Le règne animal distribué d'après son organisation, pour servir de base à l'histoire naturelle des animaux et d'introduction à l'anatomie comparée.

t.2 (1829)

Le règne animal distribué d'après son organisation, pour servir de base à l'histoire naturelle des animaux et d'introduction à l'anatomie comparée.

t.1 (1829)

Children, computer and creativity : usability guidelines for designing a game authoring tool for children

Magdeburg, Univ., Fak. für Informatik, Diss., 2009

Best-Practice - Mobile Testing Viewing mobile usability studies with the example of an eyetracking study in the retail sector

Today, usability testing in the development of software and systems is essential. A stationary usability lab offers many different possibilities in the evaluation of usability, but it reaches its limits in terms of flexibility and the experimental conditions. Mobile usability studies consider consciously outside influences, and these studies require a specially adapted approach to preparation, implementation and evaluation. Using the example of a mobile eye tracking study the difficulties and the opportunities of mobile testing are considered.

Usability-Methodik in der Technischen Dokumentation : Lernmaterial für Methoden der Usability zur Qualitätssicherung und nutzerzentrierten Entwicklung, mit Übungsaufgaben

[s.c.]

Konzeption einer Benutzerschnittstelle sowie Realisierung von Usability– und UI-Tests im Rahmen der prototypischen Entwicklung einer Android-App für eine Crowdtesting-Plattform

[s.c.]

Wa(h)re Lust - Sex Toys im Wandel der Zeit : mit besonderem Fokus auf die sexualpädagogische Praxis

[s.c.]

Re-evaluation of Syagrus loefgrenii Glassman and S. rachidii Glassman.

v.34:no.2(1971)

Annales de la science agronomique française et étrangère.

t. 2 1913

Révision des champignons, tant supérieurs qu'inférieurs trouvés jusqu'à ce jour dans les Pays-Bas / par C.A.J.A. Oudemans.

2

Révision des champignons, tant supérieurs qu'inférieurs trouvés jusqu'à ce jour dans les Pays-Bas / par C.A.J.A. Oudemans.

1

Annales de la science agronomique française et étrangère.

1, 1897

Epidermal growth factor receptor: a re-emerging target in glioblastoma.

PURPOSE OF REVIEW: Amplification and overexpression of the epidermal growth factor receptor (EGFR) gene are a hallmark of primary glioblastoma (45%), making it a prime target for therapy. In addition, these amplifications are frequently associated with oncogenic mutations in the extracellular domain. However, efforts at targeting the EGFR tyrosine kinase using small molecule inhibitors or antibodies have shown disappointing efficacy in clinical trials for newly diagnosed or recurrent glioblastoma. Here, we review recent insights into molecular mechanisms relevant for effective targeting of the EGFR pathway. RECENT FINDINGS: Molecular workup of glioblastoma tissue of patients under treatment with small molecule inhibitors has established drug concentrations in the tumor tissue, and has shed light on the effectiveness of target inhibition and respective effects on pathway signaling. Further, functional analyses of interaction of small molecule inhibitors with distinct properties to bind to the active or inactive form of EGFR have provided new insights that will impact the choice of drugs. Finally, vaccination approaches targeting the EGFRvIII mutant featuring a tumor-specific antigen have shown promising results that warrant larger controlled clinical trials. SUMMARY: A combination of preclinical and clinical studies at the molecular level has provided new insights that will allow refining strategies for targeting the EGFR pathway in glioblastoma.