Bizarría guipuzcoana y sitio de Fuenterrabía, 1474-1521, 1635-1638 : apuntaciones históricas / de Antonio Bernal de O'Reilly.

VYF VYF

Resumen historico de la portentosa llegada de la imagen del Smo. Christo del Salvador a los muros de la ciudad de Valencia ... en el año 1250, sacado de los escritores de la historia de dicha ciudad ... que publicaron D. Juan Bautista Ballester ... en el año 1672 ... y D. Josef Vicente Ortí y Mayor en el año 1709

Sign.: [A]-B2, C8

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by proteolysis of its inhibitory subunit (IκB) via the ubiquitin-proteasome pathway. Signal-induced phosphorylation of IκBα by a large multisubunit complex containing IκB kinases is a prerequisite for ubiquitination. Here, we show that FWD1 (a mouse homologue of Slimb/βTrCP), a member of the F-box/WD40-repeat proteins, is associated specifically with IκBα only when IκBα is phosphorylated. The introduction of FWD1 into cells significantly promotes ubiquitination and degradation of IκBα in concert with IκB kinases, resulting in nuclear translocation of NF-κB. In addition, FWD1 strikingly evoked the ubiquitination of IκBα in the in vitro system. In contrast, a dominant-negative form of FWD1 inhibits the ubiquitination, leading to stabilization of IκBα. These results suggest that the substrate-specific degradation of IκBα is mediated by a Skp1/Cull 1/F-box protein (SCF) FWD1 ubiquitin-ligase complex and that FWD1 serves as an intracellular receptor for phosphorylated IκBα. Skp1/Cullin/F-box protein FWD1 might play a critical role in transcriptional regulation of NF-κB through control of IκB protein stability.

Agricultura aterrazada y clasificaciones de Zonas Desfavorecidas ¿cuál es su futuro con la reforma de la PAC 2014?

El 54,4% de la Superficie Agrícola Utilizada en la Unión Europea-27 se clasifica como Zona Desfavorecida. En estas áreas, los agricultores pueden ingresar de media un 27% menos por unidad de trabajo anual que aquellos que cultivan la tierra en zonas no desfavorecidas. Las directivas europeas, nacionales y autonómicas que se ocupan de una u otra manera de los espacios de cultivo en las “Zonas Desfavorecidas de Montaña”, en las “Zonas Desfavorecidas Intermedias” y en las “Zonas Afectadas por Dificultades Específicas”, y en las que la técnica del aterrazamiento suele estar presente, son bastante numerosas. Sin embargo, la eficacia de esas políticas ha sido muy desigual, dependiendo del diferente contexto ambiental, social y económico del país europeo que se estudie y, sobre todo, de la categoría a la que puedan acogerse las explotaciones agrícolas. Pero, además, el territorio europeo cuenta con una extensión de cultivos en “Áreas de Montaña”, también en general aterrazadas, que no han sido incluidas en las categorías citadas, cuyos agricultores no pueden beneficiarse de esas ayudas específicas, pese a afrontar los mismos problemas. España es el país más afectado de la Unión Europea, con un 16,19% de su área de montaña excluida, principalmente en la Comunidad Valenciana, Cataluña y Aragón. A partir de 2014, como consecuencia de las directrices que se deriven de la reforma de la Política Agrícola Común, estos territorios experimentarán un nuevo cambio. Entre ellos, se contempla la posibilidad de que los Estados Miembros puedan destinar mayores ayudas a las zonas desfavorecidas y elaborar subprogramas temáticos para las zonas de montaña. Por otro lado, se establecerá una nueva delimitación de “Zonas con Desventajas Naturales” (que sustituirá a las “Zonas Desfavorecidas Intermedias”), basada en ocho criterios biofísicos, con efectos a partir de 2018. Dado que los Estados Miembro deberán elaborar nuevos mapas con las zonas a delimitar, y que hasta el momento España es uno de los países que menor cuantía económica destina a estas zonas, presentamos una revisión de la problemática de estos territorios.

I. Sermons, 1709-1724

This series contains seventeen handwritten sermons composed by Nicholas Sever and delivered in the Boston area between 1709 and 1722. Following the completion of his Master's degree at Harvard in 1704, Sever preached in towns around New England including Haverhill in 1709, Dover, New Hampshire (where he was ordained in 1711 and remained until 1715), and in Cambridge as part of his duties as a Harvard Tutor between 1716 and 1728. During these years, Sever also filled in for ministers in nearby parishes. Sever's sermons reflect these engagements, and he occasionally noted the dates and locations where the sermons were delivered in the margin of the first page of the sermon.

Deed of sale, 1709/10 March 15

Handwritten deed between grantor Samuel Gookin and grantee Andrew Bordman for property in Cambridge Neck. The deed is also signed by Hannah Gookin. The red wax seals of Gookin and Bordman are still visible on the document.

Sermons : manuscript, 1709-1722

64 sermons on verses from John, Proverbs, Revelations, Matthew, and other books of the Bible, with notation of dates and places delivered in and around Boston.

An account of the capture of St. Johns by the French : manuscript, 1709 May 14

Manuscript narrative, signed by John Campion and Joseph Knills; dated at Carbonnear Is., Newfoundland, 14 May 1709.

Central & Eastern Africa, 1635 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Aethiopia superior vel interior, vulgo Abissinorum sive Presbiteri Ioannis imperium. It was published by Guiljelmum et Johannem Blaeu in 1635. Scale [ca. 1:12,600,000]. Covers Central and Eastern Africa. Map in Latin.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Sinusoidal projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown pictorially. Includes notes, illustrations of animals, and ornamental cartouche. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Lille, France, ca. 1709 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan de la ville et citadelle de Lille, P. v. Call fecit. It was published by chez Anna Beek ca. 1709. Scale [ca. 1:9,281]. Covers Citadelle de Lille and a portion of Lille, France. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, Universal Transverse Mercator (UTM) Zone 31N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortifications, defenses, and lines of fire, ground cover, and more. Relief shown by hachures. Includes also index.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.