Aparato para la corrección y adición de la obra que publicó en 1769 ... D. Joseph Berní y Catalá ... con el título Creacion, antiguedad y privilegios de los títulos de Castilla ...

Sign. : *-5*, A-Z2, 2A-2X2, 2Y-2Z4, 3A-3Q3, 3R2

Breue relacion de las ceremonias, y aparato de la basilica de S. Pedro, en la Canonizacion de Santo Tomas de Villanueva : de la Orden de San Agustin ...

Tít. tomado de principio de texto

Coeficientes de presión intersticial en el aparato de corte simple = Pore pressure coefficients for simple shear test

La actuación de cargas sobre un suelo saturado, produce, en función de la naturaleza de la solicitación, del tipo de suelo y de las condiciones de drenaje del terreno, un incremento de la presión sobre el agua de los intersticios. Se ha abordado el estudio de la generación de dicha presión intersticial a partir de muestras de suelo blando, normalmente consolidadas, procedentes del subsuelo del Puerto de Barcelona. Para ello se han utilizado los datos de una completa campaña experimental utilizando la máquina de ensayo de corte simple, y tras la adecuada interpretación del ensayo, se identifican los aspectos que se consideran clave para el proceso de generación de presión intersticial en el suelo, según las diferentes situaciones de carga actuante. Como conclusión, se plantea la generalización de la clásica ecuación que Skempton formuló hace casi 60 años y que permite interpretar la generación de presión intersticial para el aparato de ensayo triaxial. ncrease in pore pressure depending on the nature of the excitation, the type of soil and the drainage conditions of the ground are generated by loads acting on a saturated soil. It has approached the study of the generation of the pore pressure from usually consolidated soft soil samples from the basement of the Port of Barcelona. Data from an adequate experimental campaign using simple shear machine have been used, and the aspects that are considered key to the process of generation of pore pressure in the soil under different loading conditions acting have been identified. In conclusion, the generalization of Skempton's classical equation (formulated almost 60 years ago) and the interpretation of the pore pressure generation for triaxial test apparatus have been proposed.

Festiua pompa, y lucido aparato del mas solemne festejo : alegres canticos, sonoras harmonias ... de ... bodas... en, y espiritual desposorio de Sor Antonia Maria Real, y Cathanea con ... Christo, en el ... Convento de Santa Catharina de Sena de ... Valencia

Fecha de 1754 tomada de tít

Coeficientes de presión intersticial para suelos blandos en el aparato de corte simple

La actuación de cargas sobre un suelo saturado, produce, en función de la naturaleza de la solicitación, del tipo de suelo y de las condiciones de drenaje del terreno, un incremento de la presión sobre el agua de los intersticios. Se ha abordado el estudio de la generación de dicha presión intersticial a partir de muestras de suelo blando, normalmente consolidadas, procedentes del subsuelo del Puerto de Barcelona; para ello, se ha realizado una campaña experimental utilizando la máquina de ensayo de corte simple, y tras la adecuada interpretación del ensayo, se identifican los aspectos que se consideran clave para el proceso de generación de presión intersticial en el suelo, según las diferentes situaciones de carga actuante. Como conclusión, se plantea la generalización de la clásica ecuación que Skempton formuló hace casi 60 años para el aparato de ensayo triaxial.

Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors

From pharmacological studies using histamine antagonists and agonists, it has been demonstrated that histamine modulates many physiological functions of the hypothalamus, such as arousal state, locomotor activity, feeding, and drinking. Three kinds of receptors (H1, H2, and H3) mediate these actions. To define the contribution of the histamine H1 receptors (H1R) to behavior, mutant mice lacking the H1R were generated by homologous recombination. In brains of homozygous mutant mice, no specific binding of [3H]pyrilamine was seen. [3H]Doxepin has two saturable binding sites with higher and lower affinities in brains of wild-type mice, but H1R-deficient mice showed only the weak labeling of [3H]doxepin that corresponds to lower-affinity binding sites. Mutant mice develop normally, but absence of H1R significantly increased the ratio of ambulation during the light period to the total ambulation for 24 hr in an accustomed environment. In addition, mutant mice significantly reduced exploratory behavior of ambulation and rearings in a new environment. These results indicate that through H1R, histamine is involved in circadian rhythm of locomotor activity and exploratory behavior as a neurotransmitter.

Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

Various transcription factors act as nuclear effectors of the cAMP-dependent signaling pathway. These are the products of three genes in the mouse, CREB, CRE modulator (CREM), and ATF-1. CREM proteins are thought to play important roles within the hypothalamic–pituitary axis and in the control of rhythmic functions in the pineal gland. We have generated CREM-mutant mice and investigated their response in a variety of behavioral tests. CREM-null mice show a drastic increase in locomotion. In contrast to normal mice, the CREM-deficient mice show equal locomotor activity during the circadian cycle. The anatomy of the hypothalamic suprachiasmatic nuclei, the center of the endogenous pacemaker, is normal in mutant mice. Remarkably, CREM mutant mice also elicit a different emotional state, revealed by a lower anxiety in two different behavioral models, but they preserve the conditioned reactiveness to stress. These results demonstrate the high degree of functional specificity of each cAMP-responsive transcription factor in behavioral control.

Tarsier-like locomotor specializations in the Oligocene primate Afrotarsius

Tarsiers and extinct tarsier-like primates have played a central role in views of primate phylogeny and evolution for more than a century. Because of the importance of tarsiers in so many primatological problems, there has been particular interest in questions about the origin of tarsier specializations and the biogeography of early tarsioid radiations. We report on a new fossil of rare Afrotarsius that shows near identity to modern Tarsius in unique specializations of the leg, which provides information about the locomotor behavior and clarifies the phylogenetic position of this previously controversial primate. These specializations constitute evidence that Afrotarsius is a tarsiid, closely related to extant Tarsius; hence, it is now excluded from being a generalized sister taxon to Anthropoidea.

Molecular phylogenetic analysis of evolutionary trends in stonefly wing structure and locomotor behavior

Insects in the order Plecoptera (stoneflies) use a form of two-dimensional aerodynamic locomotion called surface skimming to move across water surfaces. Because their weight is supported by water, skimmers can achieve effective aerodynamic locomotion even with small wings and weak flight muscles. These mechanical features stimulated the hypothesis that surface skimming may have been an intermediate stage in the evolution of insect flight, which has perhaps been retained in certain modern stoneflies. Here we present a phylogeny of Plecoptera based on nucleotide sequence data from the small subunit rRNA (18S) gene. By mapping locomotor behavior and wing structural data onto the phylogeny, we distinguish between the competing hypotheses that skimming is a retained ancestral trait or, alternatively, a relatively recent loss of flight. Our results show that basal stoneflies are surface skimmers, and that various forms of surface skimming are distributed widely across the plecopteran phylogeny. Stonefly wings show evolutionary trends in the number of cross veins and the thickness of the cuticle of the longitudinal veins that are consistent with elaboration and diversification of flight-related traits. These data support the hypothesis that the first stoneflies were surface skimmers, and that wing structures important for aerial flight have become elaborated and more diverse during the radiation of modern stoneflies.

Characterization of a high-voltage-activated IA current with a role in spike timing and locomotor pattern generation

Transient A-type K+ channels (IA) in neurons have been implicated in the delay of the spike onset and the decrease in the firing frequency. Here we have characterized biophysically and pharmacologically an IA current in lamprey locomotor network neurons that is activated by suprathreshold depolarization and is specifically blocked by catechol at 100 μM. The biophysical properties of this current are similar to the mammalian Kv3.4 channel. The role of the IA current both in single neuron firing and in locomotor pattern generation was analyzed. The IA current facilitates Na+ channel recovery from inactivation and thus sustains repetitive firing. The role of the IA current in motor pattern generation was examined by applying catechol during fictive locomotion induced by N-methyl-d-aspartate. Blockade of this current increased the locomotor burst frequency and decreased the firing of motoneurons. Although an alternating motor pattern could still be generated, the cycle duration was less regular, with ventral roots bursts failing on some cycles. Our results thus provide insights into the contribution of a high-voltage-activated IA current to the regulation of firing properties and motor coordination in the lamprey spinal cord.