The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Development of the insulin secretion mechanism in fetal and neonatal rat pancreatic B-cells: response to glucose, K+, theophylline, and carbamylcholine

We studied the development of the insulin secretion mechanism in the pancreas of fetal (19- and 21-day-old), neonatal (3-day-old), and adult (90-day-old) rats in response to stimulation with 8.3 or 16.7 mM glucose, 30 mM K+, 5 mM theophylline (Theo) and 200 µM carbamylcholine (Cch). No effect of glucose or high K+ was observed on the pancreas from 19-day-old fetuses, whereas Theo and Cch significantly increased insulin secretion at this age (82 and 127% above basal levels, respectively). High K+ also failed to alter the insulin secretion in the pancreas from 21-day-old fetuses, whereas 8.3 mM and 16.7 mM glucose significantly stimulated insulin release by 41 and 54% above basal levels, respectively. Similar results were obtained with Theo and Cch. A more marked effect of glucose on insulin secretion was observed in the pancreas of 3-day-old rats, reaching 84 and 179% above basal levels with 8.3 mM and 16.7 mM glucose, respectively. At this age, both Theo and Cch increased insulin secretion to close to two-times basal levels. In islets from adult rats, 8.3 mM and 16.7 mM glucose, Theo, and Cch increased the insulin release by 104, 193, 318 and 396% above basal levels, respectively. These data indicate that pancreatic B-cells from 19-day-old fetuses were already sensitive to stimuli that use either cAMP or IP3 and DAG as second messengers, but insensitive to stimuli such as glucose and high K+ that induce membrane depolarization. The greater effect of glucose on insulin secretion during the neonatal period indicates that this period is crucial for the maturation of the glucose-sensing mechanism in B-cells.

Combined use of modeling techniques for the development of the conceptual model in simulation projects

The objective of this paper is to utilize the SIPOC, flowchart and IDEF0 modeling techniques combined to elaborate the conceptual model of a simulation project. It is intended to identify the contribution of these techniques in the elaboration of the computational model. To illustrate such application, a practical case of a high-end technology enterprise is presented. The paper concludes that the proposed approach eases the elaboration of the computational model. © 2008 IEEE.

Expenditures, investment and financing for sustainable development in Trinidad and Tobago

Includes bibliography

Informe del Taller de Trabajo La dimensión ambiental en el Proyecto de Desarrollo Rural Integrado de la Región Sur de Honduras (DRI-SUR)" = Report of the Workshop on "The environmental dimension in Integrated Rural Development Projects in the Southern Region of Honduras (DRI-SUR)""

Presenta las conclusiones y recomendaciones del Taller que tuvo por objetivo analizar la incorporacion de la dimension ambiental en la planificacion del desarrollo, la dimension ambiental en el Proyecto DRI-SUR, y las politicas ambientales de los organismos internacionales de financiamiento para el desarrollo.

Propuestas de proyectos de cooperación horizontal para el desarrollo del sector minero-metalúrgico de América Latina: listado preliminar = Proposals for horizontal co-operation projects for the development of the mining and metallurgical sector of Latin America: preliminary list

Presenta proyectos de cooperacion horizontal para el desarrollo del sector minero-metalurgico propuestos por Argentina, Bolivia, Colombia, Ecuador, Guatemala, Panama, Paraguay, Peru y Republica Dominicana, los cuales han sido clasificados en proyectos de caracter regional o subregional y en proyectos de caracter multinacional.

Issues in the development of a regional mechanism

Includes bibliography

La dimensión ambiental en proyectos de desarrollo agrícola = The environmental dimension in agricultural development projects

Incluye Bibliografía

Population information and development in Latin America: suggested projects to be carried out by or in collaboration with the Latin American Population Information Area (INFOPAL) of CELADE

Previa una breve descripcion de los objetivos y actividades de INFOPAL, se formula un conjunto de proposiciones de proyectos a desarrollar en el futuro, con apoyo externo a Naciones Unidas, a traves de cada una de las unidades que integran el Programa, a saber: DOCPAL, unidad de procesamiento de la informacion en poblacion, y el Banco de Datos.

Ministry of Economic Development of Belize, Project Bank: manual for the appraisal and monitoring of projects

Contiene información sobre el sistema de información sobre proyectos del Ministerio de Desarrollo Económico de Belice, e instrucciones para la evaluación y monitoreo de proyectos

Gestión ambiental y los grandes proyectos de aprovechamiento de recursos hídricos = Environmental management and large water resource development projects

Incluye Bibliografía

Manual on economic development projects

In this study, projects are not regarded as isolated economic units; they are considered within the context of the entire economic system of which they will form a part. Thus the Manual presents both macroeconomic and microeconomic concepts. From this it must not be inferred that the Manual attempts to offer a combined microeconomic and macroeconomic theory. It seeks to contribute more to an appreciation of the problem than to its solution, thus widening the outlook of those who prepare projects so that they may make the greatest possible compilation of useful data for their economic appraisal.