1927-1929, 1937-1938: William B. Jason

8th President 1927-19291937-1938 (Acting President)

Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions

Compelling evidence has accumulated over the last several years from our laboratory, as well as others, indicating that central hyperactive states resulting from neuronal plastic changes within the spinal cord play a critical role in hyperalgesia associated with nerve injury and inflammation. In our laboratory, chronic constriction injury of the common sciatic nerve, a rat model of neuropathic pain, has been shown to result in activation of central nervous system excitatory amino acid receptors and subsequent intracellular cascades including protein kinase C translocation and activation, nitric oxide production, and nitric oxide-activated poly(ADP ribose) synthetase activation. Similar cellular mechanisms also have been implicated in the development of tolerance to the analgesic effects of morphine. A recently observed phenomenon, the development of “dark neurons,” is associated with both chronic constriction injury and morphine tolerance. A site of action involved in both hyperalgesia and morphine tolerance is in the superficial laminae of the spinal cord dorsal horn. These observations suggest that hyperalgesia and morphine tolerance may be interrelated at the level of the superficial laminae of the dorsal horn by common neural substrates that interact at the level of excitatory amino acid receptor activation and subsequent intracellular events. The demonstration of interrelationships between neural mechanisms underlying hyperalgesia and morphine tolerance may lead to a better understanding of the neurobiology of these two phenomena in particular and pain in general. This knowledge may also provide a scientific basis for improved pain management with opiate analgesics.

[Letter from Jason Haven to the Corporation of Harvard College], 1780 July 15

Handwritten letter from Jason Haven requesting the Corporation to grant Draper a degree.

Mission scientifique du cap Horn, 1882-1883.

t.6:ptie.3:pt.2 (1888)

The European Union’s Response to Piracy: Are the Lessons Learned in the Horn of Africa a Model for the Gulf of Guinea? EU Diplomacy Paper/2015

The European Union (EU) is seen as the leading actor in successfully fighting piracy around the Horn of Africa. As a global trade power with strong economic interests, the EU is also challenged by similar maritime security threats in the Gulf of Guinea. To date, there has been no comprehensive analysis to assess the potential transfer of successful EU instruments from the Horn of Africa to the piracy situation in West African waters. This paper examines to what extent the EU can draw on its experience made in the Horn of Africa to deter piracy in West African waters. Based on qualitative research interviews, lessons learned from East Africa are identified and subsequently applied to the situation in the Gulf of Guinea. The results show that the EU is only partially drawing on its experience made in the Horn of Africa. One the one hand, it is rather reluctant to use crisis management instruments such as naval operations. On the other hand, the EU is drawing on its successful leadership in international political and military cooperation from around the Horn of Africa in order to make more effective use of available resources in the Gulf of Guinea.

Driver Aggression as a Function of Status Concurrence: An Analysis of Horn-Honking Responses

Various field experiments were conducted to examine the influence of social status on aggression in road traffic. Horn-honking response times of subjects blocked by an experimental car at traffic lights were considered to be an indicator of the degree of aggression. During an initial experiment, the status of the frustrator was varied and an inverse relation was observed between status and aggression towards the frustrator. On the other hand, in a more recent experiment higher status aggressors were found to behave more aggressively. In our study we combined the two designs, i.e., we varied the status of the frustrator and at the same time measured the status of the aggressor. Neither results of the former experiments could be replicated, but we observed a reduction in aggression when frustrator and aggressor were of similar social status.

1991 University of Michigan Football Team