Annales de la jeunesse catholique : organe de l'Association catholique de la jeunesse française

1905/03/01 (SER3,A20,N4).

Annales de la jeunesse catholique : organe de l'Association catholique de la jeunesse française

1905/03/01 (A20,SER3,N4).

The hpx genetic system for hypoxanthine assimilation as a nitrogen source in Klebsiella pneumoniae: gene organization and transcriptional regulation.

Growth experiments showed that adenine and hypoxanthine can be used as nitrogen sources by several strains of K. pneumoniae under aerobic conditions. The assimilation of all nitrogens from these purines indicates that the catabolic pathway is complete and proceeds past allantoin. Here we identify the genetic system responsible for the oxidation of hypoxanthine to allantoin in K. pneumoniae. The hpx cluster consists of seven genes, for which an organization in four transcriptional units, hpxDE, hpxR, hpxO and hpxPQT, is proposed. The proteins involved in the oxidation of hypoxanthine (HpxDE) or uric acid (HpxO) did not display any similarity to other reported enzymes known to catalyze these reactions, but instead are similar to oxygenases acting on aromatic compounds. Expression of the hpx system is activated by nitrogen limitation and by the presence of specific substrates, with hpxDE and hpxPQT controlled by both signals. Nitrogen control of hpxPQT transcription, which depends on 54, is mediated by the Ntr system. In contrast, neither NtrC nor NAC is involved in the nitrogen control of hpxDE, which is dependent on 70 for transcription. Activation of these operons by the specific substrates is also mediated by different effectors and regulatory proteins. Induction of hpxPQT requires uric acid formation, whereas expression of hpxDE is induced by the presence of hypoxanthine through the regulatory protein HpxR. This LysR-type regulator binds to a TCTGC-N4-GCAAA site in the intergenic hpxD-hpxR region. When bound to this site for hpxDE activation, HpxR negatively controls its own transcription.

L'Anti-clérical : ["puis" organe spécial des groupes de la Ligue anticléricale]

Périodicité : Hebdomadaire ; semi hebdomadaire ; mensuel

L'Anti-clérical : ["puis" organe spécial des groupes de la Ligue anticléricale]

1879/06 (A1,N4)-1879/10 (A1,N21). Contient : SUPP N7.

Archives de philosophie du droit et de sociologie juridique

1937 (A7,N3)- (A7,N4).

Archives de philosophie du droit et de sociologie juridique

1938 (A8,N3)- (A8,N4).

Archives de philosophie du droit et de sociologie juridique

1935 (A5,N3)- (A5,N4).

La Bastille : journal antimaçonnique / dir. Copin-Albancelli ; dir. Louis Dasté

1902/12/20 (N4).

CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation.

NlmCategory="UNASSIGNED">Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a discovery sample of SOT recipients (n1=197). Positive results were tested for replication in two samples from the Swiss Transplant Cohort Study (STCS, n2=1294 and n3=759). Obesity and other metabolic traits were also tested. Associations with metabolic traits in population-based samples (n4=46'186, n5=123'865, n6>100,000) were finally analyzed. In the discovery sample, CRTC2 rs8450-AA genotype was associated with NODAT, fasting blood glucose and body mass index (Pcorrected<0.05). CRTC2 rs8450-AA genotype was associated with NODAT in the second STCS replication sample (odd ratio (OR)=2.01, P=0.04). In the combined STCS replication samples, the effect of rs8450-AA genotype on NODAT was observed in patients having received SOT from a deceased donor and treated with tacrolimus (n=395, OR=2.08, P=0.02) and in non-kidney transplant recipients (OR=2.09, P=0.02). Moreover, rs8450-AA genotype was associated with overweight or obesity (n=1215, OR=1.56, P=0.02), new-onset hyperlipidemia (n=1007, OR=1.76, P=0.007), and lower high-density lipoprotein-cholesterol (n=1214, β=-0.08, P=0.001). In the population-based samples, a proxy of rs8450G>A was significantly associated with several metabolic abnormalities. CRTC2 rs8450G>A appears to have an important role in the high prevalence of metabolic traits observed in patients with SOT. A weak association with metabolic traits was also observed in the population-based samples.The Pharmacogenomics Journal advance online publication, 8 December 2015; doi:10.1038/tpj.2015.82.

Bibliographie catholique : revue critique des ouvrages de religion, de philosophie, d'histoire, de littérature, d'éducation...

1847/10 (A7,N4).

Bibliographie catholique : revue critique des ouvrages de religion, de philosophie, d'histoire, de littérature, d'éducation...

1844/10 (A4,N4).

Bibliographie catholique : revue critique des ouvrages de religion, de philosophie, d'histoire, de littérature, d'éducation...

1847/11 (A7,N4).

Le Bloc républicain du Gâtinais : organe des partis radical-socialiste et socialiste ["puis" organe des radicaux, radicaux-socialistes et socialistes], paraissant le samedi

1906/04/07 (A1,N4).