BRAIN ACTIVATION AND CONNECTIVITY IN NON-DISABLED MULTIPLE SCLEROSIS PATIENTS

Multiple sclerosis (MS) is the most common demyelinating disease affecting the central nervous system. There is no cure for MS and current therapies have limited efficacy. While the majority of individuals with MS develop significant clinical disability, a subset experiences a disease course with minimal impairment even in the presence of significant apparent tissue damage on magnetic resonance imaging (MRI). The current studies combined functional MRI and diffusion tensor imaging (DTI) to elucidate brain mechanisms associated with lack of clinical disability in patients with MS. Recent evidence has implicated cortical reorganization as a mechanism to limit the clinical manifestation of the disease. Functional MRI was used to test the hypothesis that non-disabled MS patients (Expanded Disability Status Scale ≤ 1.5) show increased recruitment of cognitive control regions (dorsolateral prefrontal and anterior cingulate cortex) while performing sensory, motor and cognitive tasks. Compared to matched healthy controls, patients increased activation of cognitive control brain regions when performing non-dominant hand movements and the 2-back working memory task. Using dynamic causal modeling, we tested whether increased cognitive control recruitment is associated with alterations in connectivity in the working memory functional network. Patients exhibited similar network connectivity to that of control subjects when performing working memory tasks. We subsequently investigated the integrity of major white matter tracts to assess structural connectivity and its relation to activation and functional integration of the cognitive control system. Patients showed substantial alterations in callosal, inferior and posterior white matter tracts and less pronounced involvement of the corticospinal tracts and superior longitudinal fasciculi (SLF). Decreased structural integrity within the right SLF in patients was associated with decreased performance, and decreased activation and connectivity of the cognitive control system when performing working memory tasks. These studies suggest that patient with MS without clinical disability increase cognitive control system recruitment across functional domains and rely on preserved functional and structural connectivity of brain regions associated with this network. Moreover, the current studies show the usefulness of combining brain activation data from functional MRI and structural connectivity data from DTI to improve our understanding of brain adaptation mechanisms to neurological disease.

Lung cancer screening with CT: evaluation of radiologists and different computer assisted detection software (CAD) as first and second readers for lung nodule detection at different dose levels

OBJECTIVES To find the best pairing of first and second reader at highest sensitivity for detecting lung nodules with CT at various dose levels. MATERIALS AND METHODS An anthropomorphic lung phantom and artificial lung nodules were used to simulate screening CT-examination at standard dose (100 mAs, 120 kVp) and 8 different low dose levels, using 120, 100 and 80 kVp combined with 100, 50 and 25 mAs. At each dose level 40 phantoms were randomly filled with 75 solid and 25 ground glass nodules (5-12 mm). Two radiologists and 3 different computer aided detection softwares (CAD) were paired to find the highest sensitivity. RESULTS Sensitivities at standard dose were 92%, 90%, 84%, 79% and 73% for reader 1, 2, CAD1, CAD2, CAD3, respectively. Combined sensitivity for human readers 1 and 2 improved to 97%, (p1=0.063, p2=0.016). Highest sensitivities--between 97% and 99.0%--were achieved by combining any radiologist with any CAD at any dose level. Combining any two CADs, sensitivities between 85% and 88% were significantly lower than for radiologists combined with CAD (p<0.03). CONCLUSIONS Combination of a human observer with any of the tested CAD systems provide optimal sensitivity for lung nodule detection even at reduced dose at 25 mAs/80 kVp.

Just Reading? How Gender-Fair Language Triggers Readers' Use of Gender-Fair Forms

Gender-fair language, that is, referring to men and women with symmetrical linguistic forms, has been found to promote gender equality, but it is largely unknown which factors help make gender-fair forms more common in everyday life. Two studies examined whether speakers of German used more gender-fair forms after reading a text with gender-fair wording (vs. masculine generics vs. no personal nouns vs. another topic). Both studies showed consistently that women used more gender-fair forms after reading the gender-fair text than the other texts, whereas men did not. Men employed more gender-fair forms only after being made aware of these forms (Study 2). To conclude, merely reading gender-fair texts enhances women’s inclination to use gender-fair language, whereas men need to be made aware of this type of language use. Both studies highlight the importance of using gender-fair language frequently and consistently in everyday life.

Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers.

Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data.

The Black-White Achievement Gap Amongst Struggling Readers: A Case Study of Early Intervention Outcomes in Massachusetts

A number of analyses of large data sets have suggested that the reading achievement gap between African American and White U.S. is negligible or small at school entry, but widens substantially during the school years because African American students show slower rates of growth in elementary and secondary school. Identifying when and why gaps occur, therefore, is a an important research endeavor. In addition, being able to predict which African American children are most likely to fall behind can contribute to efforts to close the achievement gap. This paper analyzes first grade and third grade data on African American and White children in Massachusetts who all were identified in first grade as struggling readers and enrolled in Reading Recovery—an individualized intervention. All the children were low-income and attending urban schools. Using Observation Survey data from first grade, and MCAS Reading data from 3rd grade, we found that the African American and White students made equal average progress while in first grade, but by the end of third grade showed a large gap in MCAS proficiency rates. We discuss the results in terms of school quality, reading development, dialect issues, testing formats, and the need to provide long-term support to vulnerable learners.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Readers : Más allá del argumento

