Climate Change and Health: A platform for action

This paper provides an introduction to the links between climate change and health and aims to inform policy-makers, politicians and the public of the benefits for health from reducing greenhouse gas (GHG)* emissions from food production, transport, energy, and waste. It also highlights the importance of action by the health sector.It presents a platform for action which demonstrates that creating healthy sustainable places and communities can go hand in hand with reducing the negative impacts of climate change.

MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T.

Recently, the spin-echo full-intensity acquired localized (SPECIAL) spectroscopy technique was proposed to unite the advantages of short TEs on the order of milliseconds (ms) with full sensitivity and applied to in vivo rat brain. In the present study, SPECIAL was adapted and optimized for use on a clinical platform at 3T and 7T by combining interleaved water suppression (WS) and outer volume saturation (OVS), optimized sequence timing, and improved shimming using FASTMAP. High-quality single voxel spectra of human brain were acquired at TEs below or equal to 6 ms on a clinical 3T and 7T system for six volunteers. Narrow linewidths (6.6 +/- 0.6 Hz at 3T and 12.1 +/- 1.0 Hz at 7T for water) and the high signal-to-noise ratio (SNR) of the artifact-free spectra enabled the quantification of a neurochemical profile consisting of 18 metabolites with Cramér-Rao lower bounds (CRLBs) below 20% at both field strengths. The enhanced sensitivity and increased spectral resolution at 7T compared to 3T allowed a two-fold reduction in scan time, an increased precision of quantification for 12 metabolites, and the additional quantification of lactate with CRLB below 20%. Improved sensitivity at 7T was also demonstrated by a 1.7-fold increase in average SNR (= peak height/root mean square [RMS]-of-noise) per unit-time.

Lassa virus entry in antigen presenting cells and evaluation of a novel nanoparticle vaccine platform against arena viruses

Arenaviruses are a large and diverse family of viruses that merit significant attention as causative agents of severe hemorrhagic fevers in humans. Lassa virus (LASV) in Africa and the South American hemorrhagic fever viruses Junin (JUNV), Machupo (MACV), and Guanarito (GTOV) have emerged as important human pathogens and represent serious public health problems in their respective endemic areas. A hallmark of fatal arenaviruses hemorrhagic fevers is a marked immunosuppression of the infected patients. Antigen presenting cells (APCs) such as macrophages and in particular dendritic cells (DCs) are early and preferred targets of arenaviruses infection. Instead of being recognized and presented as foreign antigens by DCs, arenaviruses subvert the normal mechanisms of pathogen recognition, invade DCs and establish a productive infection. Viral replication perturbs the DCs' ability to present antigens and to activate T and B cells, contributing to the marked virus-induced immunosuppression observed in fatal disease. Considering their crucial role in the development of an anti-viral immune response, the mechanisms by which arenaviruses, and in particular LASV, invade DCs are of particular interest. The C-type lectin DC-specific Intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) was recently identified as a potential entry receptor for LASV. The first project of my thesis focused therefore on the investigation of the role of DC-SIGN in LASV entry into primary human DCs. My data revealed that DC-SIGN serves as an attachment factor for LASV on human DCs and can facilitate capture of free virus and subsequent cell entry. However, in contrast to other emerging viruses, of the phlebovirus family, I found that DC-SIGN does likely not function as an authentic entry receptor for LASV. Moreover, I was able to show that LASV enters DCs via an unusually slow pathway that depends on actin, but is independent of clathrin and dynamin. Considering the lack of effective treatments and the limited public health infrastructure in endemic regions, the development of protective vaccines against arenaviruses is an urgent need. To address this issue, the second project of my thesis aimed at the development of a novel recombinant arenavirus vaccine based on a nanoparticle (NPs) platform and its evaluation in a small animal model. During the first phase of the project I designed, produced, and characterized suitable vaccine antigens. In the second phase of the project, I generated antigen-conjugated NPs, developed vaccine formulations, and tested the NPs for their ability to elicit anti-viral T cell responses as well as anti-viral antibodies. I demonstrated that the NPs platform is able to activate both cellular and humoral branches of the adaptive anti-viral immunity, providing proof-of-principle. In sum, my first project will allow, in a long term perspective, a better understanding of the viral pathogenesis and contribute to the development of novel antiviral strategies. The second project will expectidly offer a new treatment option against arenaviruses.

EORTC Radiation Oncology Group quality assurance platform: establishment of a digital central review facility.

