240 resultados para Mercer


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Myosin Va is associated with discrete vesicle populations in a number of cell types, but little is known of the function of myosin Vb. Yeast two-hybrid screening of a rabbit parietal cell cDNA library with dominant active Rab11a (Rab11aS20V) identified myosin Vb as an interacting protein for Rab11a, a marker for plasma membrane recycling systems. The isolated clone, corresponding to the carboxyl terminal 60 kDa of the myosin Vb tail, interacted with all members of the Rab11 family (Rab11a, Rab11b, and Rab25). GFP-myosin Vb and endogenous myosin Vb immunoreactivity codistributed with Rab11a in HeLa and Madin-Darby canine kidney (MDCK) cells. As with Rab11a in MDCK cells, the myosin Vb immunoreactivity was dispersed with nocodazole treatment and relocated to the apical corners of cells with taxol treatment. A green fluorescent protein (GFP)-myosin Vb tail chimera overexpressed in HeLa cells retarded transferrin recycling and caused accumulation of transferrin and the transferrin receptor in pericentrosomal vesicles. Expression of the myosin Vb tail chimera in polarized MDCK cells stably expressing the polymeric IgA receptor caused accumulation of basolaterally endocytosed polymeric IgA and the polymeric IgA receptor in the pericentrosomal region. The myosin Vb tail had no effects on transferrin trafficking in polarized MDCK cells. The GFP-myosin Va tail did not colocalize with Rab11a and had no effects on recycling system vesicle distribution in either HeLa or MDCK cells. The results indicate myosin Vb is associated with the plasma membrane recycling system in nonpolarized cells and the apical recycling system in polarized cells. The dominant negative effects of the myosin Vb tail chimera indicate that this unconventional myosin is required for transit out of plasma membrane recycling systems.

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We have isolated cDNAs encoding a second member of the dilute (myosin-V) unconventional myosin family in vertebrates, myr 6 (myosin from rat 6). Expression of myr 6 transcripts in the brain is much more limited than is the expression of dilute, with highest levels observed in choroid plexus and components of the limbic system. We have mapped the myr 6 locus to mouse chromosome 18 using an interspecific backcross. The 3' portion of the myr 6 cDNA sequence from rat is nearly identical to that of a previously published putative glutamic acid decarboxylase from mouse [Huang, W.M., Reed-Fourquet, L., Wu, E. & Wu, J.Y. (1990) Proc. Natl. Acad. Sci. USA 87, 8491-8495].

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El proceso de la maternidad, según Mercer, implica que la madre nazca psicológicamente, dando lugar a una nueva identidad en constante crecimiento y desarrollo. El modelo de esta autora puede servir a la enfermera para valorar, planificar, ejecutar y evaluar el cuidado enfermero de las madres y sus bebés en sus intervenciones. Este estudio cualitativo, de enfoque etnográfico, dirigido a grupos de madres con hijos menores de un año, utilizará la observación participante y el diario de campo para describir y relacionar los contenidos de las dinámicas grupales con el desarrollo del rol maternal. Se identifican 3 categorías y 50 códigos y se destaca que las enfermeras, como profesionales competentes en aspectos conceptuales y técnicos propios de su disciplina, utilizan los modelos de Mercer y Beck para acompañar a las madres coordinándose con otros profesionales.

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Legal opinion on an equity case (1798). Four letters to an unnamed correspondent (1801) regarding a shipment of papers; Joseph Hopkinson, member of Congress (1817) regarding a judiciary bill; a note (1818) to the cashier of the Bank of Columbia; and to Charles T. Mercer (1823) regarding property in Loudoun County, Virginia. Folder also contains newspaper clippings (ca. 1830-1842) regarding Washington's life and career, including one taken from the Journal of Law.

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Andrew Croswell kept this account book while an undergraduate at Harvard College. It contains entries from 1794, the year he entered, until his graduation in 1798. There is also one entry on the back cover apparently made in 1802. The entries, divided by school term, are very detailed. Croswell indicates the cost of the following, among many other expenses and purchases: transportation, most often to Hingham and Plymouth; payment for "passing the bridge"; candles; hiring a horse; wood and having it cut; laundry; quills and pencils; paper and ink; razors, haircuts, hair ribbons; a trunk; clothing and cloth for trousers; furniture; tickets to the theater; door locks; a bowl and spoon; "batts and balls" and "other necessaries"; tobacco; toothbrushes; shoe and boot repair; fruit; wine, brandy and rum; cheese; coffee and tea; butter; lemons; sugar; and wafers. There are also entries for college-related costs, including the payment of quarter bills, buttery bills, Hasty Pudding Club dues, and a fee to the President of Harvard College related to Croswell's graduation. There are also entries pertaining to the cost of celebrating various special occasions, including Election Day, Christmas Eve, "Independent Day," and George Washington's birthday.

