4-year clinical outcomes and predictors of repeat revascularization in patients treated with new-generation drug-eluting stents: a report from the RESOLUTE All-Comers trial (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention)

OBJECTIVES The aim of the study was to investigate 4-year outcomes and predictors of repeat revascularization in patients treated with the Resolute zotarolimus-eluting stent (R-ZES) (Medtronic, Minneapolis, Minnesota) and XIENCE V everolimus-eluting stent (EES) (Abbott Vascular, Abbott Park, Illinois) in the RESOLUTE (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention) All-Comers trial. BACKGROUND Data on long-term outcomes of new-generation drug-eluting stents are limited, and predictors of repeat revascularization due to restenosis and/or progression of disease are largely unknown. METHODS Patients were randomly assigned to treatment with the R-ZES (n = 1,140) or the EES (n = 1,152). We assessed pre-specified safety and efficacy outcomes at 4 years including target lesion failure and stent thrombosis. Predictors of revascularization at 4 years were identified by Cox regression analysis. RESULTS At 4 years, the rates of target lesion failure (15.2% vs. 14.6%, p = 0.68), cardiac death (5.4% vs. 4.7%, p = 0.44), and target vessel myocardial infarction (5.3% vs. 5.4%, p = 1.00), clinically-indicated target lesion revascularization (TLR) (7.0% vs. 6.5%, p = 0.62), and definite/probable stent thrombosis (2.3% vs. 1.6%, p = 0.23) were similar with the R-ZES and EES. Independent predictors of TLR were age, insulin-treated diabetes, SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) score, treatment of saphenous vein grafts, ostial lesions, and in-stent restenosis. Independent predictors of any revascularization were age, diabetes, previous percutaneous coronary intervention, absence of ST-segment elevation myocardial infarction, smaller reference vessel diameter, SYNTAX score, and treatment of left anterior descending, right coronary artery, saphenous vein grafts, ostial lesions, or in-stent restenosis. CONCLUSIONS R-ZES and EES demonstrated similar safety and efficacy throughout 4 years. TLR represented less than one-half of all repeat revascularization procedures. Patient- and lesion-related factors predicting the risk of TLR and any revascularization showed considerable overlap. (A Randomized Comparison of a Zotarolimus-Eluting Stent With an Everolimus-Eluting Stent for Percutaneous Coronary Intervention [RESOLUTE-AC]; NCT00617084).

Das Wiener Ghetto : seine Häuser und seine Bewohner. 1. das Judenviertel in der inneren Stadt bis zu seiner Aufhebung im Jahre 1421... 2. die Judenstadt im unteren Werd. 1625 - 1670. Mit 2 Pl. u. Textabb.

im Auftr. d. Hist. Komm. d. israelit. Kultusgemeinde in Wien bearb. von Ignaz Schwarz

Geschichte der Juden in Wien bis zum Jahre 1625

von Ignaz Schwarz

Geschichte der Juden in Wien : 1625 - 1740

von Max Grunwald

Die letzte Vertreibung der Juden aus Wien und Niederösterreich, ihre Vorgeschichte <1625 - 1670> und ihre Opfer

von David Kaufmann

Vegetation and fire history of coastal north-eastern Sardinia (Italy) under changing Holocene climates and land use

Little is known about the vegetation and fire history of Sardinia, and especially the long-term history of the thermo-Mediterranean belt that encompasses its entire coastal lowlands. A new sedimentary record from a coastal lake based on pollen, spores, macrofossils and microscopic charcoal analysis is used to reconstruct the vegetation and fire history in north-eastern Sardinia. During the mid-Holocene (c. 8,100–5,300 cal bp), the vegetation around Stagno di Sa Curcurica was characterised by dense Erica scoparia and E. arborea stands, which were favoured by high fire activity. Fire incidence declined and evergreen broadleaved forests of Quercus ilex expanded at the beginning of the late Holocene. We relate the observed vegetation and fire dynamics to climatic change, specifically moister and cooler summers and drier and milder winters after 5,300 cal bp. Agricultural activities occurred since the Neolithic and intensified after c. 7,000 cal bp. Around 2,750 cal bp, a further decline of fire incidence and Erica communities occurred, while Quercus ilex expanded and open-land communities became more abundant. This vegetation shift coincided with the historically documented beginning of Phoenician period, which was followed by Punic and Roman civilizations in Sardinia. The vegetational change at around 2,750 cal bp was possibly advantaged by a further shift to moister and cooler summers and drier and milder winters. Triggers for climate changes at 5,300 and 2,750 cal bp may have been gradual, orbitally-induced changes in summer and winter insolation, as well as centennial-scale atmospheric reorganizations. Open evergreen broadleaved forests persisted until the twentieth century, when they were partly substituted by widespread artificial pine plantations. Our results imply that highly flammable Erica vegetation, as reconstructed for the mid-Holocene, could re-emerge as a dominant vegetation type due to increasing drought and fire, as anticipated under global change conditions.

Bären und Levitenkanne auf dem Grabsteine Issachar Bermanns (1661-1736) in Halberstadt [Illustration]

Scan von Monochrom-Mikroform

Druckerzeichen aus: Machsor Deutscher und polnischer Ritus [Illustration] : Prag 1661/1662 - Gedruckt von Jehuda ben Jaakob Bak

Scan von Monochrom-Mikroform

Pensées de M. Pascal sur la religion, et sur quelques autres sujets : qui ont esté trouvées aprés sa mort parmy ses papiers

Vorlageform des Erscheinungsvermerks: A AMSTERDAM, Chez ABRAHAM WOLFGANG, M DC LXXXIV.

Abbildung, Eines erschrecklichen Meer-Wunders : So am Ende des 1661. Jahrs in Holland zwischen Schevelingen und Catwick auff-See gefangen worden

Bibliogr. Nachweis: Faust: Zoolog. Einblattdrucke .̤ I,13

Diese Figur ist in der größ vnd Höhe dreyviertel ein in einem Dorff bey Franckenthal Marsch genādt an einem Baum also auß der Erden gewachsen : funden 8, 18. February, auch vielen Herrschafften Communicirt vnd ist inen̄ Holl also gestalt gewessen Anno 1625

Bibliograph. Nachweis: Harms I,224

Abbildung Eines erschrecklichen Meer-Wunders : So am Ende des 1661. Jahrs in Holland zwischen Schevelingen und Catwick auff-See gefangen worden

Bibliogr. Nachweis: Faust: Zoolog. Einblattdrucke .̤ I,12

Vorstellung der scharpffen Execution, wie selbige an 6 Malefitz Personen in der Fürstlichen Statt Wohlau, den 27. April, vnd II July deß 1661. Jahrs, vollzogen worden : Von ihrem abscheulichen Verbrechen, meldet der Text weitläufftig

Original: Text fehlt. Risse u. kleinere Fehlstellen im Kupferstich