OBJECTIVE: Quality assurance (QA) in clinical trials is essential to ensure treatment is safely and effectively delivered. As QA requirements have increased in complexity in parallel with evolution of radiation therapy (RT) delivery, a need to facilitate digital data exchange emerged. Our objective is to present the platform developed for the integration and standardization of QART activities across all EORTC trials involving RT. METHODS: The following essential requirements were identified: secure and easy access without on-site software installation; integration within the existing EORTC clinical remote data capture system; and the ability to both customize the platform to specific studies and adapt to future needs. After retrospective testing within several clinical trials, the platform was introduced in phases to participating sites and QART study reviewers. RESULTS: The resulting QA platform, integrating RT analysis software installed at EORTC Headquarters, permits timely, secure, and fully digital central DICOM-RT based data review. Participating sites submit data through a standard secure upload webpage. Supplemental information is submitted in parallel through web-based forms. An internal quality check by the QART office verifies data consistency, formatting, and anonymization. QART reviewers have remote access through a terminal server. Reviewers evaluate submissions for protocol compliance through an online evaluation matrix. Comments are collected by the coordinating centre and institutions are informed of the results. CONCLUSIONS: This web-based central review platform facilitates rapid, extensive, and prospective QART review. This reduces the risk that trial outcomes are compromised through inadequate radiotherapy and facilitates correlation of results with clinical outcomes.

Aplicación web con tecnología Java para la gestión de competencias en los estudios de grado

El objetivo de este proyecto es desarrollar una aplicación web con tecnología Java como alternativa a PHP. La web consiste en facilitar la gestión de competencias de los estudios de los grados universitarios. Dentro de la aplicación tanto coordinadores como administradores podrán realizar asignaciones y mantenimiento de dichas competencias. Los usuarios no registrados podrán obtener información de las competencias a través de los estudios seleccionados. Concluye con una comparación de la tecnología usada con PHP sobre la aplicación, detallando las ventajas e inconvenientes de una frente a la otra.

Monitor de servidors JMS

El monitor de servidors JMS és un projecte basat en el disseny i implementacio d'una eina GUI, destinada a programadors i equips de proves que treballin amb la tecnología Java Message Service, multiplataforma i multiservidor, que podrà monitoritzar un nombre variat de servidors JMS des de qualsevol sistema que tingui una màquina virtual de Java instal·lada. L'aplicació té com a principal objectiu visualitzar de forma clara i senzilla l'estat global d'un servidor JMS, mostrant les cues i tòpics creats, juntament amb la possibilitat de realitzar accions sobre les mateixes destinacions (enviament i eliminació de missatges residents al servidor) i la creació de gràfiques sobre el tràfic de missatges.

Gestión y contabilización de facturas en formato Facturae

Este proyecto se inició con el objetivo de incluir una nueva funcionalidad en el módulo de Finanzas de ekon, el ERP que comercializa la empresa UNIT4. La nueva funcionalidad debía permitir registrar, visualizar y contabilizar facturas electrónicas. El entorno de desarrollo ha sido karat 8.0, la plataforma tecnológica que se utiliza en UNIT4 para añadir nuevas funcionalidades estándar a sus productos o personalizarlos para cada cliente. Dichas funcionalidades se codifican en Java, ya que es el lenguaje de programación en el que se ha desarrollado karat 8.0.

Creación de una web de gestión de álbumesfotográficos utilizando tecnología Java EE

El present treball de fi de carrera es planteja en base a l'anàlisi, planificació i desenvolupament d'una aplicació web basada en el model Java EE i que permetrà als usuaris del sistema la creació de col leccions digitals de fotografies.

La Botigueta de Vinils

Java 2 Plataform Enterprise J2EE, amb utilització de Spring Web, Hibernate, JavaServer Faces i ICEfaces.

Creació d'una eina en Java que a partir d'OWL i JESS generi SCORM

Aquest projecte consisteix en generar un programa escrit en llenguatge Java, que utilitzant un motor d'inferència a través d'una llibreria anomenada JESS, pugui llegir un document en format OWL que és una representació de l'ontologia (representació del coneixement) sobre una assignatura, transformant-lo al format de triples que és capaç d'interpretar JESS.

Anàlisi, disseny i implementació d'una pàgina web i de la gestió del seu contingut mitjançant Java/J2EE.

Els principals objectius del TFC ha estat l'anàlisi, disseny i implementació d'una web per a una empresa d'automoció i donar-li a l'empresa la capacitat de gestionar el contingut de la web, cosa que fins ara no podia fer. To això utilitzant la tecnologia Java i J2EE.

JWQ : Java WebQuest

L¿objectiu principal d¿aquest projecte és el de donar resposta a la necessitat de uncol·lectiu de professors i alumnes de magisteri de disposar d¿una eina de pràctiques per larealització de WebQuests.

Desarrollo para Internet con tecnología Java : Sistema de reservas para hoteles

En aquest projecte es presenta la creació d'un sistema de reserves per a hotels orientat a Internet que utilitza tecnologia Java. D'una manera especial, s'exposen les tecnologies J2EE, que es poden aplicar des de dos vessants diferents: en primer lloc, des del vessant d'implementació amb tecnologies J2EE, i, en segon lloc, des del vessant d'arquitectura J2EE, amb les diferents solucions aplicables per a cada capa de negoci.