A slide scanner input for paramatrix,

"Supported in part by the Office of Naval Research. Contract no.N00014-67-A-0305-0007."

Subcellular localization determines MAP kinase signal output

The Raf-MEK-ERK MAP kinase cascade transmits signals from activated receptors into the cell to regulate proliferation and differentiation. The cascade is controlled by the Ras GTPase, which recruits Raf from the cytosol to the plasma membrane for activation. In turn, MEK, ERK, and scaffold proteins translocate to the plasma membrane for activation. Here, we examine the input-output properties of the Raf-MEK-ERK MAP kinase module in mammalian cells activated in different cellular contexts. We show that the MAP kinase module operates as a molecular switch in vivo but that the input sensitivity of the module is determined by subcellular location. Signal output from the module is sensitive to low-level input only when it is activated at the plasma membrane. This is because the threshold for activation is low at the plasma membrane, whereas the threshold for activation is high in the cytosol. Thus, the circuit configuration of the module at the plasma membrane generates maximal outputs from low-level analog inputs, allowing cells to process and respond appropriately to physiological stimuli. These results reveal the engineering logic behind the recruitment of elements of the module from the cytosol to the membrane for activation.

Una Estimación del Impacto del Gasto en Atención a la Dependencia en Andalucía

La atención a la dependencia es, sin lugar a dudas, uno de los grandes retos de futuro de las sociedades que envejecen aceleradamente, al que España y Andalucía no sólo no son ajenos, sino que presentan rasgos que lo amplifican. Sin embargo, es un fenómeno que adolece de importantes lagunas de información, fundamentalmente la carencia de una perspectiva integral que conecte la realidad social, el cambio económico, y la necesidad de transformación de los modelos de bienestar en general y de cuidados en particular, el gasto necesario para su desarrollo y el impacto económico asociado; enfoque holístico que se adopta en este trabajo. Dentro del marco expuesto el objetivo principal del trabajo es cuantificar el impacto en términos de actividad, empleo y retorno fiscal, así como la relación entre la prestación recibida y las características de los dependientes, que permita avanzar en la consideración de este gasto social como una inversión. Para la estimación de los impactos se ha utilizado el Marco Input-Output de Andalucía (MIOAN) de 2010. No obstante, para calcular los incrementos de renta generados por los requerimientos producidos, se ha endogeneizado la demanda de consumo, esto ha implicado construir expresamente para este cálculo una matriz ampliada de Leontief, procediendo a una estimación especifica de la fila adicional ampliada. Finalmente para estimar la relación entre prestación y características de los dependientes se han construido distintos modelos logísticos binarios, y un modelo multinomial. Desarrollado el trabajo de investigación y cuantificado el impacto, la conclusión fundamental no es sólo fuerte efecto arrastre del gasto en dependencia en la actividad y el empleo , sino que se produce en el marco de un cambio irreversible que sitúa a los Cuidados de Larga Duración asociados a la dependencia con un papel central en el contexto de la evolución del Estado el Bienestar. En concreto se ha verificado que: • Andalucía realiza un elevado gasto en atención a la dependencia, 1314 millones de euros, un 85 % del cual total es público y un 15 % privado, y que este gasto genera un fuerte impacto en la economía andaluza, pues su contribución a los grandes agregados macroeconómicos de Andalucía es de un 0,9 % del PIB, superior al impulso de demanda que supone el gasto en atención a la dependencia. • La atención a la dependencia ha mostrado una elevada capacidad de generación de empleo, más de 40.000 empleos, muy concentrado además en personas de difícil inserción en el mercado laboral, mujeres maduras de cualificación media-baja y con poca experiencia acreditable en sector formal de la atención. • La relación entre usuarios, gasto, e impacto para las trasferencias y los servicios muestra un modelo en escalera que caracteriza un sistema de universalización de coste medio con impacto moderado. Un modelo en el que las transferencias suponen el 50 % de los atendidos, el 30 % del gasto y el 20 % del impacto. • El retorno fiscal generado por la dependencia es muy elevado, casi del 45%. • El esfuerzo financiero, tanto bruto como neto, descontado el retorno vía impuestos que obtiene de cada administración, es muy asimétrico lo que puede generar un efecto desincentivador del desarrollo de un modelo con más servicios frente a transferencias. • Las características de los dependientes condicionan la prestación que parece ajustarse a los la características personales y de grado de discapacidad más que las socioeconómicas.

