Plasma free fatty acids do not provide the link between obesity and insulin resistance or β-cell dysfunction: results of the Reading, Imperial, Surrey, Cambridge, Kings (RISCK) study

Aims To investigate the relationship between adiposity and plasma free fatty acid levels and the influence of total plasma free fatty acid level on insulin sensitivity and β-cell function. Methods An insulin sensitivity index, acute insulin response to glucose and a disposition index, derived from i.v. glucose tolerance minimal model analysis and total fasting plasma free fatty acid levels were available for 533 participants in the Reading, Imperial, Surrey, Cambridge, Kings study. Bivariate correlations were made between insulin sensitivity index, acute insulin response to glucose and disposition index and both adiposity measures (BMI, waist circumference and body fat mass) and total plasma free fatty acid levels. Multivariate linear regression analysis was performed, controlling for age, sex, ethnicity and adiposity. Results After adjustment, all adiposity measures were inversely associated with insulin sensitivity index (BMI: β = −0.357; waist circumference: β = −0.380; body fat mass: β = −0.375) and disposition index (BMI: β = −0.215; waist circumference: β = −0.248; body fat mass: β = −0.221) and positively associated with acute insulin response to glucose [BMI: β = 0.200; waist circumference: β = 0.195; body fat mass β = 0.209 (P values <0.001)]. Adiposity explained 13, 4 and 5% of the variation in insulin sensitivity index, acute insulin response to glucose and disposition index, respectively. After adjustment, no adiposity measure was associated with free fatty acid level, but total plasma free fatty acid level was inversely associated with insulin sensitivity index (β = −0.133), acute insulin response to glucose (β = −0.148) and disposition index [β = −0.218 (P values <0.01)]. Plasma free fatty acid concentration accounted for 1.5, 2 and 4% of the variation in insulin sensitivity index, acute insulin response to glucose and disposition index, respectively. Conclusions Plasma free fatty acid levels have a modest negative association with insulin sensitivity, β-cell secretion and disposition index but no association with adiposity measures. It is unlikely that plasma free fatty acids are the primary mediators of obesity-related insulin resistance or β-cell dysfunction.

Frames and the interpreter in the Imperial War Museum photographic archive

Using Azoulay's frame of the civil gaze, this chapter examines selected Second World War images, catalogued under 'interpreter' in the IWM's photographic archive, looking at representative situations in which interpreters typically operate in wartime - communicating with clandestine forces, liaising between the army and civilians, and dealing with the aftermath of war.

Mineralogical and microthermometric studies and structural aspects of imperial topaz mineralization in Antonio Pereira, Ouro Preto District (Minas Gerais) - Brazil

The occurrences of imperial topaz in the Antonio Pereira mine, Ouro Preto, Minas Gerais, are associated with the metamorphic carbonate rocks of the Minas Supergroup. The crystals have densities varying from 3.46 to 3.58. The parameters of the unitary cells obtained were: 4.658 to 4.663 angstrom (ao), 8.823 to 8.832 angstrom (b(o)), 8.382 to 8.389 angstrom (c(o)), and 344.65 to 345.46 angstrom 3 (V). The refraction indices presented the following variations: 1.622 to 1.630 (nX), 1.624 to 1.632 (nY), 1.633 to 1.640 (nZ), and 0.008 to 0.011 (B). These properties are coherent with the low fluorine contents obtained (16,48%/17,05wt%). Infrared spectroscopy and microthermometry showed that the fluid inclusions, which represent the mineralizing fluids, are formed by H(2)O (with Ca(2+), Mg(2+) and Na(+)), and CO(2) +/- CH(4). The minimal trapping T-P conditions of 290/320 degrees C and 2,349/2,497bar were obtained for the primary fluid inclusions. The pseudo-secondary fluid inclusions were trapped at conditions of lower temperatures and variable pressures, during the deformation process under local alternating states of stress. The microthermometric studies, the structural analysis and the fluorine contents suggest that the mineralized veins were formed from hydrothermal fluids originated during the Brasiliano tectono-metamorphic event.

Peopling of the Northern Territory part 1: a white elephant in a white Australia? The Northern Territory, 1901-1920

As a result of negative net immigration during the 1890s depression, Australians at the time of Federation were preoccupied about the slow rate of growth of the population. The non-Aboriginal population at the end of 1904 was approximately three and three-quarter million. and the publication in March 1904 of the Report of the New South Wales Royal Commission on the Decline of the Birth Rate and the Mortality of Infants did nothing to allay these concerns. Despite the perceived need for more people. the desire for racial unity was paramount. The main goals of policy makers at the time were to preserve a 'white' and essentially British Australia and create an imperial bastion in the Southern Hemisphere.

Cannabilsm and imperial violence in Furphy`s The Buln-buln and the Brolga : metafiction and the national conference

Book review

The square from inside out: Federation Square, Melbourne

This XXlst Annual Conference of SAHANZ offers a timely opportunity for celebrating and critically reflecting on Federation Square, Melbourne - a project that continually crosses the line between the purely experimental and the built form (A Benjamin, 2003) and offers an opportunity to identify and investigate the different, often competing, limits within the discipline of architecture. Here in this project, considered by the city of Melbourne to point to its future aspirations; and by the RAIA as demonstrating 'the strength of design and the leap into the unknown which is where good design always comes from' (I McDougall, 2003), different approaches to the possibilities of 'limit' as a contemporary concern can be fruitfully explored. Architectural masterpieces are daringly imaginative and each in their own way challenges architects, engineers, builders and technologists - those who are to realise the dream - and makes administrators, politicians and governments put their credibility on the line. So how does Federation Square contribute to contemporary architectural debate, specifically to Melbourne architecture? How has it dealt with thresholds? Where has It approached, crossed and/or exceeded boundaries? This paper will deal with design aesthetics in the realisation of the Lab architects 'vision' in the context of historical, urban and political realities. Analysis will provide insights into the limitations imposed upon this architectural project and the limitations it now, in turn, imposes on the city. Two aspects will be dealt with: understanding Lab's overall vision, and juxtaposing the vision with the reality of Federation Square. The author's interview with Don Bates, principal Lab architecture studio, forms the frame argument about Federation Square in this paper.

A new nation : members of the Federation Conference recently held at Melbourne, Australia

The delegates are numbered and their names listed below the print: 1.M'Millan, 2.A. Inglis Clarke, 3.Sir John Hall, 4.Captain Russell, 5.Macrossan, 6.Sir Samuel Griffith, 7.Sir Henry Parkes, 8.Playford, 9.Premier Gillies, 10.Deakin, 11.Dr. Cockburn, 12.B.S. Bird, 13.Sir J. Lee Steere, 14. Secretary Jenkins.

Australian citizenship and the two World Wars

This article surveys Australian citizenship: its distinctive characteristics in the first half of the twentieth century, and how these were changed by the experience of the two world wars. It argues that Australian citizenship, at the time of Federation, was racially exclusive, imperial, masculine and deeply anchored in the traditional view of the military obligation of the individual to the state. The world wars, especially the war of 1939-45, encouraged some adjustment to these ideas, particularly in terms of the imperial link, women's status and the social rights of Australians. However, these conflicts were fought within a context of imperial loyalty and the intensity of their demands reinforced military service in defence of the nation as the primary civic virtue. The centrality of Anzac to Australian nationalism also perpetuated a gendered dimension to Australian citizenship. The world wars therefore, for all their dramatic impact on the lives of Australian families and the national political culture, did not force a major reconceptualisation of Australian citizenship.

Imperial shoe palace: a collection of poems

Poems