Quantitative contrast echocardiographic assessment of collateral derived myocardial perfusion during elective coronary angioplasty

OBJECTIVE To determine whether myocardial contrast echocardiography can be used to quantify collateral derived myocardial flow in humans. METHODS In 25 patients undergoing coronary angioplasty, a collateral flow index (CFI) was determined using intracoronary wedge pressure distal to the stenosis to be dilated, with simultaneous mean aortic pressure measurements. During balloon occlusion, echo contrast was injected into both main coronary arteries simultaneously. Echocardiography of the collateral receiving myocardial area was performed. The time course of myocardial contrast enhancement in images acquired at end diastole was quantified by measuring pixel intensities (256 grey units) within a region of interest. Perfusion variables, such as background subtracted peak pixel intensity and contrast transit rate, were obtained from a fitted gamma variate curve. RESULTS 16 patients had a left anterior descending coronary artery stenosis, four had a left circumflex coronary artery stenosis, and five had a right coronary artery stenosis. The mean (SD) CFI was 19 (12)% (range 0-47%). Mean contrast transit rate was 11 (8) seconds. In 17 patients, a significant collateral contrast effect was observed (defined as peak pixel intensity more than the mean + 2 SD of background). Peak pixel intensity was linearly related to CFI in patients with a significant contrast effect (p = 0.002, r = 0.69) as well as in all patients (p = 0.0003, r = 0.66). CONCLUSIONS Collateral derived perfusion of myocardial areas at risk can be demonstrated using intracoronary echo contrast injections. The peak echo contrast effect is directly related to the magnitude of collateral flow.

Clinical Performance of Screw- Versus Cement-Retained Fixed Implant-Supported Reconstructions- A Systematic Review.

PURPOSE To assess the survival outcomes and reported complications of screw- and cement-retained fixed reconstructions supported on dental implants. MATERIALS AND METHODS A Medline (PubMed), Embase, and Cochrane electronic database search from 2000 to September 2012 using MeSH and free-text terms was conducted. Selected inclusion and exclusion criteria guided the search. All studies were first reviewed by abstract and subsequently by full-text reading by two examiners independently. Data were extracted by two examiners and statistically analyzed using a random effects Poisson regression. RESULTS From 4,324 abstracts, 321 full-text articles were reviewed. Seventy-three articles were found to qualify for inclusion. Five-year survival rates of 96.03% (95% confidence interval [CI]: 93.85% to 97.43%) and 95.55% (95% CI: 92.96% to 97.19%) were calculated for cemented and screw-retained reconstructions, respectively (P = .69). Comparison of cement and screw retention showed no difference when grouped as single crowns (I-SC) (P = .10) or fixed partial dentures (I-FDP) (P = .49). The 5-year survival rate for screw-retained full-arch reconstructions was 96.71% (95% CI: 93.66% to 98.31). All-ceramic reconstruction material exhibited a significantly higher failure rate than porcelain-fused-to-metal (PFM) in cemented reconstructions (P = .01) but not when comparing screw-retained reconstructions (P = .66). Technical and biologic complications demonstrating a statistically significant difference included loss of retention (P ≤ .01), abutment loosening (P ≤ .01), porcelain fracture and/or chipping (P = .02), presence of fistula/suppuration (P ≤ .001), total technical events (P = .03), and total biologic events (P = .02). CONCLUSIONS Although no statistical difference was found between cement- and screw-retained reconstructions for survival or failure rates, screw-retained reconstructions exhibited fewer technical and biologic complications overall. There were no statistically significant differences between the failure rates of the different reconstruction types (I-SCs, I-FDPs, full-arch I-FDPs) or abutment materials (titanium, gold, ceramic). The failure rate of cemented reconstructions was not influenced by the choice of a specific cement, though cement type did influence loss of retention.

Tabellen enthaltend die Zeitangaben für den Beginn der Nacht und des Tages für die Breitengrade + 66 bis -38'' : zum Gebrauch f. d. jüd. Ritus

berechnet u. zsgest. von B. Cohn

Ms. hebr. oct. 66 - Bet ha-beḥirah

Vorbesitzer: Abraham Merzbacher

Ms. Barth. 66 - Homiliar (Sommerteil)

Vorbesitzer: St. Peter Urach; Bartholomaeusstift Frankfurt am Main;

In Börnes Aufsatz: "Juden in Frankfurt a. M." : (Börnes Schriften VI, S. 66 - 70)

L. G.

Evidence for Emergency Vaccination Having Played a Crucial Role to Control the 1965/66 Foot-and-Mouth Disease Outbreak in Switzerland.

