Hon. Jonathan Russell's letter to John P. Van Ness, Esq.

James P. Van Ness was chairman of the Jackson Corresponding Committee of the District of Columbia.

The writings of the late John M. Mason, D.D. consisting of sermons, essays, and miscellanies, including essays already published in the "Christian magazine".

Mode of access: Internet.

The victorious Christian awaiting his crown : a discourse delivered on sabbath evening, January 3, 1830, occasioned by the death of Rev. John M. Mason ... /

NUC pre-1956

West Indies. Extracts from the journal of John Candler, whilst travelling in Jamaica. Part I-[II]

Mode of access: Internet.

Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose

High ambient glucose activates intracellular signaling pathways to induce the expression of extracellular matrix and cytokines such as connective tissue growth factor (CTGF). Cell responses to CTGF in already glucose-stressed cells may act to transform the mesangial cell phenotype leading to the development of glomerulosclerosis. We analyzed cell signaling downstream of CTGF in high glucose-stressed mesangial cells to model signaling in the diabetic milieu. The addition of CTGF to primary human mesangial cells activates cell migration which is associated with a PKC-zeta-GSK3beta signaling axis. In high ambient glucose basal PKC-zeta and GSK3beta phosphorylation levels are selectively increased and CTGF-stimulated PKC-zeta and GSK3beta phosphorylation was impaired. These effects were not induced by osmotic changes. CTGF-driven profibrotic cell signaling as determined by p42/44 MAPK and Akt phosphorylation was unaffected by high glucose. Nonresponsiveness of the PKC-zeta-GSK3beta signaling axis suppressed effective remodeling of the microtubule network necessary to support cell migration. However, interestingly the cells remain plastic: modulation of glucose-induced PKC-beta activity in human mesangial cells reversed some of the pathological effects of glucose damage in these cells. We show that inhibition of PKC-beta with LY379196 and PKC-beta siRNA reduced basal PKC-zeta and GSK3beta phosphorylation in human mesangial cells exposed to high glucose. CTGF stimulation under these conditions again resulted in PKC-zeta phosphorylation and human mesangial cell migration. Regulation of PKC-zeta by PKC-beta in this instance may establish PKC-zeta as a target for constraining the progression of mesangial cell dysfunction in the pathogenesis of diabetic nephropathy.

Estudios de historia colonial

Tabla de contenidos: Hombres, mujeres y honor : Injurias, calumnias y difamación en Buenos Aires [1770-1840]. Un aspecto de la mentalidad vigente / Silvia Mallo. Esos torpes dezeos : Delitos y desviaciones sexuales en Buenos Aires 1760-1810 / Osvaldo Barreneche. Las relaciones hispano-indígenas en la frontera bonaerense [1580-1630] / Susana Battista, Claudia Ríos.

A proof of Jesus Christ's being the ancient promised Messiah: a sermon preached in the Chapel of Harvard College at Cambridge in New England, June 23, 1756

The hand-sewn notebook contains a 24-page manuscript draft of the second Dudleian lecture, delivered by John Barnard on June 23, 1756. The copy includes a small number of edits and struck-out words adopted in the printed version published by J. Draper of Boston in 1756. The sermon begins with the Biblical text Mark 14:61, 62. The covers are no longer with the item.

A historical account of bills of mortality, and the probability of human life, in Glasgow and other large towns.

Mode of access: Internet.

Geographical education, report to the Council of the Royal Geographical Society,

Mode of access: Internet.

Confesión de Buonaparte con el Cardenal Mauri, dedicada al General Kleber /

Mode of access: Internet.

Letter to His Grace, the Duke of Hamilton and Brandon, respecting the parochial registers of Scotland.

Mode of access: Internet.

Charakter-Züge und historische Fragmente aus dem Leben des Königs von Preussen Friedrich Wilhelm III.

Mode of access: Internet.