Deployment on GPUs of an application in computational atomic physics

This paper describes the deployment on GPUs of PROP, a program of the 2DRMP suite which models electron collisions with H-like atoms and ions. Because performance on GPUs is better in single precision than in double precision, the numerical stability of the PROP program in single precision has been studied. The numerical quality of PROP results computed in single precision and their impact on the next program of the 2DRMP suite has been analyzed. Successive versions of the PROP program on GPUs have been developed in order to improve its performance. Particular attention has been paid to the optimization of data transfers and of linear algebra operations. Performance obtained on several architectures (including NVIDIA Fermi) are presented.

The role of SRC-CAS interactions in cellular transformation:ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation

Several lines of evidence indicate that the adapter molecule p130CAS (crk-associated substrate (CAS)) is required for src-mediated cellular transformation. CAS has been shown to be heavily tyrosine-phosphorylated in src-transformed cells, and genetic variants of src that are deficient in CAS binding are also unable to mediate cellular transformation. In this report, we investigated whether CAS phosphorylation and/or its association with src are required elements of the transformation process. Expression of the carboxy-terminal src binding domain of CAS in Rat 1 fibroblasts expressing a temperature-sensitive allele of v-src inhibited the formation of src-CAS complexes and also inhibited tyrosine phosphorylation of CAS. However, expression of this protein had no effect on morphological transformation, src-mediated actin rearrangements, or anchorage-independent growth of these cells when grown at the src-permissive temperature. Thus, the ability of activated src to mediate cellular transformation is either largely independent of endogenous CAS phosphorylation and/or its association with CAS or, alternatively, the carboxy-terminus of CAS may substitute for endogenous CAS in the process of src-mediated transformation.

Measuring specific parameters in pretensioned concrete members using a single testing technique

Pretensioned concrete members are designed and manufactured by using at least two materials: concrete and prestressing reinforcement. Also, two main stages must be considered: prestress transfer and member loading. Hence, the behavior of these members depends strongly on the reinforcement-to-concrete bond performance and prestress losses. In this paper, a testing technique to measure the specific parameters related with the involved phenomena is presented. The testing technique is based on the analysis of series of specimens varying in embedment length to simulate several cross sections at only one end of a pretensioned concrete member. Each specimen is characterized by means of the sequential release of the prestress transfer (detensioning) and the pull-out (loading) operation. The test provides data on prestressing force, transmission length (initial and long-term), anchorage length (without and with slip), reinforcement slips, bond stresses, longitudinal concrete strains, concrete modulus of elasticity, and prestress losses (instantaneous and time-dependent).

The Characteristics of Wave Impacts on an Oscillating Wave Surge Converter

Wave impacts on an Oscillating Wave Surge Converter are examined using experimental and numerical methods. The mechanics of the impact event are identified experimentally with the use of images recorded with a high speed camera. It is shown that it is the device which impacts the wave rather than a breaking wave impacting the device. Numerical simulations using two different approaches are used to further understand the issue. Good agreement is shown between numerical simulations and experimental measurements at 25th scale.

Strengthening timber beams with near surface mounted carbon fiber reinforced polymer rods

Many timber structures may require strengthening due to either decay and aging or an increase of load. This paper presents an experimental study in which eleven timber beams were tested, including three unstrengthened reference beams and eight beams strengthened with NSM CFRP bars. The test parameters include the position of NSM (tensile face or the bottom of the sides), the number of CFRP bars (1 or 2), and additional anchorage of NSM CFRP bars (steel wire U anchors or CFRP U strips). The test results show that the ultimate flexural strength of the timber beams were increased by 14%∼85% with an average of 47% due to NSM CFRP bar strengthening. Their deflection corresponding to the peak load was increased by 33% in average.

Novel manually made NSM FRP (MMFRP) bars for shear strengthening of RC beams

This paper presents an experimental study evaluating the effectiveness of the Near Surface Mounted (NSM) technique with innovative manually made FRP bars (MMFRP) for shear strengthening of RC beams. RC beams designed to fail in shear were tested in three-point bending. To delay the onset of MMFRP bar debonding, a new anchorage is also developed and tested. This paper reports the results of a series of tests on simply supported rectangular RC beams, strengthened in shear with MMFRP bar either with or without the proposed anchorage. The load-deflection responses of all test beams are plotted, in addition to selected strain results. Performance and the failure modes of the test beams are presented and discussed in this paper. The proposed MMFRP bars and end anchorage enhanced the shear capacity between 25 to 48% over the control specimen. Furthermore, the adoption of the proposed end anchorage of MMFRP bars significantly enhanced the ductility of the test specimens.

