Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

We have discovered that three longevity mutants of the nematode Caenorhabditis elegans also exhibit increased intrinsic thermotolerance (Itt) as young adults. Mutation of the age-1 gene causes not only 65% longer life expectancy but also Itt. The Itt phenotype cosegregates with age-1. Long-lived spe-26 and daf-2 mutants also exhibit Itt. We investigated the relationship between increased thermotolerance and increased life-span by developing conditions for environmental induction of thermotolerance. Such pretreatments at sublethal temperatures induce significant increases in thermotolerance and small but statistically highly significant increases in life expectancy, consistent with a causal connection between these two traits. Thus, when an animal's resistance to stress is increased, by either genetic or environmental manipulation, we also observe an increase in life expectancy. These results suggest that ability to respond to stress limits the life expectancy of C. elegans and might do so in other metazoa as well.

Life-span, T-cell responses, and incidence of lymphomas in congenic mice.

Survival, T-cell functions, and postmortem histopathology were studied in H-2 congenic strains of mice bearing H-2b, H-2k, and H-2d haplotypes. Males lived longer than females in all homozygous and heterozygous combinations except for H-2d homozygotes, which showed no differences between males and females. Association of heterozygosity with longer survival was observed only with H-2b/H-2b and H-2b/H-2d mice. Analysis using classification and regression trees (CART) showed that both males and females of H-2b homozygous and H-2k/H-2b mice had the shortest life-span of the strains studied. In histopathological analyses, lymphomas were noted to be more frequent in females, while hemangiosarcomas and hepatomas were more frequent in males. Lymphomas appeared earlier than hepatomas or hemangiosarcomas. The incidence of lymphomas was associated with the H-2 haplotype--e.g., H-2b homozygous mice had more lymphomas than did mice of the H-2d haplotype. More vigorous T-cell function was maintained with age (27 months) in H-2d, H-2b/H-2d, and H-2d/H-2k mice as compared with H-2b, H-2k, and H-2b/H-2k mice, which showed a decline of T-cell responses with age.

White and Negro spirituals, their life span and kinship, tracing 200 years of untrammeled song making and singing among our country folk, with 116 songs as sung by both races.

"The tune comparative list. One hundred and sixteen melodies of white people paired with same number of Negro-sung variants": p. [145]-227.

National five digit zip code and post office directory /

Kept up to date by addenda.

Implementation of basic software for significant digit arithmetic.

Thesis (M.A.)--University of Illinois at Urbana-Champaign.

The span of life, as influenced by the heart, the kidneys and the blood vessels,

A summary of lectures given at the Santa Barbara cottage hospital. cf. Introd

Comparison of 5th digit morphology behavior coding to stage of disease coding in the reporting of primary brain tumors.

At head of title: Illinois State Cancer Registry.

Life-span services : a handbook of Illinois state government agencies serving persons with developmental disabilities.

"Life span brochure."--Introd.

Operator's, organizational, direct support, and general support maintenance manual : bridge, armored-vehicle-launched, scissoring type, aluminum, 60-ft. span, for use with M-48 and M-60 launcher (all makes and models), FSN 5420-522-9599).

"October 1972."

Ten years of insured employment in Utah. Chart series, 1937 to 1946, 2 and 3 digit basis.

Mode of access: Internet.

Ten years of insured employment in Utah. Payroll and employment series, 1937 to 1946, 2 digit basis.

Mode of access: Internet.