Hydrated myoglobin's anharmonic fluctuations are not primarily due to dihedral transitions.

To characterize the functionally important anharmonic motions of proteins, simulations of carboxymyoglobin (MbCO) dynamics have been performed during which dihedral transitions were prohibited. Comparison of torsionally restrained and unrestrained protein dynamics simulated at three levels of hydration and at temperatures ranging from 100 to 400 K suggests that hydration "catalyzes" protein mobility by facilitating collective anharmonic motions that do not require dihedral transitions. When dihedral transitions were prohibited, dehydrated MbCO, to a good approximation, exhibited only harmonic fluctuations, whereas hydrated MbCO exhibited both harmonic and anharmonic motions. The fluctuation of helix centers of mass also remained highly anharmonic in the torsionally restrained hydrated system. Atomic mean-square fluctuation at 300 K was reduced upon prohibition of dihedral transitions by only 28% and 10% for MbCO hydrated by 350 and 3830 water molecules, respectively.

Managing Recreational Impacts on the Northeast corner of the Lake Fayetteville Nature Trail in Fayetteville, AR

Increased population growth of the Northwest Corner of Arkansas is straining the natural resources of the Lake Fayetteville Nature Trail, Fayetteville, AR. Recreational activities conducted on this single track multi-use trail are mountain biking, walking, jogging and wildlife viewing. Impacts evident on the NE section of the trail consist of erosion, vegetation, wildlife and conflict disturbances. Throughout this paper recommendations of management solutions and maintenance ideas are presented. Control of recreation impacts will help the longevity of the trail and maintain the aesthetics for present and future trail users.

Clipping from The Harvard Bulletin, on discovery of southeast corner of original Harvard College building during subway excavations, 1910.

Contains prints of floor plans of Harvard College used for publication by Samuel E. Morison.

[Estimates from Walton & Moore for the raising and altering of seats in the anatomical room, and for repairing the lower room, northwest corner of the College House], 2 December 1806

The estimate includes projected costs for the materials and labor required for each renovation. The anatomical room needed its circular seats raised and altered. The renovation of the lower room included making new window frames and sashes (including replacing glass), installing new doors, and repairing the floors.

EU visa-liberalisation for Turks: just around the corner? EPC Commentary, 3 May 2016

At the 18 March EU-Turkey Migration Summit EU leaders pledged to lift visa requirements for Turkish citizens travelling to the Schengen zone by the end of June 2016 if Ankara met the required 72 benchmarks. On 4 May the European Commission will decide whether or not Turkey has done enough. The stakes are high because Turkey has threatened to cancel the readmission agreement, which is central to the success of the migration deal, if the EU fails to deliver.

Northwest corner

On verso: A.L. Colton, Photographer, Ann Arbor, Michigan. Views of the State University a Specialty

State Street. South West [southwest] Corner of Campus. Methodist Church in distance

Gentleman posing by lamppost