Zoneamento acústico urbano e mapeamento de níveis sonoros na zona central de Rio Claro (SP): diretrizes para o gerenciamento do ruído integrado ao planejamento ambiental urbano

Considering the growing degradation of the urban environmental quality resulting from the progressive sound pollution increase, as well as the consequent harmful effects about the human health, the present study had its central objective the argument and management tools implementation of the urban noise that can be integrated to the environmental planning in the city of Rio Claro (SP). Therefore, normative and bibliographical revisions were developed, that made feasible the directives of control argument and prevention of the urban noise, as well as the technical procedures of sound levels and evaluation’s definition and especially about the criteria applicable for the elaboration of an urban acoustic zoning methodology. Among the main results obtained detach: (1) the applicable legislation to the management of urban noise’s synthesis and argument; (2) the methodology of urban acoustic zoning development and (3) its implementation to determined areas of Rio Claro (SP) with the (4) respective cartography representation; (5) the mapping of sound levels in the central zone of Rio Claro (SP), (6) the obtaining and analysis of noise describers (LAeq, Lmáx, L10, L50, L90, Lmin and TNI) and the subsequent (7) acoustic maps elaboration for the main describers.

Seleção de áreas potenciais para implantação da zona de processamento e exportação de Fernandópolis - SP utilizando geotecnologia

The implementation of an Export and Processing Zone (ZEPs) brings several benefits to the local, state and federal economy, but often, only socioeconomic factors are considered, apart from several other factors that should be analyzed, such as the environment. In this context of industrialization and the struggle for sustainable development, this work propose to incorporate the environmental variable in the decision process for establishing industrial areas, in particular, the ZPE in the city of Fernandópolis, São Paulo state, Brazil, by examining several physical and environmental factors such as slope intervals, geological features, pedological factors and land use. Developed using a multicriteria analysis, a model has been elaborated, where these factors have received a proportional value according with their importance, supported by a GIS tool (Geographical Information System) and remote sensing products, such as images from CBERS satellite and SRTM radar, showing the suited areas for industrial activities, considering environmental conditions. This model may assist to take better decision about the ZPE implementation area and to reduce the negative environmental impacts that would result of poorly planned locations

Caracterização estrutural da Zona de Falha de Cássia-MG

A Zona de Falha de Cássia constitui um feixe de falhas de direção preferencial NW-SE e aproximadamente 2 km de largura. Dados de campo, petrográficos e microestruturais evidenciam uma longa história deformacional da zona de falha. Assim, foram caracterizadas três fases de atividade/movimentação da Zona de Falha de Cássia. A primeira fase (précambriana) é caracterizada por deformação em regime dúctil, acarretando na geração de milonitos formados em condições metamórficas de fácies xisto verde. Este é o estágio de formação da falha, apresentando caráter transcorrente oblíqua, com movimentação sinistral inversa. A segunda fase corresponde a uma reativação da zona de falha como uma falha normal, com bloco alto a NE e bloco baixo a SW da referida estrutura. Seu registro é dado pela ocorrência localizada de brechas e cataclasitos. Este episódio de deformação eminentemente rúptil é correlacionado com o Soerguimento do Alto Paranaíba, o que indica movimentação da falha no Neocretáceo. A terceira e última fase é marcada pela formação de depósitos sedimentares plio-pleistocênicos compostos por brecha sedimentar de leques aluviais e sedimentos argilosos lacustres. Tais depósitos são interpretados como originados pelo represamento da drenagem subatual e conseqüente mudança do nível de base local, em decorrência de uma reativação da Zona de Falha de Cássia. O referido pacote sedimentar apresenta-se localmente cortado por fraturas, zonas brechadas e falhas, caracterizando atividade neotectônica na região. Além disso, foi mostrada a forte influência da zona de falha no desenvolvimento da paisagem da região, sendo constatada a inversão do relevo e da drenagem na área estudada.

