T Cell Receptor-induced Activation and Apoptosis In Cycling Human T Cells Occur throughout the Cell Cycle

Previous studies have found conflicting associations between susceptibility to activation-induced cell death and the cell cycle in T cells. However, most of the studies used potentially toxic pharmacological agents for cell cycle synchronization. A panel of human melanoma tumor-reactive T cell lines, a CD8+ HER-2/neu-reactive T cell clone, and the leukemic T cell line Jurkat were separated by centrifugal elutriation. Fractions enriched for the G0–G1, S, and G2–M phases of the cell cycle were assayed for T cell receptor-mediated activation as measured by intracellular Ca2+ flux, cytolytic recognition of tumor targets, and induction of Fas ligand mRNA. Susceptibility to apoptosis induced by recombinant Fas ligand and activation-induced cell death were also studied. None of the parameters studied was specific to a certain phase of the cell cycle, leading us to conclude that in nontransformed human T cells, both activation and apoptosis through T cell receptor activation can occur in all phases of the cell cycle.

System Costs of Variable Renewable Energy in the European Union. Bruges European Economic Policy (BEEP) Briefings 37/2015

To shift to a low-carbon economy, the EU has been encouraging the deployment of variable renewable energy sources (VRE). However, VRE lack of competitiveness and their technical specificities have substantially raised the cost of the transition. Economic evaluations show that VRE life-cycle costs of electricity generation are still today higher than those of conventional thermal power plants. Member States have consequently adopted dedicated policies to support them. In addition, Ueckerdt et al. (2013) show that when integrated to the power system, VRE induce supplementary not-accounted-for costs. This paper first exposes the rationale of EU renewables goals, the EU targets and current deployment. It then explains why the LCOE metric is not appropriate to compute VRE costs by describing integration costs, their magnitude and their implications. Finally, it analyses the consequences for the power system and policy options. The paper shows that the EU has greatly underestimated VRE direct and indirect costs and that policymakers have failed to take into account the burden caused by renewable energy and the return of State support policies. Indeed, induced market distortions have been shattering the whole power system and have undermined competition in the Internal Energy Market. EU policymakers can nonetheless take full account of this negative trend and reverse it by relying on competition rules, setting-up a framework to collect robust EU-wide data, redesigning the architecture of the electricity system and relying on EU regulators.

Operator, organizational, direct support, and general support maintenance manual : compressor, power driven rotary 2 stage, 250 cfm, 100 psi, 4 cylinder, 2 cycle, DED, trailer mtd, 2 wheel (Ingersoll-Rand Co. model RMS-250), FSN 4310-471-3075.

"July 1972."

Operator and organizational maintenance manual : generator set, diesel engine, precise power, 100 kw, AC, 120/208V, 240/416V, 3 phase, 60 cycle, at 1800 rpm, 83.3 kw, 120/208V, 240/416V, 3 phase, 50 cycle at 1500 rpm, skid mounted ....

"April 1961."

Operator's, manual : milling machine, ram type, swivel head, plain table, power feed, 1 1/2 horsepower, 110-volt, 60-cycle, single-phase (Van Norman Machine Company models IR-3-22 and IRQ-3-22) (3417-624-4254).

"March 1967."

Field and depot maintenance manual : generator set, diesel engine precise power; 100 KW, AC, 120/208 V, 240/416 V, 3 phase, 60 cycle at 1800 RPM, 83.3 KW, 120/208 V 240/416 V, 3 phase, 50 cycle at 1500 RPM; skid mounted (Detroit Diesel Divn. General Motors Corp. model 6910A) FSN 6115-798-3444.

Includes index.

Organizational, DS, GS and depot maintenance repair parts : motor-generator-power supply, 30 KW, input 60 cycle; output, 400 cycle (Hollingsworth models JH-32) ... model JH-32G (FSN 6125-506-3014).

Includes index.

Operator, organizational, direct and general support, and depot maintenance manual : motor generator power supply, generator - 60 KW, AC, 120/208V, 240/416V, 3 phase, 4 wire service, 400 cycle, DC component output, 28V, 10 amp, motor input, AC, 120/208V, 240/416V, 3 phase, 60 cycle, skid mounted (John R. Hollingsworth Co. model JHMX60G) FSN 61225-963-6712.

Includes index.

Operator, organizational, direct and general support maintenance manual : delousing outfit, power driven; gasoline engine, 4-cycle, air-cooled, 3600 RPM, 4.7 HP; 10 dusting guns, (Curtis Automotive Devices, Inc. model CDR 70000), FSN 4230-078-5455, (Curtis Dyna-Products Corporation model CDR 70000B), FSN 4230-935-9361.

Includes index.

Organizational, direct, and general support maintenance repair parts and special tools list : delousing outfit, power driven, gasoline engine, 4 cycle, air cooled, 3600 rpm, 4.7 hp, 10 dusting guns (Curtis Automotive Devices, Inc model CDR 70,000), FSN 4230-078-5455 ....

"December 1970."

Open-cycle magnetohydrodynamic electrical power generation /

Added t.p.: Magnitogidrodinamicheskoe preobrazovanie ėnergii otkrytyĭ t︠s︡ikl.

Variable Step Maximum Power Point Tracking for Photovoltaic Modules with Embedded Temperature Sensing

Thesis (Master's)--University of Washington, 2016-06

Estimating variable returns to scale production frontiers with alternative stochastic assumptions

Two stochastic production frontier models are formulated within the generalized production function framework popularized by Zellner and Revankar (Rev. Econ. Stud. 36 (1969) 241) and Zellner and Ryu (J. Appl. Econometrics 13 (1998) 101). This framework is convenient for parsimonious modeling of a production function with returns to scale specified as a function of output. Two alternatives for introducing the stochastic inefficiency term and the stochastic error are considered. In the first the errors are added to an equation of the form h(log y, theta) = log f (x, beta) where y denotes output, x is a vector of inputs and (theta, beta) are parameters. In the second the equation h(log y,theta) = log f(x, beta) is solved for log y to yield a solution of the form log y = g[theta, log f(x, beta)] and the errors are added to this equation. The latter alternative is novel, but it is needed to preserve the usual definition of firm efficiency. The two alternative stochastic assumptions are considered in conjunction with two returns to scale functions, making a total of four models that are considered. A Bayesian framework for estimating all four models is described. The techniques are applied to USDA state-level data on agricultural output and four inputs. Posterior distributions for all parameters, for firm efficiencies and for the efficiency rankings of firms are obtained. The sensitivity of the results to the returns to scale specification and to the stochastic specification is examined. (c) 2004 Elsevier B.V. All rights reserved.