Female sex hormones mediate the allergic lung reaction by regulating the release of inflammatory mediators and the expression of lung E-selectin in rats

Background: Fluctuations of estradiol and progesterone levels caused by the menstrual cycle worsen asthma symptoms. Conflicting data are reported in literature regarding pro and anti-inflammatory properties of estradiol and progesterone.Methods: Female Wistar rats were ovalbumin (OVA) sensitized 1 day after resection of the ovaries (OVx). Control group consisted of sensitized-rats with intact ovaries (Sham-OVx). Allergic challenge was performed by aerosol (OVA 1%, 15 min) two weeks later. Twenty four hours after challenge, BAL, bone marrow and total blood cells were counted. Lung tissues were used as explants, for expontaneous cytokine secretion in vitro or for immunostaining of E-selectin.Results: We observed an exacerbated cell recruitment into the lungs of OVx rats, reduced blood leukocytes counting and increased the number of bone marrow cells. Estradiol-treated OVx allergic rats reduced, and those treated with progesterone increased, respectively, the number of cells in the BAL and bone marrow. Lungs of OVx allergic rats significantly increased the E-selectin expression, an effect prevented by estradiol but not by progesterone treatment. Systemically, estradiol treatment increased the number of peripheral blood leukocytes in OVx allergic rats when compared to non treated-OVx allergic rats. Cultured-BAL cells of OVx allergic rats released elevated amounts of LTB4 and nitrites while bone marrow cells increased the release of TNF-α and nitrites. Estradiol treatment of OVx allergic rats was associated with a decreased release of TNF-α, IL-10, LTB4 and nitrites by bone marrow cells incubates. In contrast, estradiol caused an increase in IL-10 and NO release by cultured-BAL cells. Progesterone significantly increased TNF- α by cultured BAL cells and bone marrow cells.Conclusions: Data presented here suggest that upon hormonal oscillations the immune sensitization might trigger an allergic lung inflammation whose phenotype is under control of estradiol. Our data could contribute to the understanding of the protective role of estradiol in some cases of asthma symptoms in fertile ans post-menopausal women clinically observed. © 2010 de Oliveira et al; licensee BioMed Central Ltd.

Ejecución del programa de trabajo del Comité de Desarrollo y Cooperación del Caribe (CDCC) = Implementation of the work programme of the Caribbean Development and Co-operation Committee (CDCC)

Incluye Bibliografía

Ejecución del programa de trabajo del Comité de Desarrollo y Cooperación del Caribe (CDCC) = Implementation of the work programme of the Caribbean Development and Co-operation Committee (CDCC)

Incluye Bibliografía

Ejecución del programa de trabajo del CDCC: prioridades, programa de trabajo del CDCC, autoridad específica, endoso, apoyo y otras acciones solicitadas al CDCC con respecto al programa de trabajo del Secretariado = Implementation of the work programme of the CDCC: priorities, work programme of the CDCC, specific authority, endorsement, support and other action requested from CDCC in connection with the Secretariat's work programme

Presenta las actividades de cooperacion tecnica entre los paises en desarrollo, realizadas por el CDCC en lo que se refiere al campo de la informacion y a los sectores agricola, social, educacion, transporte y comunicaciones, comercio internacional y finanzas, energia y recursos naturales.

Reseña y perspectivas acerca del rol y programa de trabajo del Comité de Desarrollo y Cooperación del Caribe (CDCC) = Review and perspectives on the role and work programme of the Caribbean Development and Co-operation Committee (CDCC) = Revue et perspectives du rôle et du programme de travail du Comité de Développement et de Coopération des Caraïbes (CDCC)

Evalua y examina nuevas perspectivas en relacion al rol y programa de trabajo del CDCC.

Ejecución del programa de trabajo del Comité de Desarrollo y Cooperación del Caribe (CDCC) = Implementation of the work programme of the Caribbean Development and Co-operation Committee (CDCC) = Mise en oeuvre du programme de travail du Comité de Développement et de Coopération des Caraïbes (CDCC)

Informa de los avances logrados desde el octavo periodo de sesiones del CDCC en las areas de prioridad de cooperacion tecnica entre paises en desarrollo: informacion, ciencia y tecnologia, eliminacion de barreras idiomaticas, planificacion, sector agropecuario, sector social, educacion y cultura, transporte y comunicaciones, comercio, energia y recursos naturales.

Implementation of the work programme of the Caribbean Development and Co-operation Committee (CDCC) = Ejecución del programa de trabajo del Comité de Desarrollo y Cooperación del Caribe (CDCC) = Mise en oeuvre du programme de travail du Comité de Développement et de Cooperation des Caraïbes (CDCC)

Contiene un informe detallado de las actividades realizadas por la Secretaria del CDCC durante el periodo junio 1985-abril 1986.

Implementation of the work programme of the Caribbean Development and Co-operation Committee (CDCC)

Comprende las actividades realizadas por sectores, desde la novena sesion del CDCC, junio 1985 a septiembre 1987. Incluye una breve descripcion de las actividades no cumplidas, aplazadas o descontinuadas, como tambien las actividades propuestas para el proximo periodo.

Work programme of the ECLAC Subregional Headquarters for the Caribbean for the 1988-1989 biennium = Programa de trabajo de la Subsede Regional para el Caribe de la CEPAL para el bienio 1988-1989

Revisa el subprograma de trabajo de la Subsede Regional para el Caribe de la CEPAL para el bienio 1988-1989.