Treatment of relapse after allogeneic bone marrow transplantation with reduced intensity conditioning (FLAG +/- Ida) and second allogeneic stem cell transplant

Acute leukaemias in relapse after allogeneic stem cell transplantation (SCT) respond poorly to donor leucocyte infusions (DLI) compared with chronic myeloid leukaemia (CML), at least in part because of faster disease kinetics. Fludarabine-containing 'non-myeloablative' chemotherapy followed by further allo SCT may offer more rapid and effective disease control. We report 14 patients with relapse after allo SCT for acute leukaemia [seven acute myeloid leukaemia (AML), five acute lymphoblastic leukaemia (ALL)] or refractory anaemia with excess blasts in transformation (RAEB-t, n = 2) treated with fludarabine, high-dose cytosine arabinoside (ara-C) and granulocyte colony-simulating factor (G-CSF) with (n = 10) or without (n = 2) idarubicin (FLAG +/- Ida) or DaunoXome (FLAG-X) (n = 2) and second allo SCT from the original donor. Donors were fully human leucocyte antigen (HLA) -matched in 13 cases with a single class A mismatch in one. Actuarial overall survival was 60% and disease-free survival was 26% at 58 months. Remissions after the second SCT were longer than those after the first bone marrow transplantation (BMT) in eight of the 13 assessable patients to date. Haematopoietic recovery was rapid. Transplants were well tolerated with no treatment-related deaths. The major complication was graft-versus-host disease (GvHD, acute >/= grade II-2 cases, chronic - eight cases, two limited, six extensive) although there have been no deaths attributable to this. FLAG +/- Ida and second allo SCT is a safe and useful approach and may be more effective than DLI in the treatment of acute leukaemias relapsing after conventional allo SCT.

Development of open models and tools for seismic risk assessment: application to Portugal

The exponential growth of the world population has led to an increase of settlements often located in areas prone to natural disasters, including earthquakes. Consequently, despite the important advances in the field of natural catastrophes modelling and risk mitigation actions, the overall human losses have continued to increase and unprecedented economic losses have been registered. In the research work presented herein, various areas of earthquake engineering and seismology are thoroughly investigated, and a case study application for mainland Portugal is performed. Seismic risk assessment is a critical link in the reduction of casualties and damages due to earthquakes. Recognition of this relation has led to a rapid rise in demand for accurate, reliable and flexible numerical tools and software. In the present work, an open-source platform for seismic hazard and risk assessment is developed. This software is capable of computing the distribution of losses or damage for an earthquake scenario (deterministic event-based) or earthquake losses due to all the possible seismic events that might occur within a region for a given interval of time (probabilistic event-based). This effort has been developed following an open and transparent philosophy and therefore, it is available to any individual or institution. The estimation of the seismic risk depends mainly on three components: seismic hazard, exposure and vulnerability. The latter component assumes special importance, as by intervening with appropriate retrofitting solutions, it may be possible to decrease directly the seismic risk. The employment of analytical methodologies is fundamental in the assessment of structural vulnerability, particularly in regions where post-earthquake building damage might not be available. Several common methodologies are investigated, and conclusions are yielded regarding the method that can provide an optimal balance between accuracy and computational effort. In addition, a simplified approach based on the displacement-based earthquake loss assessment (DBELA) is proposed, which allows for the rapid estimation of fragility curves, considering a wide spectrum of uncertainties. A novel vulnerability model for the reinforced concrete building stock in Portugal is proposed in this work, using statistical information collected from hundreds of real buildings. An analytical approach based on nonlinear time history analysis is adopted and the impact of a set of key parameters investigated, including the damage state criteria and the chosen intensity measure type. A comprehensive review of previous studies that contributed to the understanding of the seismic hazard and risk for Portugal is presented. An existing seismic source model was employed with recently proposed attenuation models to calculate probabilistic seismic hazard throughout the territory. The latter results are combined with information from the 2011 Building Census and the aforementioned vulnerability model to estimate economic loss maps for a return period of 475 years. These losses are disaggregated across the different building typologies and conclusions are yielded regarding the type of construction more vulnerable to seismic activity.

La soledad christiana : en que a la luz del cielo se consideran las eternas verdades, segun la idéa de los exercicios espirituales de mi santo padre Ignacio, para los que desean por ocho dias retirarse á ellos.

UANL

Solistas en el aula : ida y vuelta : trasatl??ntico

Disfrutar y entender la m??sica son conceptos inseparables que, a su vez, enlazan con la manera y la frecuencia con que se escucha la misma. Hace falta establecer la mejor manera de percibirla o el mejor momento para hacerlo, no existiendo una edad para iniciar el acercamiento a este fascinante y maravilloso mundo, si bien cuanto antes se empiece este proceso, m??s enriquecedor resultar??.

L'analisi de discrepàncies : una tècnica per a determinar la necessitat d'adaptacions curriculars en el context d'entorns educatius generals. 'El análisis de discrepancias : una técnica para determinar la necesidad de adaptaciones curriculares en el contexto de entornos educativos generales'.

Resumen basado en el del autor en catalán

Un viatge d'anada amb o sense tornada : població i migracions al món. 'Un viaje de ida con o sin vuelta : población y migraciones en el mundo'.

Resumen basado en el del documento en catalán

Teatro y matemáticas : un viaje de ida y vuelta.

resumen literal de la revista

Viaje de ida y vuelta : de la familia participante a molesto incordio, y ahora, salvavidas.

Se pone de manifiesto la desorientación de las familias en cuento a su responsabilidad educativa. Dicha desorientación viene motivada o por la falta de recursos, o por la falta de apoyos sociales. A su vez, se pone de manifiesto la idea de que los cambios producidos en el mundo laboral y en la movilidad social, motivan que las familias no sepan o no puedan desenvolverse en un marco social distinto al de antaño. Todo ello conduce a una reflexión sobre los cambios producidos en el binomio escuela-familia.

Galicia-El Salvador : viaje de ida y vuelta.

Una representación gallega de Educación sin Fronteras visita El Salvador para conocer el sistema de escuelas rurales administradas por padres y construidas sobre los pilares de la educación popular. Se detecta que es necesario establecer programas de formación para estas personas, con el objetivo de que conozcan el entorno legal y técnico y aprendan a manejar las herramientas de gestión. Por otro lado, se observa que la educación camina pareja a una realidad social caracterizada por la violencia. Por último, un maestro salvadoreño y una experta en educación de El Salvador visitan Galicia para intercambiar experiencias con sus homólogos.

Jazzcítric : músicas de ida y vuelta.

Se expone una experiencia en el aula de Música realizada con alumnos de 4º de ESO del IES Arabista, de Ribera de Carcaixent (Valencia). Su objetivo es explorar e investigar ritmos y melodías con el fin de realizar una composición colectiva de varias piezas que, una vez adaptadas por músicos, se recopilan en un disco. En el artículo, se describe el proceso de realización del proyecto.

Viajes de ida y vuelta de la ciencia ilustrada y su influencia en la educación colonial americana.

Resumen tomado de la revista