Foot-and-mouth disease (FMD) is a highly contagious disease that caused several large outbreaks in Europe in the last century. The last important outbreak in Switzerland took place in 1965/66 and affected more than 900 premises and more than 50,000 animals were slaughtered. Large-scale emergency vaccination of the cattle and pig population has been applied to control the epidemic. In recent years, many studies have used infectious disease models to assess the impact of different disease control measures, including models developed for diseases exotic for the specific region of interest. Often, the absence of real outbreak data makes a validation of such models impossible. This study aimed to evaluate whether a spatial, stochastic simulation model (the Davis Animal Disease Simulation model) can predict the course of a Swiss FMD epidemic based on the available historic input data on population structure, contact rates, epidemiology of the virus, and quality of the vaccine. In addition, the potential outcome of the 1965/66 FMD epidemic without application of vaccination was investigated. Comparing the model outcomes to reality, only the largest 10% of the simulated outbreaks approximated the number of animals being culled. However, the simulation model highly overestimated the number of culled premises. While the outbreak duration could not be well reproduced by the model compared to the 1965/66 epidemic, it was able to accurately estimate the size of the area infected. Without application of vaccination, the model predicted a much higher mean number of culled animals than with vaccination, demonstrating that vaccination was likely crucial in disease control for the Swiss FMD outbreak in 1965/66. The study demonstrated the feasibility to analyze historical outbreak data with modern analytical tools. However, it also confirmed that predicted epidemics from a most carefully parameterized model cannot integrate all eventualities of a real epidemic. Therefore, decision makers need to be aware that infectious disease models are useful tools to support the decision-making process but their results are not equal valuable as real observations and should always be interpreted with caution.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 66 - Darstellung von J. Goullet (geb. Kraus) der schlechten Lebensumstände von Johanna Schopenhauer

u.a.: Hervorhebung der Freundschaft mit Johanna Schopenhauer; Ausflug nach Karlsbad; Vorlesung in Dresden; Bankrott des Bankhauses Muhl in Danzig; Mutter-Sohn-Beziehung; Adele Schopenhauer; Johann Wolfgang von Goethe;

Na 1 Nachlass Max Horkheimer, 66 - Korrespondenzen u.a. mit Ermin Cahn und Max Cahn (p. II 4, 256 - 433)

3 Briefe zwischen Charlotte Bühler und Max Horkheimer, 1946 sowie 4 Papers von Charlotte Bühler zum Antisemitismus; 55 Briefe zwischen Ermin Cahn, Max Cahn und Max Horkheimer, 1941-1949; 1 Brief und Beilage von Max Horkheimer an Max L. Cahn, 1948; 6 Briefe zwischen der Society for the Protection of Science and Learning und Max Horkheimer, 1944-1948; 16 Briefe zwischen Hadley Cantril und Max Horkheimer, 1948-1949 sowie 2 Manuskripte von Hadley Cantril : The Development od a Scientific Morality; Trends of Opinion During World War II; 12 Briefe und Beilage zwischen Charles Carlé und Max Horkheimer, 1942-1943;

Na 1 Nachlass Max Horkheimer, 260 - Korrespondenzen u.a. mit dem Direktor der Stadt- und Unibibliothek Frankfurt am Main Professor Clemens Köttelwesch (p. V 66, 138-320)

2 Briefe zwischen F. Champion Ward und Max Horkheimer, 1967; 1 Brief von Max Horkheimer an John Slawson, 1962; 21 Briefe zwischen dem Direktor der Stadt- und Unibibliothek Frankfurt am Main Professor Clemens Köttelwesch und Max Horkheimer, 1956-; 1 Brief an Hertha Dembitzer, 1974; 1 Brief von Hertha Dembitzer, 1974; Schenkungsbrief 1956; Hertha Dembitzer: 2 Briefe zwischen Hertha Dembitzer und Clemens Köttelwesch, 1974;

Ms. Praed. 66 - Scriptum super quartum Sententiarum

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 324 - Absichtserklärung an Professor Hugo von Meltzl über die bereitwillige Herstellung eines Artikels zur Schopenhauerschen Philosophie

u.a.: persönliche Beziehung zu Schopenhauer; Gustav Wilhelm Körber; Arthur Schopenhauer;

Fragm. lat. VII 90 - De bello Iudaico (L. VII c. 61 - 66)

Trägerband: Q 16/109; Vorbesitzer: Philippus Jacobus Otto

Zusätze und Verbesserungen zur "Monographie der rheinischen Pirolaceae" (Verhandlungen des Naturhistorischen Vereins, 66. Jahrg., 1909, S. 99-151)

Von H. Andres