Sēfer Šēveṭ Yehûdā : wol fer ṭaiṭšṭ ... wundr berlichi gšichnis di gišehn zain unzrn elṭrn in den goles ...

[Šelōmō Ibn-Wirgā]

Sēfer Šēveṭ ham-mûsār : in loišn ha-koideš ... fun loišn ha-koideš in ṭaiṭš ...

welchś hoṭ meḥaber giwezn ... Elî hak-kôhēn miq-q"q Izmir ...

Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer.

BACKGROUND There is evidence that tumour-stroma interactions have a major role in the neoplastic progression of pancreatic ductal adenocarcinoma (PDAC). Tumour budding is thought to reflect the process of epithelial-mesenchymal transition (EMT); however, the relationship between tumour buds and EMT remains unclear. Here we characterize the tumour-budding- and stromal cells in PDAC at protein and mRNA levels concerning factors involved in EMT. METHODS mRNA in situ hybridisation and immunostaining for E-cadherin, β-catenin, SNAIL1, ZEB1, ZEB2, N-cadherin and TWIST1 were assessed in the main tumour, tumour buds and tumour stroma on multipunch tissue microarrays from 120 well-characterised PDACs and associated with the clinicopathological features, including peritumoural (PTB) and intratumoural (ITB) budding. RESULTS Tumour-budding cells showed increased levels of ZEB1 (P<0.0001) and ZEB2 (P=0.0119) and reduced E-cadherin and β-catenin (P<0.0001, each) compared with the main tumour. Loss of membranous β-catenin in the main tumour (P=0.0009) and tumour buds (P=0.0053), without nuclear translocation, as well as increased SNAIL1 in tumour and stromal cells (P=0.0002, each) correlated with high PTB. ZEB1 overexpression in the main tumour-budding and stromal cells was associated with high ITB (P=0.0084; 0.0250 and 0.0029, respectively) and high PTB (P=0.0005; 0.0392 and 0.0007, respectively). ZEB2 overexpression in stromal cells correlated with higher pT stage (P=0.03), lymphatic invasion (P=0.0172) and lymph node metastasis (P=0.0152). CONCLUSIONS In the tumour microenvironment of phenotypically aggressive PDAC, tumour-budding cells express EMT hallmarks at protein and mRNA levels underlining their EMT-type character and are surrounded by stromal cells expressing high levels of the E-cadherin repressors ZEB1, ZEB2 and SNAIL1, this being strongly associated with the tumour-budding phenotype. Moreover, our findings suggest the existence of subtypes of stromal cells in PDAC with phenotypical and functional heterogeneity.

Sēfer Šēveṭ mûsār : bi-lešôn aškenaz ... ; manin un froien ṭuṭ dś šini sefer an-šoien ... in ṭaiṭš

ḥibbērô Eliyyāhû hak-kōhēn ... mi- ... q"q Izmîr

Sēfer Šēveṭ mûsār : ... fun lošn ha-koideš in ṭaiṭš izṭ worn gbrachṭ ...

... welchś hoṭ meḥaber giwezn ... Eli hak-kohen mi-k"k Izmir

Sēfer ham-maggîd : mik-ketûvîm ašer lô hāyû kevār kaz-ze le-ʿôlāmîm ... û-ve-ôtiyyôt ḥadāšîm ...

Digitalisat der Ausg. Zultzbach, [1764/65]

Sēfer Šēveṭ Yehûdā : wol fer ṭaiṭšṭ gor kurtzlich ... fr gmeini bole-bosim mann un waibr ...

meḥaber Selomo Wirga

Ms. hebr. oct. 52 - Agadot ve-ḥidushim

Vorbesitzer: Moses Simon Sivitz

Ms. hebr. oct. 64 - Derushim ve-hespedim

Vorbesitzer: Abraham Merzbacher

Gender-Specific Associations between Circulating T-Cadherin and High Molecular Weight-Adiponectin in Patients with Stable Coronary Artery Disease.

Close relationships exist between presence of adiponectin (APN) within vascular tissue and expression of T-cadherin (T-cad) on vascular cells. APN and T-cad are also present in the circulation but here their relationships are unknown. This study investigates associations between circulating levels of high molecular weight APN (HMW-APN) and T-cad in a population comprising 66 women and 181 men with angiographically proven stable coronary artery disease (CAD). Plasma HMW-APN and T-cad were measured by ELISA and analysed for associations with baseline clinical characteristics and with each other. In multivariable analysis BMI and HDL were independently associated with HMW-APN in both genders, while diabetes and extent of coronary stenosis were independently associated with T-cad in males only. Regression analysis showed no significant association between HMW-APN and T-cad in the overall study population. However, there was a negative association between HMW-APN and T-cad (P=0.037) in a subgroup of young men (age <60 years, had no diabetes and no or 1-vessel CAD) which persisted after multivariable analysis with adjustment for all potentially influential variables (P=0.021). In the corresponding subgroup of women there was a positive association between HMW-APN and T-cad (P=0.013) which disappeared after adjustment for HDL. After exclusion of the young men, a positive association (P=0.008) between HMW-APN and T-cad was found for the remaining participants of the overall population which disappeared after adjustment for HDL and BMI. The existence of opposing correlations between circulating HMW-APN and T-cad in male and female patient populations underscores the necessity to consider gender as a confounding variable when evaluating biomarker potentials of APN and T-cad.

Des Herrn Oberrabbiner Rapoport Dibre schalom ve-emet [Rezension]

Samson Raphael Hirsch

Chesed ve-emet Wohlthätige Wahrheit : Ein Wort zur Beruhigung an die Mitglieder der deutsch-israelitischen Gemeinde in Hamburg, betreffend die rituelle Zulässigkeit des israelitischen Friedhofes zu Ohlsdorf, von Rabbiner R. Fink

Joseph Gugenheimer

Chesed ve-emet Wohlthätige Wahrheit : Ein Wort zur Beruhigung an die Mitglieder der deutsch-israelitischen Gemeinde in Hamburg, betreffend die rituelle Zulässigkeit des israelitischen Friedhofes zu Ohlsdorf, von Rabbiner R. Fink

Joseph Gugenheimer