Containing the diseases in aquaculture

A brief discussion is presented on epizootics and their containment in the aquaculture industry, in the form of a question-and-answer interview. Particular reference is made to activities carried out by the OIE (Office International des Epizooties), whose main activities include the provision of guidelines and standards for health protection applicable to international trade in live animals and their products. It has devised an early warning system to apprise its member countries of the occurence of disease outbreaks that would have serious repercussions on public health or the economics of animal products. URI

Parasitic fish diseases and their impact on potential fish production in East Africa

Protein deficient diets are a standard way of life in many parts of East Africa;this of course tends to result in shorter life expectancy and chronic ill-health. Population increase is sufficiently high to outdistance the economic gains that may be made in various fields. With recurrent shortages of basic commodities not only in East Africa, but in many parts of the world, it is becoming increasingly clear that agricultural production practices must be maximised rapidly in order to meet the world's constantly expanding need for food. Here in East Africa, while our food requirements can be met most of the time, our protein requirements are far from being met. Yields from traditional fishery resources, must therefore be increased. The farming of fish (aquaculture)adds a new dimension to food production in general and high quality protein production in particular, in that it can be incorporated into other agricultural production activities.

Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation

Insulin-like growth factor-binding protein (IGFBP)-3 is the major insulin-like growth factor (IGF) carrier protein in the bloodstream. IGFBP-3 prolongs the half-life of circulating IGFs and prevents their potential hypo-glycemic effect. IGFBP-3 is also expressed in many peripheral tissues in fetal and adult stages. In vitro, IGFBP-3 can inhibit or potentiate IGF actions and even possesses IGF-independent activities, suggesting that local IGFBP-3 may also have paracrine/autocrine function(s). The in vivo function of IGFBP-3, however, is unclear. In this study, we elucidate the developmental role of IGFBP-3 using the zebrafish model. IGFBP-3 mRNA expression is first detected in the migrating cranial neural crest cells and subsequently in pharyngeal arches in zebrafish embryos. IGFBP-3 mRNA is also persistently expressed in the developing inner ears. To determine the role of IGFBP-3 in these tissues, we ablated the IGFBP-3 gene product using morpholino-modified antisense oligonucleotides (MOs). The IGFBP-3 knocked down embryos had delayed pharyngeal skeleton morphogenesis and greatly reduced pharyngeal cartilage differentiation. Knockdown of IGFBP-3 also significantly decreased inner ear size and disrupted hair cell differentiation and semicircular canal formation. Furthermore, reintroduction of a MO-resistant form of IGFBP-3 "rescued" the MO-induced defects. These findings suggest that IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner car development and growth in zebrafish.