Practica Baldi 1525 : perutilis ac vere aurea practica iuris vtriusq[ue] monarche ac luminis d[omi]ni Baldi de Vbaldis de perusio no[n] solum aduocatis, veru[m] procuratoribus, [et] alijs practica[n]tibus summe necessaria, cu[m] additionibus domini Anton

Pie de imprenta tomado del colofón

Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders

Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. Here, we measured a significant decrease in the concentration of apoD in serum samples from schizophrenic patients. In contrast, apoD levels were significantly increased (92–287%) in dorsolateral prefrontal cortex (Brodmann's area 9) of schizophrenic and bipolar subjects. Elevated levels of apoD expression were also observed in the caudate of schizophrenic and bipolar subjects (68–89%). No differences in apoD immunoreactivity were detected in occipital cortex (Brodmann's area 18) in either group, or in the hippocampus, substantia nigra, or cerebellum of the schizophrenic group. The low serum concentrations of apoD observed in these patients supports recent hypotheses involving systemic insufficiencies in lipid metabolism/signaling in schizophrenia. Elevation of apoD expression selectively within central nervous system regions implicated in the pathology of these neuropsychiatric disorders suggests a focal compensatory response that neuroleptic drug regimens may augment.

Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction

The active form of vitamin D, 1α,25-dihydroxyvitamin D [1α,25(OH)2D], is synthesized from its precursor 25 hydroxyvitamin D [25(OH)D] via the catalytic action of the 25(OH)D-1α-hydroxylase [1α(OH)ase] enzyme. Many roles in cell growth and differentiation have been attributed to 1,25(OH)2D, including a central role in calcium homeostasis and skeletal metabolism. To investigate the in vivo functions of 1,25(OH)2D and the molecular basis of its actions, we developed a mouse model deficient in 1α(OH)ase by targeted ablation of the hormone-binding and heme-binding domains of the 1α(OH)ase gene. After weaning, mice developed hypocalcemia, secondary hyperparathyroidism, retarded growth, and the skeletal abnormalities characteristic of rickets. These abnormalities are similar to those described in humans with the genetic disorder vitamin D dependent rickets type I [VDDR-I; also known as pseudovitamin D-deficiency rickets (PDDR)]. Altered non-collagenous matrix protein expression and reduced numbers of osteoclasts were also observed in bone. Female mutant mice were infertile and exhibited uterine hypoplasia and absent corpora lutea. Furthermore, histologically enlarged lymph nodes in the vicinity of the thyroid gland and a reduction in CD4- and CD8-positive peripheral T lymphocytes were observed. Alopecia, reported in vitamin D receptor (VDR)-deficient mice and in humans with VDDR-II, was not seen. The findings establish a critical role for the 1α(OH)ase enzyme in mineral and skeletal homeostasis as well as in female reproduction and also point to an important role in regulating immune function.

D. Athanasii episcopi Alexandrini facundissimi illius ecclesiae propugnatoris omnia opera, quae in hunc vsq[ue] diem è Graeco in Latinam linguam versa sunt : nunc recens quamexactissima diligentia recognita & excusa, quorum catalogum sequens pagella indicabit /

Mode of access: Internet.

La Primavera del Botticelli : le Cantorie di Luca della Robbia e di Donatello : la Sepoltura di Lemmo Balducci : Opere d'arte dell'Arcispedale di Santa Maria Nuova /

On spine: Scritti d'arte.

Cousin Geoffrey, the old bachelor. A novel. To which is added Claude Stocq.

"Claude Stocq: a tale of the sixteenth century. From the French" (v. 3, p. [135]-323) not by the same author. cf. Advertisement, v. 1.

Les Della Robbia : leur vie et leur œuvre, d'après des documents inédits, suivi d'un catalogue de l'œuvre des Della Robbia en Italie et dans les principaux musée de l'Europe /

Mode of access: Internet.

Annali d'Italia, dal principio dell'era volgare sino all' anno 1500 /

Includes indexes.

Memoires de Messire Philippe de Comines, seigneur d'Argenton, où l'on trouve l'histoire des rois de France Louis XI. & Charles VIII

Initials, head- and tail-pieces.

Chronicon Adæ de Usk : A. D. 1377-1404 /

"Corrigenda": p. [244].

Vitamin D action and regulation of bone remodeling: Suppression of osteoclastogenesis by the mature osteoblast

Vitamin D acts through the immature osteoblast to stimulate osteoclastogenesis. Transgenic elevation of VDR in mature osteoblasts was found to inhibit osteoclastogenesis associated with an altered OPG response. This inhibition was confined to cancellous bone. This study indicates that vitamin D-mediated osteoclastogenesis is regulated locally by OPG production in the mature osteoblast.

Princesses et duchesses bibliophiles à la cour de René d'Anjou

De nombreuses dames de la cour d'Anjou ont exercé un mécénat littéraire et bibliophilique important à la cour d'Anjou. Parmi elles se trouvent Marie de Blois (v. 1340-1404), Yolande d'Aragon (1381-1442), Isabelle de Lorraine (v. 1400-1453), Jeanne de Laval (1433-1498) et Marie de Clèves (1426-1487). Le mécénat de ces femmes, parentes, épouses ou amies de René d'Anjou, est ici abordé à travers les documents d'archives et les manuscrits conservés qui attestent d'un intérêtréel et constant pour l'art du livre et de l'enluminure et pour la littérature en vogue à la cour. Une attention toute particulière est réservée au Pèlerinage de Vie humaine de Guillaume de Digulleville dont la version rimée, et plus tard la version en prose commandée par Jeanne de Laval, n'a cessé de captiver le lectorat féminin et notamment Marguerite d'Anjou, Blanche d'Anjou et Guyonne de Beauvau