Fil: Ruiz Arcodia, Libertad. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Readers : Más allá del argumento

Fil: Ruiz Arcodia, Libertad. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Imaginario social en la publicidad web de los e-readers

Se exploran las significaciones imaginarias que se materializan en los discursos publicitarios sobre los aparatos lectores de libros electrónicos comúnmente denominados "e-readers". Se parte de la hipótesis de que se cruzan significaciones imaginarias asociadas tanto al imaginario neotecnológico de las tecnologías digitales (Cabrera, 2006, 2011) como a lo que podríamos denominar el imaginario del "orden de los libros" (Chartier, 2000, 2005). Para realizar la exploración se analizan los discursos publicitarios de las páginas Web de tres casos: las marcas Kindle de Amazon, Kobo y Bq de Movistar. Se concluye que los e-readers son aparatos que participan del imaginario neotecnológico y vienen a integrar el complejo de las tecnologías digitales para la vida cotidiana, y que remiten también en gran medida a las significaciones imaginarias que dieron lugar a la hegemonía del papel en la cultura occidental por más de cinco siglos.

Interacción con juguetes para usuarios con discapacidad usando equipos con S.O. Android

El proyecto realizado, trata de una aplicación desarrollada en la plataforma Android, orientada a personas con algún tipo de discapacidad sensorial o psíquica. Dicha aplicación fomenta el uso y la integración de dispositivos móviles en este tipo de sector de población. Está pensada, para que, un usuario con discapacidad, pueda interactuar con ella y de forma transparente a él, se ha creado un sistema mediante el cual, se registra todo el comportamiento que ese usuario ha tenido durante el tiempo de uso de la aplicación, con el fin de llevar un seguimiento del mismo; evaluar si existen cambios en él; determinar si son necesarios algunos cambios en la aplicación que favorezcan una mejoría en cuanto al uso y consecución de resultados en el paciente, etc. Se ha combinado el uso de una aplicación instalada sobre un sistema operativo de libre distribución, concretamente Android, con un juguete de código abierto, como es Sphero. Eso ha permito el desarrollo de una aplicación perfectamente ajustada a los requisitos funcionales definidos, con una robustez y eficiencia similar a una aplicación de sistemas operativos móviles cerrados. Es importarte remarcar, que la primera finalidad de este proyecto es ofrecer la posibilidad de usar un juguete, como Sphero, que está orientado a un sector de población sin discapacidad, haciendo uso de cualquier dispositivo móvil, a personas con diferentes grados de discapacidad sensorial, motora y psíquica. Siempre clarificando, que no existe la posibilidad de usar esta aplicación para cualquier tipo y grado de discapacidad, ya que, ello supondría, un proyecto de una envergadura enorme. El hecho de usar un dispositivo móvil, es un derecho, que todos tenemos. Y por ello, se espera que tras la lectura y comprensión de este proyecto, se motive a los lectores a seguir desarrollando aplicaciones para que cualquier usuario, con discapacidad o no, tenga las mismas oportunidades de interactuación con dispositivos móviles. The carried out project, is an application developed on the Android platform , aimed at people with some kind of sensory or mental disability . This application encourages the use and integration of mobile devices in this type of population sector. It is designed to be interacted by a disable person and transparently to that user, it has been created a system by which all behavior, that user has had during the time of use of the application, is recorded, that’s to keep track of it ; assess whether there are changes in it, determine if changes are needed in the application that favor an improvement in the use and achieving patient outcomes , etc. . It has combined the use of an application installed on an open source operating system, namely Android, an open source toy , as is Sphero . That has made it possible to develop an application perfectly adjusted to the functional requirements defined with a robustness and efficiency similar to a mobile OS application closed. It is important to note, that the first aim of this project is to offer the possibility of using a toy, like Sphero , which is geared to a sector of the population without disabilities , using any mobile device , for people with different degrees of sensory impairment , motor and mental . Always clarifying that there is no possibility to use this application for any type and degree of disability, because the magnitude of the project would have been infinitely greater. The fact of using a mobile device, is a right we all have. And so, it is expected that upon reading and understanding of this project, motivate readers to continue developing applications for any user , disabled or not, have the same opportunities for interaction with mobile devices .

Cortical auditory signal processing in poor readers

Magnetoencephalographic responses recorded from auditory cortex evoked by brief and rapidly successive stimuli differed between adults with poor vs. good reading abilities in four important ways. First, the response amplitude evoked by short-duration acoustic stimuli was stronger in the post-stimulus time range of 150–200 ms in poor readers than in normal readers. Second, response amplitude to rapidly successive and brief stimuli that were identical or that differed significantly in frequency were substantially weaker in poor readers compared with controls, for interstimulus intervals of 100 or 200 ms, but not for an interstimulus interval of 500 ms. Third, this neurological deficit closely paralleled subjects’ ability to distinguish between and to reconstruct the order of presentation of those stimulus sequences. Fourth, the average distributed response coherence evoked by rapidly successive stimuli was significantly weaker in the β- and γ-band frequency ranges (20–60 Hz) in poor readers, compared with controls. These results provide direct electrophysiological evidence supporting the hypothesis that reading disabilities are correlated with the abnormal neural representation of brief and rapidly successive sensory inputs, manifested in this study at the entry level of the cortical auditory/aural speech representational system(s).