Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a "binding-site barrier" phenomenon, can be seen in guinea pig micrometastases as small as 300 microns in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity.

Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.

Homozygous deletions have been central to the discovery of several tumor-suppressor genes, but their finding has often been either serendipitous or the result of a directed search. A recently described technique [Lisitsyn, N., Lisitsyn, N. & Wigler, M. (1993) Science 259, 946-951] held out the potential to efficiently discover such events in an unbiased manner. Here we present the application of the representational difference analysis (RDA) to the study of cancer. We cloned two DNA fragments that identified a homozygous deletion in a human pancreatic adenocarcinoma, mapping to a 1-centimorgan region at chromosome 13q12.3 flanked by the markers D13S171 and D13S260. Interestingly, this lies within the 6-centimorgan region recently identified as the BRCA2 locus of heritable breast cancer susceptibility. This suggests that the same gene may be involved in multiple tumor types and that its function is that of a tumor suppressor rather than that of a dominant oncogene.

Global database of surface ocean particulate organic carbon export fluxes diagnosed from the 234Th technique

Through the processes of the biological pump, carbon is exported to the deep ocean in the form of dissolved and particulate organic matter. There are several ways by which downward export fluxes can be estimated. The great attraction of the 234Th technique is that its fundamental operation allows a downward flux rate to be determined from a single water column profile of thorium coupled to an estimate of POC/234Th ratio in sinking matter. We present a database of 723 estimates of organic carbon export from the surface ocean derived from the 234Th technique. Data were collected from tables in papers published between 1985 and 2013 only. We also present sampling dates, publication dates and sampling areas. Most of the open ocean Longhurst provinces are represented by several measurements. However, the Western Pacific, the Atlantic Arctic, South Pacific and the South Indian Ocean are not well represented. There is a variety of integration depths ranging from surface to 220m. Globally the fluxes ranged from -22 to 125 mmol of C/m**2/d. We believe that this database is important for providing new global estimate of the magnitude of the biological carbon pump.

Lovieta Wilkinson (?) U-M Field Hockey, 1996 CMU

[might be Meredith Weinstein, #12]

University of Michigan Field Hockey Team, 1994

Back Row: Amy Helber, Jamie Robbins, Brie Derr, Julie Flachs, Asleya Koreishi, Meredith Weinstein, Sandra Cabrera, Nancy Irvine, Rachel Geisthardt

Front Row: Michelle Smulders, Meredith Franden, Selna Harris, Aimee Remigo, Jennifer Lupinski, Sherene Smith, Carolyn Schwarz, Gia Biagi, Brenda Beaudry

Mental health issues in grief counseling : summary of proceedings : National Conference on Mental Health Issues Related to Sudden Infant Death Syndrome, February 23-25, 1977, Friendship International Hotel, Baltimore, Md. /

Includes bibliographical references.

National Child Safety Seat Distribution Program evaluation.

National Highway Traffic Safety Administration, Washington, D.C.

Development and field test of a responsible alcohol service program. Volume II: server education program materials. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Dor reviʻi, beur ʻal masekhet Ḥulin.

Mode of access: Internet.

The Baltimore oriole, and A biographical sketch of Audubon,

"Authorities": p.55.

Die erdströme im deutschen reichstelegraphengebiet und ihr zusammenhang mit den erdmagnetischen erscheinungen : im auftrage des Reichspostamtes und des lektrotechnischen vereins sowie mit unterstützung seitens der Königl. preussischen akademie der wissenschaften /

Mode of access: Internet.

The Confederate raider Alabama;

Mode of access: Internet.

University of Michigan Field Hockey Team, 1995

Back Row: Carolyn Schwartz?. Julie Flachs, Gia Biagi, Jennifer Lupinski, Meredith Franden, Sherene Smith, Selina Harris, Erika Lorenson, Bree Derr, Michelle Schmulders

Middle Row: Meredith Weinstein, Aaleya Koreishi, Jamie Robbins?, Loveita Wilkinson, Lindsay Babbitt

Front Row: Amy Helber, Rachael Geisthardt

Missing: Ann Remigio, Amy Philbrook

University of Michigan Field Hockey Team, 1997

Top Row (left to right in line): Julie Flachs, Jeanne Shin, Ashley Thomas, Ashley Reichenbach, (18) Kati Oates, Courtney Reid, Lindsay Babbitt, (24) Aimee Remigio, Erica Widder, (5) Amy Philbrook, (38) Amy Helber, (22) Sandra Cabrera, (8) Regan Wolfsberg, (69) Erika Lorensond, (12), Meredith Weinstein, (21) Shelley Johnson

Left Corner: (3) Kelli Gannon, Jocelyn LaFace, (4) Tamra Geryk

Right Corner: (13) Loveita Wilkinson, (19) Sasha Dunlop

Board of Director and Officer of the Student Athletic Association, 1897-98

Back Row: Robert Danforth, Frank S. Simons, Forris D. Stevens, Albert H. Keith (baseball mngr), Harry Helfman (recoding secretary)

Middle Row: Harry L. Weinstein (treasurer), Carl M. Green, J.Deforest Richards (President), Albert Stevens, A.L.C. Atkinson

Front Row: Harry S. Vernon, Harrison Smalley, Harry T. Heald (ass't football mngr.)

Missing: Charles Tryon (vice president), Harry Potter (financial secretary), Ward Hughes (foootball mngr.), Allan Campbell (track mngr.), Walter Herrick (track mngr.), Harold Emmons, ass't football mngr.)