Bienes de capital, flujos tecnológicos y cambio estructural: los casos de Estados Unidos, Japón y Alemania, 1980-2005

La innovación tecnológica se encuentra estrechamente vinculada con el desenvolvimiento de la estructura productiva. Durante mucho tiempo, esta relación era muy evidente, ya que la tecnología como fuente impulsora del crecimiento se asociaba a la inversión en maquinaria y equipo. Ésta última, integraba el componente de innovación que generaba el incremento en productividad. El modelo neoclásico ortodoxo centro el estudio del crecimiento económico en el estudio de Solow (1957), quien explica que la fuente del crecimiento se encuentra en un factor exógeno, que identifica como cambio tecnológico y, de esta manera, resta importancia a la inversión como un determinante del incremento en el producto. En consecuencia, los aportes teóricos recientes, particularmente el neoclásico, centran su atención en los factores que inciden en la generación y desarrollo de innovaciones, pero dejan de lado la vinculación con la estructura económica. En este trabajo se analiza la importancia de los bienes de capital en Alemania, Japón y Estados Unidos, empleando tablas input-output, durante 1980 y 2005, definiendo la vinculación entre cambio tecnológico y la estructura productiva. 1. Síntesis El objetivo es demostrar que la industria de bienes de capital vincula la dinámica tecnológica y los procesos de innovación con el desenvolvimiento de la estructura productiva, por ser clave en el desarrollo económico como fuerza motriz del sistema al generar cambio tecnológico, transferir innovaciones y articular el cambio tecnológico con la estructura productiva. De la Tesis se extraen los siguientes resultados: a) Desde una visión teórica Nathan Rosenberg justifica la importancia de los bienes de capital, por su capacidad de generar cambio tecnológico incorporado, así como por su carácter articulador con otros sectores productivos, favoreciendo el proceso de desarrollo económico. Por el lado metodológico, el análisis input-output resulta ser el más idóneo para el propósito de la investigación. b) La importancia del cambio tecnológico Mediante el estudio de patentes, se demostró que la dinámica de innovación del sector está relacionada con los flujos de conocimiento, al crear y difundir innovaciones, y por su habilidad de asimilar los avances generados en otros sectores. Con el empleo del “Análisis de Flujo Mínimo”, se determina que los bienes de capital juegan un papel destacado por sus efectos de propagación del esfuerzo innovador; asimismo, por ser generadores de innovaciones, su inversión en I+D se traduce en una alta capacidad para impactar a los sectores con los que se vincula...

Competitiveness of the Indonesian construction industry

Indonesia’s construction industry is important to the national economy. However, its competitiveness is considered low due to the lack of success of its development strategy and policy. A new approach known as the cluster approach is being used to make strategy and policy in order to develop a stronger, and more competitive industry. This paper discusses the layout of the Indonesian construction cluster and its competitiveness. The archival analysis research approach was used to identify the construction cluster. The analysis was based on the input-output (I/O) tables of the years 1995 and 2000, which were published by the Indonesian Central Bureau of Statistics. The results suggest that the Indonesian construction cluster consists of the industries directly involved in construction as the core, with the other related and supporting industries as the balance. The anatomy of the Indonesian construction cluster permits structural changes to happen within it. These changes depend on policies that regulate the cluster’s constituents

Integrating hardware and software information flow analyses

Security-critical communications devices must be evaluated to the highest possible standards before they can be deployed. This process includes tracing potential information flow through the device's electronic circuitry, for each of the device's operating modes. Increasingly, however, security functionality is being entrusted to embedded software running on microprocessors within such devices, so new strategies are needed for integrating information flow analyses of embedded program code with hardware analyses. Here we show how standard compiler principles can augment high-integrity security evaluations to allow seamless tracing of information flow through both the hardware and software of embedded systems. This is done by unifying input/output statements in embedded program execution paths with the hardware pins they access, and by associating significant software states with corresponding operating modes of the surrounding electronic circuitry.

An instrument to measure the approach to learning for assessment in economics

Economics education research studies conducted in the UK, USA and Australia to investigate the effects of learning inputs on academic performance have been dominated by the input-output model (Shanahan and Meyer, 2001). In the Student Experience of Learning framework, however, the link between learning inputs and outputs is mediated by students' learning approaches which in turn are influenced by their perceptions of the learning contexts (Evans, Kirby, & Fabrigar, 2003). Many learning inventories such as Biggs' Study Process Questionnaires and Entwistle and Ramsden' Approaches to Study Inventory have been designed to measure approaches to academic learning. However, there is a limitation to using generalised learning inventories in that they tend to aggregate different learning approaches utilised in different assessments. As a result, important relationships between learning approaches and learning outcomes that exist in specific assessment context(s) will be missed (Lizzio, Wilson, & Simons, 2002). This paper documents the construction of an assessment specific instrument to measure learning approaches in economics. The post-dictive validity of the instrument was evaluated by examining the association of learning approaches to students' perceived assessment demand in different assessment contexts.

