992 resultados para Mehmed II, Sultan of the Turks, 1432-1481.


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Appendix: I. The minutes of the Nottingham classis, 1656-60. II. Minutes of the Cornwall classis, 1655-8. III. Minutes of the Cambridge classis, Jany 20, 1656/7 to July 13, 1658. IV. An account of the ministers mentioned in the Bury minutes.

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I. Chemistry of the aliphatic series newly tr. and rev. from the German ed. (after Prof. Edgar F. Smiths's 3d American ed.) by Percy E. Spielman. 1916. ...II. Chemistry of the carbocyclic compounds, tr. from the 11th German ed., by E.E. Fournier d'Albe. 1922. ...III. Heterocyclic compounds, Tr. from the 11th German ed., by E.E. Fournier d'Albe. 1923.

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First published under title: Ante-Nicene Christian library, Edinburgh, 1867-97.

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The work describes the programme of activities relating to a mechanical study of the Conform extrusion process. The main objective was to provide a basic understanding of the mechanics of the Conform process with particular emphasis placed on modelling using experimental and theoretical considerations. The experimental equipment used includes a state of the art computer-aided data-logging system and high temperature loadcells (up to 260oC) manufactured from tungsten carbide. Full details of the experimental equipment is presented in sections 3 and 4. A theoretical model is given in Section 5. The model presented is based on the upper bound theorem using a variation of the existing extrusion theories combined with temperature changes in the feed metal across the deformation zone. In addition, constitutive equations used in the model have been generated from existing experimental data. Theoretical and experimental data are presented in tabular form in Section 6. The discussion of results includes a comprehensive graphical presentation of the experimental and theoretical data. The main findings are: (i) the establishment of stress/strain relationships and an energy balance in order to study the factors affecting redundant work, and hence a model suitable for design purposes; (ii) optimisation of the process, by determination of the extrusion pressure for the range of reduction and changes in the extrusion chamber geometry at lower wheel speeds; and (iii) an understanding of the control of the peak temperature reach during extrusion.

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Ribonucleotide reductases (RNR) are essential enzymes that catalyze the reduction of ribonucleotides to 2'-deoxyribonucleotides, which is a critical step that produces precursors for DNA replication and repair. The inactivation of RNR, logically, would discontinue producing the precursors of the DNA of viral or cancer cells, which then would consequently end the cycle of DNA replication. Among different compounds that were found to be inhibitors of RNR, 2'-azido-2'-deoxynucleotide diphosphates (N3NDPs) have been investigated in depth as potent inhibitors of RNR. Decades of investigation has suggested that the inactivation of RNR by N3NDPs is a result of the formation of a nitrogen-centered radical (N·) that is covalently attached to the nucleotide at C3' and cysteine molecule C225 [3'-C(R-S-N·-C-OH)]. Biomimetic simulation reactions for the generation of the nitrogen-centered radicals similar to the one observed during the inactivation of the RNR by azionuclotides was investigated. The study included several modes: (i) theoretical calculation that showed the feasibility of the ring closure reaction between thiyl radicals and azido group; (ii) synthesis of the model azido nucleosides with a linker attached to C3' or C5' having a thiol or vicinal dithiol functionality; (iii) generation of the thiyl radical under both physiological and radiolysis conditions whose role is important in the initiation on RNR cascades; and (iv) analysis of the nitrogen-centered radical species formed during interaction between the thiyl radical and azido group by electron paramagnetic resonance spectroscopy (EPR). Characterization of the aminyl radical species formed during one electron attachment to the azido group of 2'-azido-2'-deoxyuridine and its stereospecifically labelled 1'-, 2'-, 3'-, 4'- or 5,6-[2H 2]-analogues was also examined. This dissertation gave insight toward understanding the mechanism of the formation of the nitrogen-centered radical during the inactivation of RNRs by azidonucleotides as well as the mechanism of action of RNRs that might provide key information necessary for the development of the next generation of antiviral and anticancer drugs.

