4 '-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Profile of Maytenus aquifolium action over free radicals and reactive oxygen species

Reactive oxygen species (ROS) and free radical species have been implicated in initiating, accompanying or causing many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Maytenus species have long been used, in several countries, as traditional medicines against gastric ulcers, dyspepsia and others gastric problems and for their anti-inflammatory properties. In this study, Maytenus aquifolium (Celastraceae) root bark ethanol extract was assessed for its ability to scavenge free radicals and reactive oxygen species. The results were expressed as percentage inhibition of the active species. The extract was efficient against studied reactive species: DPPH radical (obtained inhibition = 35.5 ± 1.3 %), ABTS.+ (IC50 = 0.0036 ± 0.0003 mg/mL), HOCl (IC50 = 0.002 ± 0.0001 mg/mL), O2 .- (obtained inhibition = 36.0 ± 2.1 %), and NO. (obtained inhibition = 18.3 ± 0.4 %). Uniterms Oxidant species Free radicals Maytenus aquifolium Oxidative damage.

La contaminación de los ríos y sus efectos en las áreas costeras y el mar

Incluye Bibliografía

Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage

Baccharis dracunculifolia DC (Asteraceae) is the main botanical source used by honeybees to produce Brazilian green propolis whose hepatoprotective properties have been already described. In this work we investigated the protective effects of the glycolic extract of B. dracunculifolia (GEBd) against oxidative stress in isolated rat liver mitochondria (RLM). The GEBd was prepared by fractionated percolation using propylene glycol as solvent. The total phenols and flavonoids, which are substances with recognized antioxidant action, were quantified in GEBd and the phytochemical analysis was carried out by HPLC. GEBd exhibited significant scavenger activity towards DPPH radicals and superoxide anions in a concentration-dependent manner, and also a Fe 2+ chelating activity. GEBd decreased the basal H 2O 2 generation and the Fe 2+- or t-BuOOH-induced ROS production in isolated mitochondria. Lipid oxidation of mitochondrial membranes, protein thiol groups and GSH oxidation were also prevented by GEBd. This shows that B. dracunculifolia exhibit potent antioxidant activity protecting liver mitochondria against oxidative damage and such action probably contribute to the antioxidant and hepatoprotective effects of green propolis. © 2011 Elsevier Ltd.

Aprovechamiento de ríos y lagos: proyecto de resolución aprobado por el Comité II el 25 de mayo de 1957

Incluye Bibliografía

Antecedentes para el estudio de prefactibilidad acerca de la contaminación de la refinería de Esmeraldas en los ríos Teaone y Esmeraldas

Incluye Bibliografía

Informe del Seminario-Taller sobre el Análisis de la Contaminación de la Refinería Estatal Esmeraldas en los Ríos Esmeraldas y Teaone = Report of the Seminar-Workshop on the Analysis of the Pollution from the Esmeraldas State Refinery in the Esmeraldas and Teaone Rivers

Incluye Bibliografía

Estudio económico sobre el impacto ambiental de la contaminación hídrica de la refinería de Esmeraldas en los Ríos Teaone y Esmeraldas

Incluye Bibliografía

Estudio económico sobre el impacto ambiental de la contaminación hídrica de la Refinería de Esmeraldas en los ríos Teaone y Esmeraldas

Incluye Bibliografía

Análisis de la contaminación producida por la Refinería Estatal Esmeraldas en los ríos Teaone y Esmeraldas

Incluye Bibliografía

Necesidades de información para la vigilancia y control de la contaminación en los ríos Esmeraldas y Teaone

Propuesta preliminar para explorar y estructurar el sistema de informática que resulta necesario para llevar a cabo las tareas de vigilancia y control de la calidad del agua en las cuencas de los ríos Esmeraldas y Teaone.

Informe del seminario-taller sobre el análisis de la contaminación de la Refinería Estatal Esmeraldas en los ríos Esmeraldas y Teaone

Incluye Bibliografía