Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways.

Peroxisome proliferators cause rapid and coordinated transcriptional activation of genes encoding peroxisomal beta-oxidation system enzymes by activating peroxisome proliferator-activated receptor (PPAR) isoform(s). Since the thyroid hormone (T3; 3,3',5-triiodothyronine) receptor (TR), another member of the nuclear hormone receptor superfamily, regulates a subset of fatty acid metabolism genes shared with PPAR, we examined the possibility of interplay between peroxisome proliferator and T3 signaling pathways. T3 inhibited ciprofibrate-induced luciferase activity as well as the endogenous peroxisomal beta-oxidation enzymes in transgenic mice carrying a 3.2-kb 5'-flanking region of the rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase gene fused to the coding region of luciferase. Transfection assays in hepatoma H4-II-E-C3 and CV-1 cells indicated that this inhibition is mediated by TR in a ligand-dependent fashion. Gel shift assays revealed that modulation of PPAR action by TR occurs through titration of limiting amounts of retinoid X receptor (RXR) required for PPAR activation. Increasing amounts of RXR partially reversed the inhibition in a reciprocal manner; PPAR also inhibited TR activation. Results with heterodimerization-deficient TR and PPAR mutants further confirmed that interaction between PPAR and TR signaling systems is indirect. These results suggest that a convergence of the peroxisome proliferator and T3 signaling pathways occurs through their common interaction with the heterodimeric partner RXR.

Middle to Late Quaternary sedimentation and rock-magnetic of ODP Site 105-646

We examine rock-magnetic, carbonate, and planktonic foraminiferal fluxes to identify climatically controlled changes of terrigenous and pelagic sedimentation at Ocean Drilling Program (ODP) Site 646 (the Labrador Sea). Terrigenous sediments are brought to the site principally by bottom currents. We use a rock-magnetic parameter sensitive to changes in magnetic mineral grain size, the ratio of anhysteretic susceptibility to low-field magnetic susceptibility (XARM/X), to monitor changes in bottom-current intensity over time, with large values of XARM/X (finer-grained magnetic minerals) indicating weaker bottom currents. A second rock-magnetic parameter, magnetic mineral accumulation rate (KaT) was used to indicate variations in terrigenous flux. Planktonic foraminiferal and carbonate accumulation rates (Pfar and CaC03ar) are used as indicators of pelagic flux. Absolute age assignments are based on correlation between the planktonic foraminiferal oxygen-isotope variations for Site 646 and the SPECMAP master oxygen-isotope curve. Cross-correlation analyses of the parameters that we studied with respect to the SPECMAP curve suggest that from oxygen-isotope stages 21 to 11, sedimentation rate, KaT, X, CaCO3ar, and Pfar were at their maximums, whereas XARM/X was at its minimum during peak interglacials (i.e., 0 k.y. lag time with respect to minimum ice volume). However, all parameters we examined lag behind minimum ice volume from stages 11 to 1, indicating a change in timing of both pelagic and terrigenous fluxes at approximately 400 k.y. BP. The negative correlation coefficient between XARM/X and the SPECMAP curve further suggest that finer-grained magnetic minerals are deposited during glacial periods, which probably reflects weaker bottom currents. The shift observed in the lag times of parameters examined with respect to the SPECMAP record is attributed to a change in significance of orbital parameters. Spectral results exhibit strong power in eccentricity (about 100 k.y.) throughout the record. Kap X, CaCO3flr, and Pfar show significant power in obliquity (about 41 k.y.), whereas XARM/X shows significant power at 73 k.y. from stages 21 to 11. The 73-k.y. period in XARM/X is near the difference tone of obliquity and eccentricity: 1/43-1/102 = 1/69. Kar and XARM/X show power only in eccentricity from stages 11 to 1. X and Pfar show significant power in precession (about 18 and 22 k.y.) whereas CaC03ar has power at 34 k.y, which could be a combination of precession and obliquity. The shift in power of orbital parameters may by attributed to the effect of the about 413-k.y. signal of eccentricity.

Report to the President by the Emergency Board ... to investigate and report in respect to the dispute between the Duluth, Missabe & Iron Range Railway Co., Chicago & North Western Railway, Great Northern Railway, Minneapolis, St. Paul & Sault Ste. Marie Railway, and certain of their employees as represented by the Brotherhood of Railway and Steamship Clerks, Freight Handlers, Express, and Station Employees.

Cover title.

Report to the President by the Emergency Board created August 26, 1948 by Executive order 9991 pursuant to section 10 of the Railway labor act, to investigate a dispute between the Pittsburgh and West Virginia Railway Company and certain of its employees represented by the Brotherhood of Railroad Trainmen. Pittsburgh, Pa. Sept. 13, 1948. No. 64.

Signed: John W. Yeager, chairman, John T. McCann, Thomas J. Reynolds.

The articles treated on in Tract 90 reconsidered : and their interpretation vindicated in a letter to the Rev. R.W. Jelf ; with an appendix from Abp. Ussher on the difference between ancient and modern addresses to saints /

Tract no. 90, by J.H. Newman, has title, Remarks on certain passages in the Thirty-nine articles.

The vinter's, brewer's, spirit merchant's, and licensed victualler's guide; containing the history, theory, and practice of manufacturing wines, foreign and domestic ... Numerous important hints on cellaring ... Also, a description of the saccharometer, and the various hydrometers, with their uses. Tables shewing the difference in quantity and value between the old and new imperial measures. Selections from, and abstracts of, all Acts of Parliament relating to excise laws.

Mode of access: Internet.

On the difference between physical and moral law /

Mode of access: Internet.

General agreement between Employee Service and Records Division, Bureau of Retirement, Insurance and Occupational Health, U.S. Civil Service Commission and American Federation of Government Employees Local 2450.

Mode of access: Internet.

A discourse on some points of difference between the sheriff's office in Massachusetts and in England. Read in the hearing of a number of the gentlemen of the bar ...

Title page and half-title not included in paging.

Report to the President by Emergency Board No. 236 : submitted pursuant to Executive Order no. 13248 dated December 20, 2001 and section 10 of the Railway Labor Act, as amended : investigation of disputes between United Airlines, Inc. and its employees represented by the International Association of Machinists and Aerospace Workers, District Lodge 141-LM : (National Mediation Board Case no. A-13109).

"January 19, 2002."

Arbitration between carriers and employees. Boards of adjustment. Hearings before a subcommittee of the Committee on interstate commerce, United States Senate, Sixty-eighth Congress, first session, on S. 2646, a bill to provide for the expeditious and prompt settlement, mediation, concilation, and arbitration of disputes between carriers and their employees and subordinate officials, and for other purposes. March 18, 28, 29, April 4, and 7, 1924 ...

Mode of access: Internet.

Some of the points of difference between Unitarian and orthodox Christians /

Mode of access: Internet.

Railroad claims (Statute of limitations) Hearing before a subcommittee of the Committee on Interstate and Foreign Commerce, House of Representatives, Seventy-first Congress, third session, on S. 571 and H.R. 3500, to amend section 204 of the act entitled "An act to provide for the termination of federal control of railroads and systems of transportation; to provide for the settlement of disputes between carriers and their employees; to further amend an act entitled 'An act to regulate commerce,' approved February 4, 1887, as amended, and for other purposes," approved February 28, 1920. February 23, 1931 ...

Carl E. Mapess, chairman of subcommittee.