Economic benefits and costs of technologies for sustainable land management (SLM): a preliminary analysis of global WOCAT data

The WOCAT network has collected, documented, and assessed more than 350 case studies on promising and good practices of SLM. Information on on- and off-site benefits of different SLM types, as well as on investment and maintenance costs is available, sometimes in quantitative and often in qualitative form. The objective of the present paper is to analyse what kind of economic benefits accrue to local stakeholders, and to better understand how these benefits compare to investment and maintenance costs. The large majority of the technologies contained in the database are perceived by land users as having positive benefits that outweigh costs in the long term. About three quarters of them also have positive or at least neutral benefits in the short term. The analysis shows that many SLM measures exist which can generate important benefits to land users, but also to other stakeholders. However, methodological issues need to be tackled and further quantitative and qualitative data are needed to better understand and support the adoption of SLM measures. Keywords: Sustainable Land Management, Costs, Benefits, Technologies

Risk, outcomes, and cost of emergency center visits in cancer patients

Cancer is a chronic disease that often necessitates recurrent hospitalizations, a costly pattern of medical care utilization. In chronically ill patients, most readmissions are for treatment of the same condition that caused the preceding hospitalization. There is concern that rather than reducing costs, earlier discharge may shift costs from the initial hospitalization to emergency center visits. ^ This is the first descriptive study to measure the incidence of emergency center visits (ECVs) after hospitalization at The University of M. D. Anderson Cancer Center (UTMDACC), to identify the risk factors for and outcomes of these ECVs, and to compare 30-day all-cause mortality and costs for episodes of care with and without ECVs. ^ We identified all hospitalizations at UTMDACC with admission dates from September 1, 1993 through August 31, 1997 which met inclusion criteria. Data were electronically obtained primarily from UTMDACC's institutional database. Demographic factors, clinical factors, duration of the index hospitalization, method of payment for care, and year of hospitalization study were variables determined for each hospitalization. ^ The overall incidence of ECVs was 18%. Forty-five percent of ECVs resulted in hospital readmission (8% of all hospitalizations). In 1% of ECVs the patient died in the emergency center, and for the remaining 54% of ECVs the patient was discharged home. Risk factors for ECVs were marital status, type of index hospitalization, cancer type, and duration of the index hospitalization. The overall 30-day all-cause mortality rate was 8.6% for hospitalizations with an ECV and 5.3% for those without an ECV. In all subgroups, the 30-day all-cause mortality rate was higher for groups with ECVs than for those without ECVs. The most important factor increasing cost was having an ECV. In all patient subgroups, the cost per episode of care with an ECV was at least 1.9 times the cost per episode without an ECV. ^ The higher costs and poorer outcomes of episodes of care with ECVs and hospital readmissions suggest that interventions to avoid these ECVs or mitigate their costs are needed. Further research is needed to improve understanding of the methodological issues involved in relation to health care issues for cancer patients. ^

Factorial designs: an overview with applications to orthodontic clinical trials.

Factorial designs for clinical trials are often encountered in medical, dental, and orthodontic research. Factorial designs assess two or more interventions simultaneously and the main advantage of this design is its efficiency in terms of sample size as more than one intervention may be assessed on the same participants. However, the factorial design is efficient only under the assumption of no interaction (no effect modification) between the treatments under investigation and, therefore, this should be considered at the design stage. Conversely, the factorial study design may also be used for the purpose of detecting an interaction between two interventions if the study is powered accordingly. However, a factorial design powered to detect an interaction has no advantage in terms of the required sample size compared to a multi-arm parallel trial for assessing more than one intervention. It is the purpose of this article to highlight the methodological issues that should be considered when planning, analysing, and reporting the simplest form of this design, which is the 2 × 2 factorial design. An example from the field of orthodontics using two parameters (bracket type and wire type) on maxillary incisor torque loss will be utilized in order to explain the design requirements, the advantages and disadvantages of this design, and its application in orthodontic research.

Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.

Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degradation by the fatty acid amide hydrolase (FAAH). Differential blockage of each mechanism is possible using specific small-molecule inhibitors. Starting from the natural product-derived 2E,4E-dodecadiene scaffold previously shown to interact with the endocannabinoid system (ECS), a series of diverse N-alkylcarbamates were prepared with the aim of generating novel ECS modulators. While being inactive at cannabinoid receptors and monoacylglycerol lipase, these N-alkylcarbamates showed potent to ultrapotent picomolar FAAH inhibition in U937 cells. Overall, a highly significant correlation (Spearman's rho=0.91) was found between the inhibition of FAAH and AEA cellular uptake among 54 compounds. Accordingly, in HMC-1 cells lacking FAAH expression the effect on AEA cellular uptake was dramatically reduced. Unexpectedly, 3-(4,5-dihydrothiazol-2-yl)phenyl carbamates and the 3-(1,2,3-thiadiazol-4-yl)phenyl carbamates WOBE490, WOBE491 and WOBE492 showed a potentiation of cellular AEA uptake inhibition in U937 cells, resulting in unprecedented femtomolar (hyperpotent) IC50 values. Potential methodological issues and the role of cellular accumulation of selected probes were investigated. It is shown that albumin impacts the potency of specific N-alkylcarbamates and, more importantly, that accumulation of FAAH inhibitors can significantly increase their effect on cellular AEA uptake. Taken together, this series of N-alkylcarbamates shows a FAAH-dependent inhibition of cellular AEA uptake, which can be strongly potentiated using specific head group modifications. These findings provide a rational basis for the development of hyperpotent AEA uptake inhibitors mediated by ultrapotent FAAH inhibition.

Reflexiones metodológicas sobre algunas contribuciones de la terapia familiar sistémica a un estudio antropológico de la familia

El fenómeno migratorio ha sido tratado a partir de diferentes estudios históricos, sociológicos, demográficos y antropológicos. Muchas veces estos abordajes solo ofrecen respuestas parciales a las problemáticas que conforman la migración. Nuestras investigaciones se centraron en el estudio de grupos de inmigrantes caboverdeanos en Argentina, aportando modelos sobre la organización e interacción de esos grupos, con el fin de explorar temas críticos, como inmigración y familia, identidad y etnicidad, entre otros. Luego de años de trabajo hemos ajustado metodologías, sobre todo las derivadas de la antropología tradicional, buscando alternativas, "reciclando" premisas, pautas y técnicas de otras disciplinas como la psicología (en particular la terapia familiar de orientación sistémica). En este trabajo reflexionamos sobre algunas cuestiones metodológicas, particularmente el uso de genogramas puestos en práctica en el estudio del parentesco y de la familia caboverdeana en un contexto migratorio, cuyo análisis fue uno de los objetivos planteados en el proyecto de investigación sobre el mencionado grupo en la Argentina

Reflexiones metodológicas sobre algunas contribuciones de la terapia familiar sistémica a un estudio antropológico de la familia

El fenómeno migratorio ha sido tratado a partir de diferentes estudios históricos, sociológicos, demográficos y antropológicos. Muchas veces estos abordajes solo ofrecen respuestas parciales a las problemáticas que conforman la migración. Nuestras investigaciones se centraron en el estudio de grupos de inmigrantes caboverdeanos en Argentina, aportando modelos sobre la organización e interacción de esos grupos, con el fin de explorar temas críticos, como inmigración y familia, identidad y etnicidad, entre otros. Luego de años de trabajo hemos ajustado metodologías, sobre todo las derivadas de la antropología tradicional, buscando alternativas, "reciclando" premisas, pautas y técnicas de otras disciplinas como la psicología (en particular la terapia familiar de orientación sistémica). En este trabajo reflexionamos sobre algunas cuestiones metodológicas, particularmente el uso de genogramas puestos en práctica en el estudio del parentesco y de la familia caboverdeana en un contexto migratorio, cuyo análisis fue uno de los objetivos planteados en el proyecto de investigación sobre el mencionado grupo en la Argentina

Reflexiones metodológicas sobre algunas contribuciones de la terapia familiar sistémica a un estudio antropológico de la familia

El fenómeno migratorio ha sido tratado a partir de diferentes estudios históricos, sociológicos, demográficos y antropológicos. Muchas veces estos abordajes solo ofrecen respuestas parciales a las problemáticas que conforman la migración. Nuestras investigaciones se centraron en el estudio de grupos de inmigrantes caboverdeanos en Argentina, aportando modelos sobre la organización e interacción de esos grupos, con el fin de explorar temas críticos, como inmigración y familia, identidad y etnicidad, entre otros. Luego de años de trabajo hemos ajustado metodologías, sobre todo las derivadas de la antropología tradicional, buscando alternativas, "reciclando" premisas, pautas y técnicas de otras disciplinas como la psicología (en particular la terapia familiar de orientación sistémica). En este trabajo reflexionamos sobre algunas cuestiones metodológicas, particularmente el uso de genogramas puestos en práctica en el estudio del parentesco y de la familia caboverdeana en un contexto migratorio, cuyo análisis fue uno de los objetivos planteados en el proyecto de investigación sobre el mencionado grupo en la Argentina

