Capecitabine and vinorelbine as first-line treatment in elderly patients (> or =65 years) with metastatic breast cancer. A phase II trial (SAKK 25/99)

BACKGROUND: We evaluated previously established regimens of capecitabine plus vinorelbine in older patients with advanced breast cancer stratified for presence versus absence of bone metastases. PATIENTS AND METHODS: Patients > or =65 years who had received no prior chemotherapy for advanced breast cancer received up to six 21-day cycles of vinorelbine 20 mg/m(2) i.v. on days 1 + 8 with oral capecitabine on days 1-14 (1,000 vs. 1,250 mg/m(2) daily in patients with vs. without bone involvement). RESULTS: Median age was 72 years in patients with bone metastases (n = 47) and 75 years in patients without bone metastases (n = 23). Response rates were 43% (95% confidence interval, CI, 28.3-58.8) and 57% (95% CI = 34.5-76.8), respectively. Median time to progression was 4.3 (95% CI = 3.5-6.0 months) and 7.0 months (CI = 4.1-8.3), respectively. Neutropenia was the most common toxicity, with grade 3/4 occurring in 43 and 39%, respectively. Pulmonary embolism was seen in 5 and grade 3 thrombosis in 3 patients. Other toxicities were mild to moderate. CONCLUSIONS: These regimens of capecitabine and vinorelbine are active and well tolerated in patients with advanced breast cancer > or =65 years. Response rates were comparable to published results. The lower capecitabine doses appeared appropriate given the advanced age, bone involvement and prior radiotherapy.

A critical history of the doctrine of a future life in Israel, in Judaism, and in Christianity or Hebrew, Jewish, and Christian eschatlology from pre-prophetic times till the close of the New Testament Canon, being the first Jowett lectures delivered in 1898-99

R. H. Charles

Ms. hebr. oct. 99 - [Sammelband in 4 Teilen: Handschriftenkonvolut]

Vorbesitzer: Eljāqīm Carmoly; Abraham Merzbacher

Ms. Barth. 99 - Theologische Sammelhandschrift

Vorbesitzer: Jungo Frosch; Bartholomaeusstift Frankfurt am Main

Denkschrift des patriotischen Vereins zu Berlin, betreffend die von der Zweiten Kammer ausgeführte Revision der Artikel 98, 99 und 108 der Verfassung vom 5. Dezember 1848

Boberach: Es muß verhindert werden, daß die Beschlüsse über das Budgetrecht so ausgelegt werden können, daß bei einem neuen Konflikt zwischen Krone und Parlament eine Steuerverweigerung möglich wird

Die Urwähler des 99. Wahlbezirks versammeln sich ... auf dem Wollboden, Zimmerstraße, in der goldenen Kugel: Das Recht des Volkes, seine Vertreter in der Kammer selber wählen zu dürfen ...

Welsch (Projektbearbeiter): Aufruf zu zahlreichem Erscheinen der Urwähler zur Vorversammlung

Rechenschafts-Bericht des Actions-Comités über seine Thätigkeit im Jahre 1898/99

Oskar Marmorek

Ms. germ. qu. 99 - Vita Jesu Christi in deutscher Bearbeitung

Vorbesitzer: T. O. Weigel; Victor Goldschmidt