A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression

Aberrant activation of Wnt/β-catenin signaling, resulting in the expression of Wnt-regulated oncogenes, is recognized as a critical factor in the etiology of colorectal cancer. Occupancy of β-catenin at promoters of Wnt target genes drives transcription, but the mechanism of β-catenin action remains poorly understood. Here, we show that CARM1 (coactivator-associated arginine methyltransferase 1) interacts with β-catenin and positively modulates β-catenin-mediated gene expression. In colorectal cancer cells with constitutively high Wnt/β-catenin activity, depletion of CARM1 inhibits expression of endogenous Wnt/β-catenin target genes and suppresses clonal survival and anchorage-independent growth. We also identified a colorectal cancer cell line (RKO) with a low basal level of β-catenin, which is dramatically elevated by treatment with Wnt3a. Wnt3a also increased the expression of a subset of endogenous Wnt target genes, and CARM1 was required for the Wnt-induced expression of these target genes and the accompanying dimethylation of arginine 17 of histone H3. Depletion of β-catenin from RKO cells diminished the Wnt-induced occupancy of CARM1 on a Wnt target gene, indicating that CARM1 is recruited to Wnt target genes through its interaction with β-catenin and contributes to transcriptional activation by mediating events (including histone H3 methylation) that are downstream from the actions of β-catenin. Therefore, CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation, and may thereby represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/β-catenin signaling.

Finding ‘Good Friday’ An explorative study into the sedimentary structures left from the Good Friday tsunami

Senior thesis written for Oceanography 444

Amarração de plataformas offshore flutuantes com cabos de poliéster

Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização de Estruturas

Effect of hole drilling at the overlap on the strength of single-lap joints

Bonded unions are gaining importance in many fields of manufacturing owing to a significant number of advantages to the traditional fastening, riveting, bolting and welding techniques. Between the available bonding configurations, the single-lap joint is the most commonly used and studied by the scientific community due to its simplicity, although it endures significant bending due to the non-collinear load path, which negatively affects its load bearing capabilities. The use of material or geometric changes in single-lap joints is widely documented in the literature to reduce this handicap, acting by reduction of peel and shear peak stresses at the damage initiation sites in structures or alterations of the failure mechanism emerging from local modifications. In this work, the effect of hole drilling at the overlap on the strength of single-lap joints was analyzed experimentally with two main purposes: (1) to check whether or not the anchorage effect of the adhesive within the holes is more preponderant than the stress concentrations near the holes, arising from the sharp edges, and modification of the joints straining behaviour (strength improvement or reduction, respectively) and (2) picturing a real scenario on which the components to be bonded are modified by some external factor (e.g. retrofitting of decaying/old-fashioned fastened unions). Tests were made with two adhesives (a brittle and a ductile one) varying the adherend thickness and the number, layout and diameter of the holes. Experimental testing showed that the joints strength never increases from the un-modified condition, showing a varying degree of weakening, depending on the selected adhesive and hole drilling configuration.

Estudo de atirantamentos ancorados no plano perpendicular às fachadas de Alvenaria. Análise de proposta de dimensionamento

O conceito de atirantamento surgiu no contexto de promover a interação global dos edifícios, nomeadamente, estabelecer as referidas ligações, de modo a prevenir o derrubamento para o exterior das paredes de fachada, perante a ocorrência de ação sísmica ou assentamento das fundações. Neste sentido, o presente trabalho tem como objetivo, estudar o comportamento dos atirantamentos ancorados no plano perpendicular das fachadas, quando solicitados à tração. No entanto, como as alvenarias são elementos heterogéneos, houve necessidade de desarticular os atirantamentos e estudar cada uma das partes que o compõe: tirantes injetados em alvenarias e sistemas de ancoragem. Em primeiro lugar, foi elaborado um estudo preliminar sobre tirantes injetados em alvenarias, o qual incidiu no seu dimensionamento, na análise de sensibilidade, apresentação de um caso de estudo e comparação de resultados. Numa segunda fase fez-se uma revisão bibliográfica dos tipos de Sistemas de Ancoragens mais comuns, onde foram mencionados alguns aspetos, nomeadamente a importância, o objetivo e condições da sua aplicação. Por último, associaram-se as duas componentes e foram estudados os Atirantamentos. Fezse um estudo da sua utilização e do seu interesse de aplicação. Foi também analisada uma forma de metodologia de dimensionamento, quando inseridos em alvenarias de tijolo e pedra. Finalizado este estudo foram traçadas as conclusões e sugeridas perspetivas futuras.