492 resultados para Straßenbahn (Prag)


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Translation of Dĕjepis mĕsta Prahy.

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Mode of access: Internet.

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Accompanies "Eilfter [-zwölfter] Jahresbericht über das Deutsche Staats-Gymnasium in Prag-Altstadt für das Schuljahr 1882-83 [- 1883-84]"

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Mode of access: Internet.

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Has also Bohemian title-page: text in both Bohemian and German.

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Title varies slightly.

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Thesis (doctoral)--Friedrich Wilhelms Universitat zu Berlin.

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Coordination of apical constriction in epithelial sheets is a fundamental process during embryogenesis. Here, we show that DRhoGEF2 is a key regulator of apical pulsation and constriction of amnioserosal cells during Drosophila dorsal closure. Amnioserosal cells mutant for DRhoGEF2 exhibit a consistent decrease in amnioserosa pulsations whereas overexpression of DRhoGEF2 in this tissue leads to an increase in the contraction time of pulsations. We probed the physical properties of the amnioserosa to show that the average tension in DRhoGEF2 mutant cells is lower than wild-type and that overexpression of DRhoGEF2 results in a tissue that is more solid-like than wild-type. We also observe that in the DRhoGEF2 overexpressing cells there is a dramatic increase of apical actomyosin coalescence that can contribute to the generation of more contractile forces, leading to amnioserosal cells with smaller apical surface than wild-type. Conversely, in DRhoGEF2 mutants, the apical actomyosin coalescence is impaired. These results identify DRhoGEF2 as an upstream regulator of the actomyosin contractile machinery that drives amnioserosa cells pulsations and apical constriction.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)