A study of drivers in major accidents, September, 1935-April, 1936, by Harold L. Gaunt [and] Laurence W. Murray, 1936

This preliminary study of the drivers involved in major accidents in Iowa and their subsequent examination was undertaken by the State Planning Board. All personal injury and fatal accidents, and those property damage accidents of such serious nature as to indicate the suspension or revocation of the drivers license, occurring in the state from 1935 to April 1036 are included.

The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease

Rare mutations in AßPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether common genetic variation in these genes confer risk to the common form of AD which occurs later in life (>65 years). We therefore tested single-nucleotide polymorphisms at these loci for association with late-onset AD (LOAD) in a large case-control sample consisting of 3,940 cases and 13,373 controls. Single-marker analysis did not identify any variants that reached genome-wide significance, a result which is supported by other recent genome-wide association studies. However, we did observe a significant association at the MAPT locus using a gene-wide approach (p = 0.009). We also observed suggestive association between AD and the marker rs9468, which defines the H1 haplotype, an extended haplotype that spans the MAPT gene and has previously been implicated in other neurodegenerative disorders including Parkinson's disease, progressive supranuclear palsy, and corticobasal degeneration. In summary common variants at AßPP, PSEN1, and PSEN2 and MAPT are unlikely to make strong contributions to susceptibility for LOAD. However, the gene-wide effect observed at MAPT indicates a possible contribution to disease risk which requires further study.

Defining the role of common variation in the genomic and biological architecture of adult human height

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

Bradley Institute of Music fonds

1.23 m. textual records, 1 col. post card, 1 b&w post card, 116 col. photographs, 59 b&w photographs, 6 negatives, 1 metal logo, 2 photo cuts, 7 woodcuts, 1 VHS tape, 1 stamp/press, 1 guest book, 5 account books

Self-organized sociopolitical interactions as the best way to achieve organized patterns in human social systems: going beyond the top-down control of classical political regimes

La monografía presenta la auto-organización sociopolítica como la mejor manera de lograr patrones organizados en los sistemas sociales humanos, dada su naturaleza compleja y la imposibilidad de las tareas computacionales de los regímenes políticos clásico, debido a que operan con control jerárquico, el cual ha demostrado no ser óptimo en la producción de orden en los sistemas sociales humanos. En la monografía se extrapola la teoría de la auto-organización en los sistemas biológicos a las din��micas sociopolíticas humanas, buscando maneras óptimas de organizarlas, y se afirma que redes complejas an��rquicas son la estructura emergente de la auto-organización sociopolítica.

MÍDIAS SOCIAIS DIGITAIS: ESPAÇO DE RELACIONAMENTO E COMUNICAÇÃO ESTRATÉGICA

O trabalho tem como proposta avaliar a postura das organizações nas mídias sociais digitais, considerando o fato de que esses novos ambientes virtuais têm modificado drasticamente a maneira pela qual elas promovem o relacionamento com seus públicos estratégicos. O objetivo principal da pesquisa é identificar e compreender como as organizações se posicionam diante de comentários desfavoráveis nas mídias sociais digitais que possam impactar sua imagem e reputação, bem como mostrar a importância de monitorar constantemente o consumidor e dialogar com ele nos canais digitais para evitar riscos à marca. A metodologia aplicada denomina-se Estudo de Casos Múltiplos, por meio da qual analisaram-se os comentários desfavoráveis às marcas: Vivo, Tim e Oi, na página do Facebook, durante o mês de setembro de 2015. Construiu-se um protocolo de pesquisa, e realizou-se o acompanhamento dessas marcas analisando-lhes os posts e os comentários desfavoráveis coletados no período. Constatou-se, após tais procedimentos que as operadoras apresentam frequentemente dificuldades para se relacionar com os públicos nas mídias sociais digitais, o que as coloca em risco quanto à sua imagem e reputação.

Catharine Waugh McCullouch papers in the Mary Earhart Dillon collection, 1869-1945

Collection primarily documents McCulloch's research on women's legal status, and her work with the Illinois Equal Suffrage Association, the National American Woman Suffrage Association, and the League of Women Voters. There is also documentation of women in the legal profession, of McCulloch's friendships with the other women suffragists and lawyers, and some biographical material. The papers contain little information about her family or social life.

University of Michigan Football Team, 1901

Top Row: Wesley Winkler, Ralph Drake, Charles Rothschild, Norman Sterry, Kenneth Robinson, Alfred Chadwick, Weldon Fix, Ross Kidston, Les Barkenbus, Harrison Weeks, David Dunlap, George Gregory, Harold Baker, Cecil Gooding, George Sadler

Third Row: student mngr. H.C. Crafts, Edward Dickey(?), David Beardsley, William Snushall, ? Smith, George Davison, Kennedy Potter, ? Clark, Charles Van Valkenberg, Neil Snow, Joseph Horgan, James Forrest, William Foote, Webb Sadler, ? Hayes

Second Row: trainer Keene Fitzpatrick, ? Smith, Samuel Sackett, Everett Sweeley, Herbert Graver, Walter Shaw, Hugh White, Albert Herrnstein, Curtis Redden, Dan McGugin, Ebin Wilson, Bruce Shorts, Arthur Redner, Temple Owens

Front Row: Ralph Husson, Albert Preussman, Arthur Urquhart, Willie Heston, Benjamin Southworth, coach Fielding Yost, Charles Crane, Jerome (mascot), John Lewis, Frank Doty, Frank Belknap

University of Michigan Football Team, 1902

Back row-standing: Keene Fitzpatrick, Joe Maddock, Coach Fielding Yost, Dan McGugin, Eugene Tefler, Frank Doty, Rolla Bigelow, Lorin(?) Jones, Andrews, Andrews, Samuel Sackett, DeStelle DeLappe, Anderson, William Snushall, Elmer Shank, Brown, William Cole, Clarence Wilcox, Shirk, Lake, James Turner, Kennedy Potter, George Read, Richardson, Ralph Drake, John Hincks, Clifford Kennedy

Middle Row-kneeling: Chauncey Brewer, John H. James, David Smith, Abner Howell, James Forrest, William Palmer, George Edmonds, Edwards, Spaulding, John Belford, Davis, Eldred Keays, Samuel Ball, Hemeneway, Palmer,

Front Row: Charles VanValkenberg, Paul Dickey, Herbert Graver, Paul Jones, Everett Sweeley, Charles Carter, Albert Herrnstein, Ross Kidston, George Gregory, William Weeks, James Knight, Norman Sterry, Curtis Redden, Harold Baker, Moses Johnson, James Maynard, Frederick Woodward, Chris Cron, Chester Apel, Cooley, John Lewis

The highway : the motor vehicle, and the community.

Mode of access: Internet.

Black Tournai fonts in England, the group of seven late Norman fonts from Belgium,

Bibliography: p. 31-32.

Vita Sancti Tathei and Buched Seint y Katrin /

Mode of access: Internet.

The complete works of William Shakespeare,

At head of title: New national edition.

The cultivation of shellac as an agricultural product,

Letterpress accompanies the frontispiece.