Determinação do íon ferro em preparações farmacêuticas através da cromatografia planar e espectrofotometria

Os autores estudaram o comportamento cromatográfico de preparações farmacêuticas comerciais contendo o íon Fe (II). Utilizando celulose microcristalina/Propanol: ácido clorídrico 4 N: ácido acético concentrado: ácido nítrico concentrado: clorofórmio (40: 5: 5: 10: 10), como sistema cromatográfico e alizarina como reagente de detecção, Fe (II), Mn (II), Mg (II), Cu (II), Zn (II) e Ca (II) foram separados e identificados pela Cromatografia Planar. O Fe (II) foi determinado pela reação com a ortofenantrolina, resultando em solução adequada para quantificação colorimétrica.

Determinação de fármacos diuréticos em associação por cromatografia em camada delgada e espectrofotometria

A rapid, sensitive and reliable thin-layer chromatography/spectrophotometry screening procedure was developed for quantitative determination of diuretics associated in pharmaceutical dosage forms. The chromatographic method employed microcrystalline cellulose and butanol : acetic acid : water (4:1:1) or amilic alcohol : ammonium hydroxide 25% (9:1) as mobile phases and detection by U.V. light. The drugs were extracted using a simple procedure and were quantified by U.V. spectrophotometry. Results varied from 97.5 to 102.5% and are similar to those obtained by conventional methods. This method of quantification of diuretics is promising for quality control of drugs.

Cellular damages in the Allium cepa test system, caused by BTEX mixture prior and after biodegradation process

Petroleum and derivatives have been considered one of the main environmental contaminants. Among petroleum derivatives, the volatile organic compounds benzene, toluene, ethylbenzene and xylene (BTEX) represent a major concern due to their toxicity and easy accumulation in groundwater. Biodegradation methods seem to be suitable tools for the clean-up of BTEX contaminants from groundwater. Genotoxic and mutagenic potential of BTEX prior and after biodegradation process was evaluated through analyses of chromosomal aberrations and MN test in meristematic and F 1 root cells using the Allium cepa test system. Seeds of A. cepa were germinated into five concentrations of BTEX, non-biodegraded and biodegraded, in ultra-pure water (negative control), in MMS 4×10 -4M (positive control) and in culture medium used in the biodegradation (blank biodegradation control). Results showed a significant frequency of both chromosomal and nuclear aberrations. The micronucleus (MN) frequency in meristematic cells was significant for most of tested samples. However, MN was not present in significant levels in the F 1 cells, suggesting that there was no permanent damage for the meristematic cell. The BTEX effects were significantly reduced in the biodegraded samples when compared to the respective non-biodegraded concentrations. Therefore, in this study, the biodegradation process showed to be a reliable and effective alternative to treat BTEX-contaminated waters. Based on our results and available data, the BTEX toxicity could also be related to a synergistic effect of its compounds. © 2011 Elsevier Ltd.

Application of micronucleus test and comet assay to evaluate BTEX biodegradation

The BTEX (benzene, toluene, ethylbenzene and xylene) mixture is an environmental pollutant that has a high potential to contaminate water resources, especially groundwater. The bioremediation process by microorganisms has often been used as a tool for removing BTEX from contaminated sites. The application of biological assays is useful in evaluating the efficiency of bioremediation processes, besides identifying the toxicity of the original contaminants. It also allows identifying the effects of possible metabolites formed during the biodegradation process on test organisms. In this study, we evaluated the genotoxic and mutagenic potential of five different BTEX concentrations in rat hepatoma tissue culture (HTC) cells, using comet and micronucleus assays, before and after biodegradation. A mutagenic effect was observed for the highest concentration tested and for its respective non-biodegraded concentration. Genotoxicity was significant for all non-biodegraded concentrations and not significant for the biodegraded ones. According to our results, we can state that BTEX is mutagenic at concentrations close to its water solubility, and genotoxic even at lower concentrations, differing from some described results reported for the mixture components, when tested individually. Our results suggest a synergistic effect for the mixture and that the biodegradation process is a safe and efficient methodology to be applied at BTEX-contaminated sites. © 2012 Elsevier Ltd.

Avaliação dos efeitos citotóxicos, genotóxicos e mutagênicos do BTEX, antes e após o processo de biorremediação por microrganismos, utilizando os sistemas teste de Allium cepa e cultura de células de mamífero

Pós-graduação em Ciências Biológicas (Biologia Celular e Molecular) - IBRC

Avaliação da viabilidade do lodo de esgosto como recondicionante de solos agrícolas, após processo de atenuação natural, por meio de diferentes bioensaios

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O Brasil na historiografia inglesa dos anos joaninos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Discurso, resistência e identidade: o rock brasileiro dos anos 1980

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Historiografia literária e formação do cânone: Ana Miranda, Augusto dos Anjos e Olavo Bilac

Pós-graduação em Letras - IBILCE

Desenvolvimento da malha urbana de Guaratinguetá e propostas de intervenção

The work consists of the historical city of Guaratinguetá, as well as data on their quality of life, economic development and population, transportation in Brazil and the transportation system of the city serving as a basis to support the development of the urban network. The urban fabric of the city was raised with plants of the city in different years, documents obtained by the Museum and Hall of Frei Galvão Guaratinguetá well to check the form of land use and growth drivers of the city over time. We studied also the main access roads to the city by focusing on an approach that has been the subject of a proposed urban intervention. A direct interview was performed and recorded with one of those responsible for planning the urban fabric of the city in order to gather information on the historical development, the future possibilities of interventions in the urban as well as problems encountered and other curiosities. Through the study it was observed that the urban grid Guaratinguetá developing a planned since 1970 and that the highlights of most cities in the Paraíba Valley. The work is grounded in concepts of sustainable city and also in quantitative and qualitative data from sectors responsible