Hipertonicidade muscular e confecção de próteses totais pela técnica da zona neutra: relato de caso clínico

Introduction: the oral rehabilitation in edentulous patients using removable complete dentures is a classic treatment, easily accessible, and presenting satisfactory results. However, to succeed in this type of treatment, stability is an extremely important factor. The neutral zone technique for the production of complete dentures determines the oral cavity space for the positioning of teeth and denture base that provide a neutralization of the forces delivered by lips, cheeks, and tongue, providing better stability and retention of prostheses, which is indicated in cases with history of difficulties in adapting the conventional mandibular denture. Objective and case report: this paper aimed to describe a clinical case report of the oral rehabilitation of a patient with paraprosthetic muscles hypertonicity through removable complete dentures produced by the neutral zone technique, using condensation silicone. Final considerations: the use of condensation silicone for the development of the neutral zone technique showed to be a good alternative for the development of this clinical case, providing satisfactory stability and retention of the complete mandibular denture.

Os efeitos da manipulação do sistema proprioceptivo na locomoção de pessoas com doença de Parkinson com e sem congelamento da marcha: desenvolvimento, otimização e aplicabilidade de um sistema de vibração muscular

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Alternate current biosusceptometry for the assessment of gastric motility after proximal gastrectomy in rats: a feasibility study

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeitos da prematuridade sobre o desenvolvimento de lactentes

The aim of this study was to evaluate the behavioral aspects of infants relating them to prematurity. A total of 130 lactentes were evaluated every month during the first year of life, employing the Operational Portage Inventory . Group 1, 56 newborns with no life risk at birth and Group 2, 74 premature babies, those that was born until 37 gestation weeks. The outcomes obtained showed that the premature babies (Group 2) presented a totally different performance than Group 1 in 68% of the analyses made, especially for motor development, cognition and socialization. The outcomes are in accord to the ones obtained in the literature, which indicate prematurity as one of the most harmful proximal conditions for the development of infants.

Morfologia e desenvolvimento do sistema reprodutor em três espécies de Isoptera

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Design Participativo para a Sustentabilidade: desenvolvimento de painéis modulares para fechamentos, utilizando bambu associado com terra e resíduos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Zonas Estratégicas e Estruturais para os Trânsitos Ilícitos (ZEETI): desafios à zona de paz na América do Sul

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

AÇÃO REGULATÓRIA DO GnRH NO DESENVOLVIMENTO EMBRIONÁRIO PRECOCE E VITRIFICAÇÃO DE EMBRIÕES SUÍNOS PELO MÉTODO DE MICROGOTA (ROLE OF GnRH DURING EARLY EMBRYONIC DEVELOPMENT AND DEVELOPMENT OF SWINE EMBRYOS FOLLOWING VITRIFICATION BY MICRODROPLET METHOD)

