. We study the relationship between social mobility and over-education in a context of educational expansion. Our framework allows for the evaluation of several policies, including those affecting social segregation, early intervention programs and the power of unions. Results show the evolution of social mobility, over-education, income inequality and equality of opportunity under each scenario.
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
Resumo:
The purpose of the newsletter is to communicate with parents and professionals about newborn hearing screening and follow up in Iowa. We will share information about: Hearing screenings Early intervention, including communication opportunities Resources available for parents and professionals “Best practices” by hospitals, Area Education Agencies (AEAs), private practice audiology offi ces or other health and education providers working with children who are deaf or hard of hearing National research Iowa EHDI program goals EHDI program progress, system development, evaluation Family stories Highlights from the EHDI Advisory Committee
