List of Bid Proposal Holders, May 20, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, June 17, 2014

List of Bid Proposal Holders

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. However, these therapies are effective only in a subset of patients. Activating mutations in the KRAS gene are found in 30-40% of colorectal tumors and are associated with poor response to anti-EGFR therapies. Thus, KRAS mutation status can predict which patient may or may not benefit from anti-EGFR therapy. Although many diagnostic tools have been developed for KRAS mutation analysis, validated methods and standardized testing procedures are lacking. This poses a challenge for the optimal use of anti-EGFR therapies in the management of colorectal carcinoma. Here we review the molecular basis of EGFR-targeted therapies and the resistance to treatment conferred by KRAS mutations. We also present guideline recommendations and a proposal for a European quality assurance program to help ensure accuracy and proficiency in KRAS mutation testing across the European Union.

List of Bid Proposal Holders, July 15, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, August 16, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, October 21, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, September 16, 2014

List of Bid Proposal Holders

What's so special about conversion disorder? A problem and a proposal for diagnostic classification.

Conversion disorder presents a problem for the revisions of DSM-IV and ICD-10, for reasons that are informative about the difficulties of psychiatric classification more generally. Giving up criteria based on psychological aetiology may be a painful sacrifice but it is still the right thing to do.

List of Bid Proposal Holders, November 18, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, December 16, 2014

List of Bid Proposal Holders

List of Bid Proposal Holders, January 21, 2015

List of Bid Proposal Holders

Dénervation rénale pour le traitement de l'hypertension artérielle résistante: proposition pour une attitude multidisciplinaire commune [Renal denervation in resistant hypertension: proposal for a common multidisciplinary attitude].

The prevalence of resistant hypertension ranges between 5-30%. Patients with resistant hypertension are at increased risk of cardiovascular events. Radiofrequency renal denervation is a recent and promising technique that can be used in the setting of resistant hypertension. However, long-term safety and efficacy data are lacking and evidence to use this procedure outside the strict setting of resistant hypertension is missing. The aim of the article is to propose a common work-up for nephrologists, hypertensiologists, cardiologists and interventional radiologists in order to avoid inappropriate selection of patients and a possible misuse of this procedure.

List of Bid Proposal Holders, February 17, 2015

List of Bid Proposal Holders

List of Bid Proposal Holders, March 12, 2015

List of Bid Proposal Holders