971 resultados para Pro-Wrestling
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Käsittelee Korkeimman hallinto-oikeuden ratkaisua KHO:2007:77
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Aplicación móvil de apoyo al seguimiento del rendimiento académico de los estudiantes del campus universitario ITFIP, Institución de Educación Superior Colombiana
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Solució mòbil (Android) aplicada al campus universitari del ITFIP (Universidad Colombiana) com a eina de suport per al seguiment del rendiment acadèmic d'estudiants com a estratègia per reduir els nivells de deserció.
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Under pathological conditions, microglia, the resident CNS immune cells, become reactive and release pro-inflammatory cytokines and neurotoxic factors. We investigated whether this phenotypic switch includes changes in the expression of the L-type voltage-gated calcium channel (VGCC) in a rat model of N-methyl-d-aspartate-induced hippocampal neurodegeneration. Double immunohistochemistry and confocal microscopy evidenced that activated microglia express the L-type VGCC. We then analyzed whether BV2 microglia express functional L-type VGCC, and investigated the latter's role in microglial cytokine release and phagocytic capacity. Activated BV2 microglia express the CaV1.2 and CaV1.3 subunits of the L-type VGCC determined by reverse transcription-polymerase chain reaction, Western blot and immunocytochemistry. Depolarization with KCl induced a Ca2+ entry facilitated by Bay k8644 and partially blocked with nifedipine, which also reduced TNF-α and NO release by 40%. However, no nifedipine effect on BV2 microglia viability or phagocytic capacity was observed. Our results suggest that in CNS inflammatory processes, the L-type VGCC plays a specific role in the control of microglial secretory activity.
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Painovuosi nimekkeestä.
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Arkit: A-B4.
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Arkit: A-C4.
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Arkit: A-C4 D2.
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Arkit: A-C4.
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Painovuosi nimekkeestä.
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Arkit: 1 arkintunnukseton lehti, A-B4 C3.