The objective of this study was to investigate the role of GnRH on the preimplantation development of mouse embryos in vitro. GnRH-I, GnRH-II, and GnRH agonists: Des-Gly, Des-Trp and histrelin did not improve embryo development. However, treatment with the specific GnRH antagonist SB-75 blocked embryo development at morula stage. The inhibition of embryo development by SB-75 could be rescued by the addition of histrelin. To determine which intracellular signaling cascade is involved following binding of GnRH to the GnRHR, embryos were cultured in the presence of specific PKC (GFX) or PKA (SQ22536) inhibitors. The PKC inhibitor blocked embryo development at a similar stage as SB-75, whereas SQ22536 had an inhibitory effect, diminishing blastocyst formation and hatched rates. There are evidences that GnRH has an essential autocrine effect on mouse embryonic development via GnRHR, probably by activating PKC signaling cascade while the inhibition of the GnRH signaling does not activate apoptotic mechanisms involving caspase-3. In another experiment, development in vitro of embryos from Chinese Meishan (M) and occidental white crossbred (WC) females were investigated after improving the vitrification protocol for pig embryos. Efficient cryopreservation of zona pellucida-intact porcine embryos and studies of the difference among breeds could greatly impact the swine industry. The percentage of embryos surviving 24 h after cryopreservation without lysis or degeneration was higher for M (72%) than WC (44%). However, in vitro development of embryos that survived cryopreservation was not different between M and WC at the expanded (64%) or hatched (22%) blastocyst stages. Developmental rates were significantly higher for control embryos than frozen embryos from both breeds at expanded blastocyst stage, but not at hatched blastocyst stage. Rates of expanded blastocyst formation did not differ between M and WC control embryos (98 and 95%, respectively). With a new procedure to warm vitrified pig embryos, the survival rates may be improved. The optimal stages to vitrify pig embryos using the microdroplet method ranges from late compact morula to early expanded blastocyst. The results suggest that M embryos have a higher capacity to survive the vitrification process than WC embryos. O objetivo do presente estudo foi investigar a importância do GnRH no desenvolvimento embrionário precoce em camundongos. GnRH-I, GnRH-II e os GnRH agonistas: Des-Gly, Des-Trp e histrelina não incrementaram o desenvolvimento embrionário. Entretanto, o tratamento com SB-75, um antagonista específico do GnRH, bloqueou o desenvolvimento embrionário no estádio de mórula. A inibição do desenvolvimento embrionário pelo SB-75 pôde ser revertida com a adição de histrelina. Para determinar a cascata do sinal intracelular desencadeada pela ligação do GnRH com o seu receptor, embriões foram cultivados na presença de inibidores específicos da PKC (GFX) e da PKA (SQ22536). O inibidor da PKC bloqueou o desenvolvimento embrionário em estádio similar ao bloqueio mediado pelo SB- 75, enquanto o SQ22536 teve efeito inibitório diminuindo a formação de blastocisto e taxas de eclosão. Os resultados sugerem que o GnRH tem um efeito autócrino essencial no desenvolvimento embrionário através do GnRHR, provavelmente, ativando a cascata da PKC. Por outro lado, a inibição do sinal do GnRH não ativa mecanismos apoptóticos que involvam caspase-3. Em outro experimento, foi investigado o desenvolvimento in vitro de embriões da raça Meishan (M) e branco cruzado (WC) após vitrificação pelo método microgota. O desenvolvimento de protocolos eficientes para criopreservação de embriões suínos com a zona pelúcida intacta e a avaliação das diferenças entre raças pode ter um significativo impacto na suinocultura. A percentagem de embriões que sobreviveram à criopreservação depois de 24 h foi maior na M (72%) do que na WC (44%). No entanto, o desenvolvimento in vitro dos embriões que sobreviveram à criopreservação não foi diferente entre M e WC nos estádios de blastocisto expandido (64%) ou eclodido (22%). Os índices de desenvolvimento foram significativamente mais altos para os embriões controle do que para os embriões vitrificados nas duas raças no estádio de blastocisto expandido, porém não foram diferentes para o estádio de blastocisto eclodido. A formação de blastocisto expandido não diferiu entre os embriões controle M e WC (98 e 95%, respectivamente). Com o novo procedimento (“hot warm”) para descongelar embriões vitrificados pelo método de microgota, pode-se aumentar dos índices de sobrevivência. Os melhores estádios embrionários para a vitrificação de embriões suínos variam de mórula compacta tardia até blastocisto expandido inicial. Os resultados sugerem que embriões M têm mais capacidade de sobreviver ao processo de vitrificação do que embriões WC.

Distinct mechanisms underlie adaptation of proximal tubule Na+/H+ exchanger isoform 3 in response to chronic metabolic and respiratory acidosis

The Na+/H+ exchanger isoform 3 (NHE3) is essential for HCO3- reabsorption in renal proximal tubules. The expression and function of NHE3 must adapt to acid-base conditions. The goal of this study was to elucidate the mechanisms responsible for higher proton secretion in proximal tubules during acidosis and to evaluate whether there are differences between metabolic and respiratory acidosis with regard to NHE3 modulation and, if so, to identify the relevant parameters that may trigger these distinct adaptive responses. We achieved metabolic acidosis by lowering HCO3- concentration in the cell culture medium and respiratory acidosis by increasing CO2 tension in the incubator chamber. We found that cell-surface NHE3 expression was increased in response to both forms of acidosis. Mild (pH 7.21 +/- 0.02) and severe (6.95 +/- 0.07) metabolic acidosis increased mRNA levels, at least in part due to up-regulation of transcription, whilst mild (7.11 +/- 0.03) and severe (6.86 +/- 0.01) respiratory acidosis did not up-regulate NHE3 expression. Analyses of the Nhe3 promoter region suggested that the regulatory elements sensitive to metabolic acidosis are located between -466 and -153 bp, where two consensus binding sites for SP1, a transcription factor up-regulated in metabolic acidosis, were localised. We conclude that metabolic acidosis induces Nhe3 promoter activation, which results in higher mRNA and total protein level. At the plasma membrane surface, NHE3 expression was increased in metabolic and respiratory acidosis alike, suggesting that low pH is responsible for NHE3 displacement to the cell surface.

