Shipping interest. Speech of the Right Hon. W. Huskisson in the House of Commons, Monday, the 7th of May, 1827, on General Gascoyne's motion. "that a Select committee be appointed, to inquire into the present distressed state of the British commercial shipping interest."

Mode of access: Internet.

Shipping interest; Mr. Huskisson's speech, from the Glasgow courier of May 31st, &c. 1827.

An answer to Huskisson's speech.

Schwatkas search; sledging in the Arctic in quest of the Franklin records,

Mode of access: Internet.

Illustrative cases on criminal law,

"The cases are in a large part reprinted from an earlier collection of cases compiled by the present editor."--Pref.

Handbook of the law of contracts /

Includes bibliographical references and index.

Handbook of the law of contracts,

Mode of access: Internet.

Transactions of the Wordsworth Society.

"List of members," April 1883 (8 p.) is prefixed to no. 1; "List of members ... who have joined since April 1883" (1 l.) and "Constitution" (3 p.) are appended to no. 5 (with list of "Papers ... either read to the society, or published in its Transactions")

The boy's own book. A complete encyclopedia of all the diversions, athletic, scientific, and recreative of boyhood and youth ...

Contains added engr. t.-p.

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

The Raf-1 protein kinase is a major activator of the ERK MAPK pathway, which links signaling by a variety of cell surface receptors to the regulation of cell proliferation, survival, differentiation and migration. Signaling by Raf-1 is regulated by a complex and poorly understood interplay between phosphorylation events and protein-protein interactions. One important mode of Raf-1 regulation involves the phosphorylation-dependent binding of 14-3-3 proteins. Here, we have examined the mechanism whereby the C-terminal 14-3-3 binding site of Raf-1, S621, controls the activation of MEK-ERK signaling. We show that phosphorylation of S621 turns over rapidly and is enriched in the activated pool of endogenous Raf-1. The phosphorylation on this site can be mediated by Raf-1 itself but also by other kinase(s). Mutations that prevent the binding of 14-3-3 proteins to S621 render Raf-1 inactive by specifically disrupting its capacity to bind to ATP, and not by gross conformational alteration as indicated by intact MEK binding. Phosphorylation of S621 correlates with the inhibition of Raf-1 catalytic activity in vitro, but 14-3-3 proteins can completely reverse this inhibition. Our findings suggest that 14-3-3 proteins function as critical cofactors in Raf-1 activation, which induce and maintain the protein in a state that is competent for both ATP binding and MEK phosphorylation.

The boy's own book : a complete encyclopaedia of all the diversions, athletic, scientific, and recreative, of boyhood and youth.

Includes index.

Lt. Col. John Clark Papers, 1838-1851 [photocopy]

Lt. Col. John Clark (1787-1862) was born in Kingston, Upper Canada. In 1801 Clark became a private in the 1st regiment of the Lincoln Militia, serving under Ralfe Clench. By June 1812 he was promoted to lieutenant by Maj. Gen. Sir Isaac Brock. During the War of 1812 he served as lieutenant and adjutant for the Lincoln Militia flank company on the Niagara frontier under Col. William Claus, and was present at the surrender of the enemy at the battle of Queenston Heights. By 1838 the Lincoln Militia was being re-organized and Lt. Col John Clark was requested to lead the 5th Regiment, made up of men from both Grantham and Louth townships in Lincoln County. He served in this capacity until his retirement in 1851?. Around this same time Clark bought from William May Jr. a house in Grantham Township. He was to call his home Walnut Dale Farm. John Clark also served as the customs collector for Port Dalhousie, and as a secretary in the Welland Canal Company. One hundred years later efforts by a local heritage group to save John Clark’s home failed, when the house was hit by arsonists. By this time the house had become known as the May-Clark-Seiler House. See RG 195 Anne Taylor Fonds for more information regarding the efforts of the heritage group to save this home. Clark died in 1862 at the age of 79 years and is buried in Victoria Lawn Cemetery. John Clark’s daughter Catherine (mentioned in the diary portion of the papers) was married to William Morgan Eccles.

Letter to William Dickson from Thomas Clark

Letter to William Dickson from Thomas Clark regarding Mr. Goring’s claims and Clark Street’s affair with Brackbill (1 ¼ pages, handwritten), June 15, 1821.

Letter to the Honourable William Dickson from Thomas Clark

Letter to the Honourable William Dickson from Thomas Clark. Mr. Clark says that he would have been off a week ago if not for the Robert Hamilton arbitration. There is a hole in this letter and a slight bit of the text is affected (3 ½ pages, handwritten), April 14, 1829.

Indenture between William Dickson and Thomas Clark

Indenture between William Dickson and Thomas Clark (as per the Last Will and Testament of Robert Hamilton) of Niagara to Joseph Gatehill of Grimsby for the Lot lettered G in the Town of Grimsby. The document is torn and slightly stained. This does not affect the text, Aug. 19, 1819.