Call & response - Winter 2008

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume III, number 1 and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History and events calendar.

Call & response - Fall 2009

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume IV, number 3 and includes a message from the chair, list of board members, preservation project profile, African Americans during the Civil War, news from the South Carolina Department of Archives and History and events calendar.

Call & response - Spring/Summer 2009

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume IV, number 2 and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History, annual meeting information, and events calendar.

Call & response - Winter 2009

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume IV, number 1 and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History, and events calendar.

Call & response - Fall 2010

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume V, number 3 and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History, annual meeting information, and events calendar.

Call & response - Spring/Summer 2010

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume V, number 2 and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History and events calendar.

Call & response - Winter 2010

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume V, number 1 and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History, annual meeting information, and events calendar.

Call & response - 2011

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume VI and includes a message from the chair, list of board members, preservation project profile, news from the South Carolina Department of Archives and History and events calendar.

FZD6, MATN2 AND SLC25A32, POSSIBLE CANDIDATE GENES IN NONSYNDROMIC CLEFT LIP AND PALATE

Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common birth defect with a multifactorial etiology. Despite decades of research, the genetic underpinnings of NSCLP still remain largely unexplained. A genome wide association study (GWAS) of a large NSCLP African American family with seven affected individuals across three generations found evidence for linkage at 8q21.3-24.12 (LOD = 2.98). This region contained three biologically relevant candidate genes: Frizzled-6 (FZD6) (LOD = 2.8), Matrilin-2 (MATN2) (LOD = 2.3), and Solute Carrier Family 25, Member 32 (SLC26A32) (LOD = 1.6). Sequencing of the coding regions and the 5’ and 3’ UTRs of these genes in two affected family members identified a rare intronic variant, rs138557689 (c.-153+432A>C), in FZD6. The rs138557689/C allele segregated with the NSCLP phenotype; in silico analysis predicted and EMSA analysis showed that the 138557689/C allele creates new DNA binding sites. FZD6 is part of the WNT pathway, which is involved in craniofacial development, including midface development and upper lip fusion. Our novel findings suggest that an alteration in FZD6 gene regulation may perturb this tightly controlled biological pathway and in turn contribute to the development of NSCLP in this family. Studies are underway to further define how the rs138557689/C variant affects expression of FZD6.

Call & response - February 2016

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume X number 2 and includes a message from the chair, list of board members, spotlight on Vitoria A. Smalls and the agenda for the annual conference and awards ceremony.

Call & response -- Fall 2012

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume X number 2 and includes a message from the chair, list of board members, spotlight on Vitoria A. Smalls and the agenda for the annual conference and awards ceremony.

Call & response -- Spring 2012

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume X number 2 and includes a message from the chair, list of board members, spotlight on Vitoria A. Smalls and the agenda for the annual conference and awards ceremony.

Call & response -- Winter 2012

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume X number 2 and includes a message from the chair, list of board members, spotlight on Vitoria A. Smalls and the agenda for the annual conference and awards ceremony.

Call & response -- Fall 2013

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume X number 2 and includes a message from the chair, list of board members, spotlight on Vitoria A. Smalls and the agenda for the annual conference and awards ceremony.

Call & response -- Spring/Summer 2013

Call & Response is the newsletter of the South Carolina African American Heritage Commission, whose mission is to identify and promote the preservation of historic sites, structures, buildings, and culture of the African American experience in South Carolina. This is volume X number 2 and includes a message from the chair, list of board members, spotlight on Vitoria A. Smalls and the agenda for the annual conference and awards ceremony.