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This layer is a georeferenced raster image of the historic paper map entitled: Map of the country around Philadelphia : with the good roads specially marked. It was published by J. L. Smith in 1897. Scale [1:63,360]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Pennsylvania South State Plane Coordinate System NAD83 (in Feet) (Fipszone 3702). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads ("Good roads" are shown in red), railroads, drainage, canals, selected buildings, towns, county and state boundies, and more. Includes explanation of signs. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

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This layer is a georeferenced raster image of the historic paper map entitled: Whitney's map of Seattle and environs, Washington, compiled from official records by O.P. Anderson and Co., engineers and draughtsmen, 1890. It was published by W.H. Whitney in 1890. Scale [ca. 1:30,600]. Covers portions of Seattle and surrounding cities. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Washington State Plane North Coordinate System HARN NAD83 (in Feet) (Fipszone 4601). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, ferry lines, drainage, names of selected landowners, and more. Includes insets of the Seattle region and the state of Washington, and Union Pacific Railroad Co. logo. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

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A reconnaissance study of alkenone stratigraphy for the past 35 m.y. in the northern South China Sea (SCS) using sediments from Sites 1147 and 1148 of Ocean Drilling Program (ODP) Leg 184 has been completed. Alkenones were not detected in sediment samples older than ~31 Ma. However, C37:2 appeared in the sedimentary record between ~8 and 31 Ma and both C37:2 and C37:3 were present between 0 and 8 Ma. These changes in alkenone occurrences may signal a response to global-scale Neogene cooling as well as to monsoon intensification and sea level changes over time as a result of Himalayan uplift and the opening of the SCS. Alternatively, they may be related to an evolutionary record of the development of temperature control on alkenone production in coccolithophores. The Uk'37 index for 0-8 Ma produces sea-surface temperatures (SST) of 19°-26°C, which are in the range of previously determined glacial-interglacial values for the northern SCS. Before the late Pleistocene (~1.2 Ma), the SST range is between 23° and 26°C with less variation. This change in variability may signify the early stage of intensified winter monsoons where cold wind and waters from the north may not yet have had a significant effect on SST or it may be the evolutionary link between the early development of unsaturated alkenones in coccolithophores and modern temperature control of alkenone production. We believe a long-term alkenone record is useful for further understanding of global-scale neogene cooling, the development of the East Asian monsoon system, and the evolutionary development of temperature control on alkenone unsaturation. Our data indicate that a high-resolution Uk'37 record for at least the last ~8 Ma is feasible for the northern SCS.

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Back Row: Fritz Seyferth, Bob Chmiel, Alex Agase, Jerry Meter, Elliot Uzelac, Paul Schudel, Jerry Hanlon, Gary Moeller, Tirrell Burton, Milan Vooletich, Lloyd Carr, Bob Thornbladh, Dennis Doornbos, Mike Gittleson

9th Row: Chuck Ritter, Jon Falk, Ken Gear, Bob Kimball, Ed Hood, Camp Fellin, Marc Shevrin, Joe Mosketti, Charlie Fromm, Russ Miller

8th Row: Pat Moons, Derek Woodmore, Greg Randall, Triando Markray, Andy Moeller, Mike Krauss, Dan Decker, Jerry Quaerna, Rick Frazer, Dieter Heren, Ben Logue, Keith Cowan, Robert Harris

7th Row: Tony Gant, Steve Johnson, Thomas Wilcher, Eddie Garrett, Paul Schmerge, Mike Reinhold, Marty Shimko, John Mihic, Mark Hammerstein, Jim Harbaugh, Dan Rice, Bob Perryman, Gilvanni Johnson, Ivan Hicks

6th Row: Joe English, Todd Schlopy, Mike Melnyk, John Ferens, Mike Sessa, John Ghindia, Sim Nelson, Gil Zimmerman, Eric Kempthorn, Bruce Brown, Dave Simon, Sylvester Ogletree, John Paciorek, Bob Bergeron

5th Row: Tom Knoebel, Mike Odioso, Phil Lewandowski, Bob Popowski, Clay Miller, Jeff Akers, Kevin Brooks, Art Balourdos, Mike Hammerstein, Brian Mercer, Bob Tabachino, Joe Gray, Jim Scarcelli, Riley McPhee