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Abstract: The first metatarsal sesamoid bones are not always taken into consideration when making a diagnosis, in pathologies that affect the region of the first metatarsal head. This is due to the insufficient knowledge of all the pathologies that can affect the sesamoids and the relative little incidence that they have. With the increment of sports activities, in particular the running, increasingly affects of the symptoms concerning this region are observed. Methods: A literature search was performed in 5 databases (Medline, PubMed, Scopus, Cochrane Library and BUCEA). The terms included in the search were: sesamoids, anatomy, biomechanics, sesamoids review and sesamoids pathology. In the initial search articles with no more than 10 years, only humans and revision texts are considered. Results: 24 articles were selected and include different pathologies with diagnosis using imaging tests and treatments, both conservative and surgical; as well as aspects from the biomechanics of the metatarsal-sesamoid joint. Conclusion: Sesamoids due of his anatomy, topography and function can be involved in a lot of pathologies; with similar signs and symptoms that can confuse the podiatry when he has to make a correct diagnosis or treatment.

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Caption title.

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Özege, M.S. Eski harflerle,

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Mode of access: Internet.

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v. 1. Historical notice of the English power in Acquitaine. The battle of Poitiers. Historical notice of Peter the Cruel. The Black prince in Spain.--v. 2. Biographical notice of Froissart. The court of Gaston de Foix. Historical notice of the Companions. Aymergot Marcel. Historical notice of the border-feuds between England and Scotland. The battle of Otterbourne.--v. 3. Historical notice of the reign of Bajazet I. The seige of Nicopolis. Historical notice of the (second) house of Burgundy. The last days of Charles the Bold.

Second report drawn up on behalf of the Committee on Agriculture, Fisheries and Food. A. on the proposals from the Commission of the European Communities to the Council (COM(84) 515 final - Doc. 2-629/84) for: I. a regulation amending Regulation (EEC) No. 337/79 on the common organization of the market in wine; II. a regulation amending Regulation (EEC) No. 338/79 Laying down special provisions relating to quality wines produced in specified regions; III. a regulation introducing a derogation to the scheme provided for in Regulation (EEC) No. 456/80 on the granting of temporary and permanent abandonment premiums in respect of certain areas under vines and of premiums for the renunciation of replanting; IV. a regulation on the granting for the 1985/86-1989/90 wine years of permanent abandonment premiums in respect of certain areas under vines. B. on the amendment to the proposal from the Commission of the European Communities to the Council (COM(84) 539 final- Doc. 2-780/84) for a regulation amending Regulation (EEC) No. 337/79 on the common organization of the market in wine (COM(84) 515 final of 12.9.1984). C. on the proposals from the Commission of the European Communities to the Council (COM(84) 714 final - Doc. 2-1447/84) for: I. an amendment to the proposal for a regulation amending Regulation (EEC) No. 337/79 on the common organization of the market in wine (COM(84) 515 final and COM(84) 539 final); II. an amendment to the proposal for a regulation amending Regulation (EEC) No. 338/79 Laying down special provisions relating to quality wines produced in specified regions (COM(84) 515 final). D. on the proposal from the Commission of the European Communities to the Council (COM(84) 775 final - Doc. 2-1481/84) for a third amendment to the proposal for a regulation amending Regulation (EEC) No. 337/79 on the common organization of the market in wine. Working Documents 1984-85, Document 2-1575/84, 5 February 1985

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The unusual (1:1) complex ‘adduct’ salt of copper(II) with 4,5-dichlorophthalic acid (H2DCPA), having formula [Cu(H2O)4(C8H3Cl2O4) (C8H4Cl2O4)] . (C8H3Cl2O4) has been synthesized and characterized using single-crystal X-ray diffraction. Crystals are monoclinic, space group P21/c, with Z = 4 in a cell with dimensions a = 20.1376(7), b =12.8408(4) c = 12.1910(4) Å, β = 105.509(4)o. The complex is based on discrete tetragonally distorted octahedral [CuO6] coordination centres with the four water ligands occupying the square planar sites [Cu-O, 1.962(4)-1.987(4) Å] and the monodentate carboxyl-O donors of two DCPA ligand species in the axial sites. The first of these bonds [Cu-O, 2.341(4) Å] is with an oxygen of a HDCPA monoanion, the second with an oxygen of a H2DCPA acid species [Cu-O, 2.418(4) Å]. The un-coordinated ‘adduct’ molecule is a HDCPA counter anion which is strongly hydrogen-bonded to the coordinated H2DCPA ligand [O… O, 2.503(6) Å] while a number of peripheral intra- and intermolecular hydrogen-bonding interactions give a two-dimensional network structure.