Intervenção midiática e a cobertura dos Jogos Olímpicos de Pequim/2008: subsídios para a difusão do atletismo

Como todo fenômeno de massa, os acontecimentos esportivos são, atualmente, um dos preferidos da mídia, sobretudo por questões de ordem mercadológica ou simbólica, já que o esporte tem papel fundamental na construção de identidades e subjetividades. Tendo como base este fato, o objetivo desta pesquisa consistiu em identificar como a mídia esportiva refere-se ao atletismo, quando da veiculação de reportagens jornalísticas. Para tanto, foram coletadas reportagens do jornal “Folha de São Paulo”, mais especificamente, do caderno “Pequim/2008” num período de 15 dias antes dos Jogos Olímpicos de Pequim/2008, durante o seu desenvolvimento e 15 dias após o término desse evento, isto é, de 22/07/2008 a 08/09/2008. Nesse período, foram coletadas 49 edições desse jornal, nas quais analisamos 88 reportagens relacionadas ao atletismo. Em revisão bibliográfica e com base na Análise de Conteúdo foram identificadas as principais características dessas reportagens, além dos temas mais recorrentes (unidades de registro) e o contexto (unidades de contexto) de cada uma delas. Foram criados 5 blocos de categorias, a saber: 1. Breves notas informativas sobre o atletismo; 2. Curiosidades acerca do atletismo mundial; 3. Resultados obtidos nas provas do atletismo; 4. Preparação dos atletas e expectativa em relação ao desempenho e 5. Destaques do atletismo nos Jogos Olímpicos de Pequim. A descrição de cada um dos blocos de categorias favoreceu a exposição dos resultados, dentre os quais: a falta de informação que é dedicada ao atletismo pela mídia em períodos em que não ocorrem grandes competições esportivas, a ênfase dada por ela por ocasião de eventos de repercussão internacional e a atenção especial voltada aos atletas que estão no auge da carreira e que, de alguma forma, passam a ser reconhecidos...(Resumo completo, clicar acesso eletrônico abaixo)

Artista/Câmara de maravilhas

Pós-graduação em Artes - IA

Escoamento da produção de café: uma projeção de logística

This paper seeks to show which impacts there are of the combined use of different modal for the coffee’s outflow. Nowadays is used, almost exclusively, the roadway to transport. How-ever, for this product with low added value, the types of transports best suited, in the litera-ture, are the railway and waterway. For this, is describe the development and spread of coffee throughout Brazil. Subsequently, is calculate the current cost of transporting two producing regions (Minas Gerais and Rondônia), using for that information about the freight, the social cost, and the level of losses along the way. After that is projected costs if utilizes the multi-modal model, when considering the same cost parameters used for the current model. Here-after, an analysis is made of the obtained cost, speed, consistency, capacity, availability and frequency of each transport model. Therefore, note that the multi-modal system is more ef-ficient and economical than current, based on transport by road

Sexualidade e deficiencias: dando vozes aos adolescentes por meio de oficinas pedagógicas

Pós-graduação em Educação Sexual - FCLAR

Artes orientais de movimentos: alternativas às terapias do campo da saúde. uma possibilidade de investigação para a psicologia do esporte. um exemplo de pesquisa fenomenológica

This research analyzes the discourse of teachers of ancient oriental arts, namely: Yoga, Tai Chi Chuan, Kung Fu, Lian Gong, Qwan Ki Do, reveals the meaning that subjects have about what are the benefits to health of those already considered practical alternatives conventional treatment of health. The research uses the phenomenological method specifically the method of the phenomenon. The method first provides a pre-reflection on the oriental arts, exposing not systematically, some curiosities changing between aspects of oriental arts: historical, main teaching methods, styles, the character of struggle, why are linked to health, the benefits of their practices, movements, philosophy, concepts, ways of acting, the roots, the basics. In this article the pre-reflection does not appear to meet the standards of Congress page limit. Rather concentrate on the next step of the research and present the phenomenon situated in the experience of those who have experienced it in the case of the five arts teachers mentioned above. The method performs individual analysis or ideographic analysis of the five discourses of teachers from each oriental art and then conducts the general or nomothetic. The result is presented an analysis of generalities, convergence, divergence and individuality of meanings expressed by the subject, to finally develop a discussion of these data and weave a synthesis. The analyzes reveal that Eastern practices currently as some of these five analyzed here, those involving aspects of struggle and concentration are excellent allied health development and well-being. Understanding the philosophical aspect is inherent in the practice of the movements, although the character of the struggle, which they transmit through knowledge of their origins and roots is the current thinking routine that generates a life philosophy of selfhelp, self-enabling and tranquility preparation to overcome the tensions, disputes, everyday challenges. The speeches also reveal that the psychophysical aspects of diseases are real, because the practices of movements and the physical drilling of these oriental arts have enabled visible improvements in health by working the mental and the physical in an integrated manner. Masters must have all the knowledge to better meet today's society, preserving these cultures, passing them through the generations.