Robot building for preschoolers

This paper describes Electronic Blocks, a new robot construction element designed to allow children as young as age three to build and program robotic structures. The Electronic Blocks encapsulate input, output and logic concepts in tangible elements that young children can use to create a wide variety of physical agents. The children are able to determine the behavior of these agents by the choice of blocks and the manner in which they are connected. The Electronic Blocks allow children without any knowledge of mechanical design or computer programming to create and control physically embodied robots. They facilitate the development of technological capability by enabling children to design, construct, explore and evaluate dynamic robotics systems. A study of four and five year-old children using the Electronic Blocks has demonstrated that the interface is well suited to young children. The complexity of the implementation is hidden from the children, leaving the children free to autonomously explore the functionality of the blocks. As a consequence, children are free to move their focus beyond the technology. Instead they are free to focus on the construction process, and to work on goals related to the creation of robotic behaviors and interactions. As a resource for robot building, the blocks have proved to be effective in encouraging children to create robot structures, allowing children to design and program robot behaviors.

Beyond a battery hen model? : a computer laboratory, micropolitics and educational change

This paper investigates what happened in one Australian primary school as part of the establishment, use and development of a computer laboratory over a period of two years. As part of a school renewal project, the computer lab was introduced as an ‘innovative’ way to improve the skills of teachers and children in information and communication technologies (ICT) and to lead to curriculum change. However, the way in which the lab was conceptualised and used worked against achieving these goals. The micropolitics of educational change and an input-output understanding of computers meant that change remained structural rather pedagogical or philosophical.

The PSS : From Flat Maps to Layered Perspectives - the contribution of the Airport Metropolis Planning Support System (PSS) to sub-regional planning in the Brisbane Airport case environment

Conventional planning and decision making, with its sectoral and territorial emphasis and flat-map based processes are no longer adequate or appropriate for the increased complexity confronting airport/city interfaces. These crowed and often contested governance spaces demand a more iterative and relational planning and decision-making approach. Emergent GIS based planning and decision-making tools provide a mechanism which integrate and visually display an array of complex data, frameworks and scenarios/expectations, often in ‘real time’ computations. In so doing, these mechanisms provide a common ground for decision making and facilitate a more ‘joined-up’ approach to airport/city planning. This paper analyses the contribution of the Airport Metropolis Planning Support System (PSS) to sub-regional planning in the Brisbane Airport case environment.

Triangular Linguistic Fuzzy based performance measurement model for supply chain to assess leanness attributes

Increasing global competitiveness worldwide has forced manufacturing organizations to produce high-quality products more quickly and at a competitive cost. In order to reach these goals, they need good quality components from suppliers at optimum price and lead time. This actually forced all the companies to adapt different improvement practices such as lean manufacturing, Just in Time (JIT) and effective supply chain management. Applying new improvement techniques and tools cause higher establishment costs and more Information Delay (ID). On the contrary, these new techniques may reduce the risk of stock outs and affect supply chain flexibility to give a better overall performance. But industry people are unable to measure the overall affects of those improvement techniques with a standard evaluation model .So an effective overall supply chain performance evaluation model is essential for suppliers as well as manufacturers to assess their companies under different supply chain strategies. However, literature on lean supply chain performance evaluation is comparatively limited. Moreover, most of the models assumed random values for performance variables. The purpose of this paper is to propose an effective supply chain performance evaluation model using triangular linguistic fuzzy numbers and to recommend optimum ranges for performance variables for lean implementation. The model initially considers all the supply chain performance criteria (input, output and flexibility), converts the values to triangular linguistic fuzzy numbers and evaluates overall supply chain performance under different situations. Results show that with the proposed performance measurement model, improvement area for each variable can be accurately identified.

Optimal sitting and sizing of distributed generators considering plug-in electric vehicles

Some uncertainties such as the stochastic input/output power of a plug-in electric vehicle due to its stochastic charging and discharging schedule, that of a wind unit and that of a photovoltaic generation source, volatile fuel prices and future uncertain load growth, all together could lead to some risks in determining the optimal siting and sizing of distributed generators (DGs) in distributed systems. Given this background, under the chance constrained programming (CCP) framework, a new method is presented to handle these uncertainties in the optimal sitting and sizing problem of DGs. First, a mathematical model of CCP is developed with the minimization of DGs investment cost, operational cost and maintenance cost as well as the network loss cost as the objective, security limitations as constraints, the sitting and sizing of DGs as optimization variables. Then, a Monte Carolo simulation embedded genetic algorithm approach is developed to solve the developed CCP model. Finally, the IEEE 37-node test feeder is employed to verify the feasibility and effectiveness of the developed model and method. This work is supported by an Australian Commonwealth Scientific and Industrial Research Organisation (CSIRO) Project on Intelligent Grids Under the Energy Transformed Flagship, and Project from Jiangxi Power Company.