Remarks on Compositionality (with reference to Gennadij Zeldoviè's article “On Russian Dative Reflexive Constructions: Accidental or Compositional”)

Zeldovič’s article “On Russian Dative Reflexive Constructions: Accidental or Compositional” is very interesting. It contains a good deal of insightful observations and is painstakingly argued. Its research object is the Russian dative reflexive construction (DRC) like Ивану не работается ‘Ivan does not feel like reading’. The aim of the article is to show that the DRC is fully compositional. Like many other works by Zeldovič, the article is written from the radical-pragmatic perspective and constitutes a very good illustration of this trend in linguistic research. The language material that it analyzes has often been investigated within more traditional frameworks, especially in Russian linguistics, which makes Zeldovič’s novel approach to the old problem particularly interesting. In this short note I would like (by way of discussion) to address two problems connected not so much with the DRC itself as with methodological issues concerning compositionality. I will dwell on two aspects: on the question of how we understand the very concept of compositionality, and what instruments we employ to demonstrate it.

Comparasion of road traffic emission models in Madrid (Spain)

Many cities in Europe have difficulties to meet the air quality standards set by the European legislation, most particularly the annual mean Limit Value for NO2. Road transport is often the main source of air pollution in urban areas and therefore, there is an increasing need to estimate current and future traffic emissions as accurately as possible. As a consequence, a number of specific emission models and emission factors databases have been developed recently. They present important methodological differences and may result in largely diverging emission figures and thus may lead to alternative policy recommendations. This study compares two approaches to estimate road traffic emissions in Madrid (Spain): the COmputer Programme to calculate Emissions from Road Transport (COPERT4 v.8.1) and the Handbook Emission Factors for Road Transport (HBEFA v.3.1), representative of the ‘average-speed’ and ‘traffic situation’ model types respectively. The input information (e.g. fleet composition, vehicle kilometres travelled, traffic intensity, road type, etc.) was provided by the traffic model developed by the Madrid City Council along with observations from field campaigns. Hourly emissions were computed for nearly 15 000 road segments distributed in 9 management areas covering the Madrid city and surroundings. Total annual NOX emissions predicted by HBEFA were a 21% higher than those of COPERT. The discrepancies for NO2 were lower (13%) since resulting average NO2/NOX ratios are lower for HBEFA. The larger differences are related to diesel vehicle emissions under “stop & go” traffic conditions, very common in distributor/secondary roads of the Madrid metropolitan area. In order to understand the representativeness of these results, the resulting emissions were integrated in an urban scale inventory used to drive mesoscale air quality simulations with the Community Multiscale Air Quality (CMAQ) modelling system (1 km2 resolution). Modelled NO2 concentrations were compared with observations through a series of statistics. Although there are no remarkable differences between both model runs, the results suggest that HBEFA may overestimate traffic emissions. However, the results are strongly influenced by methodological issues and limitations of the traffic model. This study was useful to provide a first alternative estimate to the official emission inventory in Madrid and to identify the main features of the traffic model that should be improved to support the application of an emission system based on “real world” emission factors.

Residential self-selection and geographical scales in trip frequency.

Neighbourhood representation and scale used to measure the built environment have been treated in many ways. However, it is anything but clear what representation of neighbourhood is the most feasible in the existing literature. This paper presents an exhaustive analysis of built environment attributes through three spatial scales. For this purpose multiple data sources are integrated, and a set of 943 observations is analysed. This paper simultaneously analyses the influence of two methodological issues in the study of the relationship between built environment and travel behaviour: (1) detailed representation of neighbourhood by testing different spatial scales; (2) the influence of unobserved individual sensitivity to built environment attributes. The results show that different spatial scales of built environment attributes produce different results. Hence, it is important to produce local and regional transport measures, according to geographical scale. Additionally, the results show significant sensitivity to built environment attributes depending on place of residence. This effect, called residential sorting, acquires different magnitudes depending on the geographical scale used to measure the built environment attributes. Spatial scales risk to the stability of model results. Hence, transportation modellers and planners must take into account both effects of self-selection and spatial scales.