North Carolina, 1808 (Image 2 of 3) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: To David Stone and Peter Brown, Esq. : this first actual survey of the state of North Carolina taken by the subscribers is respectfully dedicated by their humble servants, Jona. Price and John Strother ; engraved by W. H. Harrison. It was printed by C.P. Harrison in 1808. Scale [ca. 1:506,880]. This layer is image 2 of 3 total images of the three sheet source map, representing the central portion of the map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the North Carolina State Plane NAD 1983 coordinate system (in Feet) (Fipszone 3200). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, canals, cities and towns, selected public buildings (churches, inns), industry locations (e.g. mills, mines, etc.), selected private buildings with names of property owners, state and county boundaries, shoreline features, and more. Relief shown pictorially and by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Litigation relating to atomic testing : hearings before the Subcommittee on Administrative Law and Governmental Relations of the Committee on the Judiciary, House of Representatives, Ninety-ninth Congress, first session, on H.R. 1338 ... October 2 and 3, 1985.

Mode of access: Internet.

Organizational maintenance repair parts and special tools lists : crane-shovel, crawler mounted, 12-1/2 ton, 3/4 cu. yd, diesel engine driven, NSN 3810-00-869-3092, Bucyrus-Erie model 22BM.

Includes index.

Operator and organizational maintenance manual : crane-shovel, crawler mounted, 12 1/2-ton, 3/4-cu yd, diesel engine driven (Bucyrus-Erie) model 22BM), FSN 3810-869-3092.

Includes index.

Direct support and general support maintenance repair parts and special tools lists (including depot maintenance repair parts and special tools lists) : crane-shovel, crawler, mounted, 12-1/2 ton, 3/4 cu. yd, diesel engine driven (NSN 3810-00-869-3092) : Bucyrus-Erie model 22BM.

"December 1984."

Organizational maintenance repair parts and special tools lists : crane-shovel, crawler mounted, 12-1/2 ton, 3/4 cu. yd, diesel engine driven, NSN 3810-00-869-3092 : Bucyrus-Erie model 22BM.

Includes index.

Unit, direct support, and general support maintenance repair parts and special tools lists ... : crane-shovel, crawler mounted, 12-1/2-ton, 3/4 cu yd, diesel engine driven, NSN 3810-00-869-3092 : Bucyrus-Erie model 22BM.

"April 1992."

Organizational and direct support maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) for viewers, driver's night vision, AN/VVS-2(V)1 (NSN 5855-00-629-5278), AN/VVS-2(V)2 (NSN 5855-01-057-1880), AN/VVS-2(V)3 (NSN 5855-01-105-7793), AN/VVS-2(V)1A (NSN 5855-01-096-0871), and AN/VVS-2(V)2A (NSN 5855-01-096-0872).

Includes index.

Operator's manual : viewers, driver's, night vision, AN/VVS-2(V)1 (NSN 5855-00-629-5278), AN/VVS-2(V)1A (NSN 5855-01-096-0871), AN/VVS-2(V)2 (NSN 5855-01-057-1880), AN/VVS-2(V)2A (NSN 5855-01-096-0872), AN/VVS-2(V)3 (NSN 5855-01-105-7793).

"August 1982."

Expression of uncoupling proteins-1,-2 and-3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor

The abnormalities of lipid metabolism observed in cancer cachexia may be induced by a lipid-mobilizing factor produced by adenocarcinomas. The specific molecules and metabolic pathways that mediate the actions of lipid-mobilizing factor are not known. The mitochondrial uncoupling proteins-1, -2 and -3 are suggested to play essential roles in energy dissipation and disposal of excess lipid. Here, we studied the effects of lipid-mobilizing factor on the expression of uncoupling proteins-1, -2 and -3 in normal mice. Lipid-mobilizing factor isolated from the urine of cancer patients was injected intravenously into mice over a 52-h period, while vehicle was similarly given to controls. Lipid-mobilizing factor caused significant reductions in body weight (-10%, P=0.03) and fat mass (-20%, P<0.01) accompanied by a marked decrease in plasma leptin (-59%, P<0.01) and heavy lipid deposition in the liver. In brown adipose tissue, uncoupling protein-1 mRNA levels were elevated in lipid-mobilizing factor-treated mice (+96%, P<0.01), as were uncoupling proteins-2 and -3 (+57% and +37%, both P<0.05). Lipid-mobilizing factor increased uncoupling protein-2 mRNA in both skeletal muscle (+146%, P<0.05) and liver (+142%, P=0.03). The protein levels of uncoupling protein-1 in brown adipose tissue and uncoupling protein-2 in liver were also increased with lipid-mobilizing factor administration (+49% and +67%, both P=0.02). Upregulation by lipid-mobilizing factor of uncoupling proteins-1, -2 and -3 in brown adipose tissue, and of uncoupling protein-2 in skeletal muscle and liver, suggests that these uncoupling proteins may serve to utilize excess lipid mobilized during fat catabolism in cancer cachexia.

X-ray crystallographic and theoretical studies of an anticonvulsant enaminone:methyl 4-(4'-bromophenyl)amino-6-methyl-2-oxocyclohex-3-en-1-oate

Objective: The aims of this study were to establish the structure of the potent anticonvulsant enaminone methyl 4-(4′-bromophenyl)amino-6-methyl-2- oxocyclohex-3-en-1-oate (E139), and to determine the energetically preferred conformation of the molecule, which is responsible for the biological activity. Materials and Methods: The structure of the molecule was determined by X-ray crystallography. Theoretical ab initio calculations with different basis sets were used to compare the energies of the different enantiomers and to other structurally related compounds. Results: The X-ray crystal structure revealed two independent molecules of E139, both with absolute configuration C11(S), C12(R), and their inverse. Ab initio calculations with the 6-31G, 3-21G and STO-3G basis sets confirmed that the C11(S), C12(R) enantiomer with both substituents equatorial had the lowest energy. Compared to relevant crystal structures, the geometry of the theoretical structures shows a longer C-N and shorter C=O distance with more cyclohexene ring puckering in the isolated molecule. Conclusion: Based on a pharmacophoric model it is suggested that the enaminone system HN-C=C-C=O and the 4-bromophenyl group in E139 are necessary to confer anticonvulsant property that could lead to the design of new and improved anticonvulsant agents. Copyright © 2003 S. Karger AG, Basel.