Development of distributed fuzzy systems with a runtime-adaptable mobile components framework

A distributed fuzzy system is a real-time fuzzy system in which the input, output and computation may be located on different networked computing nodes. The ability for a distributed software application, such as a distributed fuzzy system, to adapt to changes in the computing network at runtime can provide real-time performance improvement and fault-tolerance. This paper introduces an Adaptable Mobile Component Framework (AMCF) that provides a distributed dataflow-based platform with a fine-grained level of runtime reconfigurability. The execution location of small fragments (possibly as little as few machine-code instructions) of an AMCF application can be moved between different computing nodes at runtime. A case study is included that demonstrates the applicability of the AMCF to a distributed fuzzy system scenario involving multiple physical agents (such as autonomous robots). Using the AMCF, fuzzy systems can now be developed such that they can be distributed automatically across multiple computing nodes and are adaptable to runtime changes in the networked computing environment. This provides the opportunity to improve the performance of fuzzy systems deployed in scenarios where the computing environment is resource-constrained and volatile, such as multiple autonomous robots, smart environments and sensor networks.

BabelFuse data fusion unit with precision wireless clock synchronisation

A significant issue encountered when fusing data received from multiple sensors is the accuracy of the timestamp associated with each piece of data. This is particularly important in applications such as Simultaneous Localisation and Mapping (SLAM) where vehicle velocity forms an important part of the mapping algorithms; on fastmoving vehicles, even millisecond inconsistencies in data timestamping can produce errors which need to be compensated for. The timestamping problem is compounded in a robot swarm environment due to the use of non-deterministic readily-available hardware (such as 802.11-based wireless) and inaccurate clock synchronisation protocols (such as Network Time Protocol (NTP)). As a result, the synchronisation of the clocks between robots can be out by tens-to-hundreds of milliseconds making correlation of data difficult and preventing the possibility of the units performing synchronised actions such as triggering cameras or intricate swarm manoeuvres. In this thesis, a complete data fusion unit is designed, implemented and tested. The unit, named BabelFuse, is able to accept sensor data from a number of low-speed communication buses (such as RS232, RS485 and CAN Bus) and also timestamp events that occur on General Purpose Input/Output (GPIO) pins referencing a submillisecondaccurate wirelessly-distributed "global" clock signal. In addition to its timestamping capabilities, it can also be used to trigger an attached camera at a predefined start time and frame rate. This functionality enables the creation of a wirelessly-synchronised distributed image acquisition system over a large geographic area; a real world application for this functionality is the creation of a platform to facilitate wirelessly-distributed 3D stereoscopic vision. A ‘best-practice’ design methodology is adopted within the project to ensure the final system operates according to its requirements. Initially, requirements are generated from which a high-level architecture is distilled. This architecture is then converted into a hardware specification and low-level design, which is then manufactured. The manufactured hardware is then verified to ensure it operates as designed and firmware and Linux Operating System (OS) drivers are written to provide the features and connectivity required of the system. Finally, integration testing is performed to ensure the unit functions as per its requirements. The BabelFuse System comprises of a single Grand Master unit which is responsible for maintaining the absolute value of the "global" clock. Slave nodes then determine their local clock o.set from that of the Grand Master via synchronisation events which occur multiple times per-second. The mechanism used for synchronising the clocks between the boards wirelessly makes use of specific hardware and a firmware protocol based on elements of the IEEE-1588 Precision Time Protocol (PTP). With the key requirement of the system being submillisecond-accurate clock synchronisation (as a basis for timestamping and camera triggering), automated testing is carried out to monitor the o.sets between each Slave and the Grand Master over time. A common strobe pulse is also sent to each unit for timestamping; the correlation between the timestamps of the di.erent units is used to validate the clock o.set results. Analysis of the automated test results show that the BabelFuse units are almost threemagnitudes more accurate than their requirement; clocks of the Slave and Grand Master units do not di.er by more than three microseconds over a running time of six hours and the mean clock o.set of Slaves to the Grand Master is less-than one microsecond. The common strobe pulse used to verify the clock o.set data yields a positive result with a maximum variation between units of less-than two microseconds and a mean value of less-than one microsecond. The camera triggering functionality is verified by connecting the trigger pulse output of each board to a four-channel digital oscilloscope and setting each unit to output a 100Hz periodic pulse with a common start time. The resulting waveform shows a maximum variation between the rising-edges of the pulses of approximately 39¥ìs, well below its target of 1ms.