The influence of interdental spacing on the detection of proximal caries lesions in primary teeth

The aim of this study was to investigate the influence of interdental spacing on the performance of proximal caries detection methods in primary molars. In addition, aspects related to temporary tooth separation with orthodontic separators were evaluated. The proximal spaces between the posterior primary teeth (n = 344) of 76 children (4-12 years old) were evaluated before and after temporary separation. Stainless steel strips with different standardized thicknesses were used to measure the presence of biological spacing and the spacing obtained after temporary separation with orthodontic rubber rings. First, the presence of proximal caries lesions was assessed by visual inspection, bitewing radiographs and a pen-type laser fluorescence device (DIAGNOdent pen). Visual inspection after temporary separation with separators was the reference standard method in checking the actual presence of caries. Multilevel analyses were performed considering different outcomes: the performance of the methods in detecting caries lesions and the spacing after temporary separation. The spacing did not influence the performance of the caries detection methods. The maximum spacing obtained with temporary tooth separation was 0.80 mm (mean +/- standard deviation = 0.46 +/- 0.13 mm). The temporary separation was more effective in the upper arch and less effective when an initial biological interdental spacing was present. The biological interdental spacing does not influence the performance of proximal caries detection methods in primary molars, and temporary tooth separation provides spacing narrower than 1.0 mm.

Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure

Inoue BH, dos Santos L, Pessoa TD, Antonio EL, Pacheco BPM, Savignano FA, Carraro-Lacroix LR, Tucci PJF, Malnic G, Girardi ACC. Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure. Am J Physiol Regul Integr Comp Physiol 302: R166-R174, 2012. First published October 26, 2011; doi:10.1152/ajpregu.00127.2011.-Heart failure (HF) is associated with a reduced effective circulating volume that drives sodium and water retention and extracellular volume expansion. We therefore hypothesized that Na(+)/H(+) exchanger isoform 3 (NHE3), the major apical transcellular pathway for sodium reabsorption in the proximal tubule, is upregulated in an experimental model of HF. HF was induced in male rats by left ventricle radiofrequency ablation. Sham-operated rats (sham) were used as controls. At 6 wk after surgery, HF rats exhibited cardiac dysfunction with a dramatic increase in left ventricular end-diastolic pressure. By means of stationary in vivo microperfusion and pH-dependent sodium uptake, we demonstrated that NHE3 transport activity was significantly higher in the proximal tubule of HF compared with sham rats. Increased NHE3 activity was paralleled by increased renal cortical NHE3 expression at both protein and mRNA levels. In addition, the baseline PKA-dependent NHE3 phosphorylation at serine 552 was reduced in renal cortical membranes of rats with HF. Collectively, these results suggest that NHE3 is upregulated in the proximal tubule of HF rats by transcriptional, translational, and posttranslational mechanisms. Enhanced NHE3-mediated sodium reabsorption in the proximal tubule may contribute to extracellular volume expansion and edema, the hallmark feature of HF. Moreover, our study emphasizes the importance of undertaking a cardiorenal approach to contain progression of cardiac disease.

Objetivos e métodos de preço no varejo: estudo na zona sul de São Paulo

No varejo existe uma complexa tarefa na formulação das estratégias de precificação. Enquanto os objetivos de preço fornecem uma direção geral para ação, os métodos de precificação são procedimentos pelos quais as organizações atingem suas decisões de preços. O escopo deste trabalho é explorar os objetivos de preços do varejo juntamente com os métodos que adota para precificar, investigando se os objetivos estão associados aos métodos. A pesquisa mostra que as empresas da amostra estão fundamentalmente perseguindo objetivos quantitativos em vez de qualitativos, com uma forte ênfase na realização de vendas e lucros, seguido pelo desenvolvimento de mercado. Outro ponto relevante na discussão das estratégias de varejo: as empresas da amostra parecem dar menor importância a métodos de orientação ao cliente e empregam com mais frequência o método tradicional de custos.