4th Row: Greg Powell, Brad Cochran, Al Sincinch, Mike Mallory, Eric Kattus, Vince DeFelice, Tim Anderson, Dave Meredith, Larry Sweeney, Mike Wilson, Nate Rodgers, Robert Dana, Rick Rogers, Fritz Burgess

3rd Row: Evan Cooper, Greg Armstrong, Don Bracken, Carlton Rose, Tom Hassell, Kerry Smith, Dave Hall, Jerry Diorio, Ron Prusa, Milt Carthens, Doug James, Rodney Lyles, Mickey Hanlon, Lou Kovacs

2nd Row: Vince Bean, Stefan Humphries, Nate Davis, Ricky Davis, John Lott, Scott Roberts, Todd Triplett, Dan Yarano, Rich Hewlett, Jeff Cohen, Jim Herrman, Steve Smith, Mike Boren, Tom Dixon

Front Row: Marion Body, Jerald Ingram, Mike Lemirande, Winfred Carraway, Craig Dunaway, Keith Bostic, Rich Strenger, Robert Thompson, Anthony Carter, Lawrence Ricks, Paul Girgash, Tom Garrity, Jerry Burgei, Ali Haji-Sheikh, Bo Schembechler

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Back Row: Bill Giarmo, Alex Agase, Jerry Hanlon, Bob Thornbladh, Elliott Uzelac, Gary Moeller, Lloyd Carr, Jerry Meter, Milan Vooletich, Tirrel Burton, Bob Chmiel, Jim Herrmann, Dave Magazu

9th Row: Doug Ham (Mgr.), Mike Gittleson, Lou Kovacs, Joe English, Joe Mosketti, James Rott, Garrett Smith, Phil Logas, John Whitledge, Andy Samosiuk, Dave Garlow, Russ Miller, Fritz Seyferth, Jon Falk

8th Row: Tim Schulte, Mike O'Connor, Billy Harris, Carlitos Bostic, Gene Cecchini, Steve Thibert, Jack Walker, John Balourdos, Pete Wentworth, Todd Schulte, Brandon Johns, Monte Robbins, John Zingales

7th Row: Billy Dawson, Doug Mallory, Gerald White, Garland Rivers, Dave Folkertsma, Andrew Borowski, Glenn Mogle, John Elliott, Andree McIntyre, Dwayne Freeman, Phil Webb, Chris Zurbrugg, Ken Higgins, Russell Rein

6th Row: Gene Lawson, Camp Fellin, Marc Shevrin, Dieter Heren, John Mihic, Jerry Quaerna, Rick Frazer, Marty Shimko, Triando Markray, Dan Decker, Keith Cowan, Pat Moons, Ed Hood, Al Bishop

5th Row: Steve Johnson, Tony Gant, Greg Randall, Ben Logue, Gilvanni Johnson, Paul Schmerge, Mark Hammerstein, Mike Reinhold, Jim Harbaugh, Bob Perryman, Andy Moeller, Mike Krauss, Ivan Hicks

4th Row: Mike Melnyk, Todd Schlopy, John Paciorek, Dave Simon, John Ghindia, Phil Lewandowski, Jim Scarcelli, Brad Cochran, Tom Knoebel, Mike Sessa, Eddie Garrett, Dan Rice, John Ferens, Bob Bergeron, Tom Wilcher

3rd Row: Joe Gray, Mike Mallory, Clay Miller, Eric Kattus, Art Balourdos, Al Sincich, Kevin Brooks, Mike Hammerstein, Sim Nelson, Jeff Akers, Rick Rogers, Bob Popowski, Bob Tabachino, Brian Mercer

2nd Row: Fritz Burgess, Tim Anderson, Mike Wilson, Nate Rogers, Dave Meredith, Vince DeFelice, Greg Armstrong, Milt Carthens, Rodney Lyles, Larry Sweeney, Dan Yarano, Gerald Ingram, Don Bracken, Kerry Smith

Front Row: Jeff Cohen, Jerry Diorio, Dave Hall, Carlton Rose, Steve Smith, Tom Dixon, Stefan Humphries, Mike Boren, Doug James, Evan Cooper, Tom Hassel, John Lott, Vince Bean, Rich Hewlett, Coach Bo Schembechler

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National Highway Traffic Safety Administration, Washington, D.C.

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Mode of access: Internet.

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Aids personal and bibliographical: A word on the almanacs: Notes to frontier humor and legend, p. 164-171.

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Anecdotes and woocuts selected from the Crockett almanacs (1835-1856) cf. Editors̓ note.

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Mode of access: Internet.