A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs and the antidiabetic effects of the glitazone drugs in humans are due to activation of the α (NR1C1) and γ (NR1C3) subtypes, respectively. By contrast, the therapeutic potential of the δ (NR1C2) subtype is unknown, due in part to the lack of selective ligands. We have used combinatorial chemistry and structure-based drug design to develop a potent and subtype-selective PPARδ agonist, GW501516. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux. When dosed to insulin-resistant middle-aged obese rhesus monkeys, GW501516 causes a dramatic dose-dependent rise in serum high density lipoprotein cholesterol while lowering the levels of small-dense low density lipoprotein, fasting triglycerides, and fasting insulin. Our results suggest that PPARδ agonists may be effective drugs to increase reverse cholesterol transport and decrease cardiovascular disease associated with the metabolic syndrome X.

"A list of books borrowed from the former Library & not yet return'd," ca. 1764

Lists books borrowed by many individuals, including Governor William Shirley, Colonel Brinley, General Brattle, Secretary Willard, Judge Danforth, Colonel Wendell, Thomas Oliver, Christ Bridge Marsh, and Francis Foxcroft. Entries include the author and title of the borrowed volumes.

List of books bequeathed by Governor William Dummer and donated by Dr. Sewall, with list of some books saved from fire because checked out, undated

The list of books "sav'd by being borrowed when the Library was burn'd" is organized according to borrower.

Letter book : manuscript, 1764-1771

Tryon's official letter book containing copies of letters and documents relating to his work as colonial governor of North Carolina; with references concerning drawing a boundary between North Carolina and South Carolina; talks with the Cherokee Indians; the establishment of a postal service; working with the Propagation of the Gospels in Foreign Parts; establishing the Church of England in North Carolina; strengthening the defenses of the colony; maintaining better communication with Great Britain; and other events.

Letters from William Tudor to his family,

Four letters written from St. Pierre, Martinique, Basseterre, Guadalupe, and St. Barts. In one letter written over a number of days, he describes extensively his travels in Antigua, and the various people he met, including Captain William Jarvis. He also details his meeting with Ralph Payne, 1st Baron Lavington, the governor of the Leeward Islands, regarding the prospects of importing ice.

Letters from Daniel Bates to William Jenks, May 1795-September 1798

Daniel Bates wrote these five letters to his friend and classmate, William Jenks, between May 1795 and September 1798. In a letter written May 12, 1795, Bates informs Jenks, who was then employed as an usher at Mr. Webb's school, of his studies of Euclid, the meeting of several undergraduate societies, and various sightings of birds, gardens and trees. In a letter written in November 1795 from Princeton, where he was apparently on vacation with the family of classmate Leonard Jarvis, he describes playing the game "break the Pope's neck" and tells Jenks what he was reading (Nicholson, Paley?, and Thompson) and what his friend's father was reading (Mirabeau and Neckar).

Account books of William Aspinwall, 1776-1812 (inclusive)

Two account books containing entries noting patients visited, fees charged, and small accounts of Dr. William Aspinwall (1743-1823) in Boston and Brookline, Massachusetts, from 1776 to 1812. He includes sections for "Women's Accounts" with charges generally rendered to their husbands or other male relatives. There is also an entry charging the town of Cambridge, Massachusetts, four dollars and fifty cents for medicines and attendance to a boy who contracted smallpox.

Medieval India under Mohammedan rule (A.D. 712-1764).

Mode of access: Internet.

Little journeys to the homes of great physicians : William Beaumont - physiologist ; Augustus Charles Bernays - surgeon ; Williams McKim Marriott - pediatrician /

Mode of access: Internet.

The complete poetical works of William Wordsworth, poet laureate, etc. etc. /

Mode of access: Internet.

The works of William Hogarth : with descriptions and explanations /

Mode of access: Internet.

The life of Francis, lord Bacon, baron of Verulam, viscount St. Albans, and lord high chancellor of England.

Manuscript index (4 p.) signed: William Greig, appended to L. C. copy.

The history of England, from the first invasion by the Romans to the accession of William and Mary in 1688.

Mode of access: Internet.