Manipulation of the periovulatory sex steroidal milieu affects endometrial but not luteal gene expression in early diestrus Nelore cows

In beef cattle, the ability to conceive has been associated positively with size of the preovulatory follicle (POF). Proestrus estradiol and subsequent progesterone concentrations can regulate the endometrium to affect receptivity and fertility. The aim of the present study was to verify the effect of the size of the POF on luteal and endometrial gene expression during subsequent early diestrus in beef cattle. Eighty-three multiparous, nonlactating, presynchronized Nelore cows received a progesterone-releasing device and estradiol benzoate on Day–10 (D 10). Animals received cloprostenol (large follicle-large CL group; LF-LCL; N ¼ 42) or not (small follicle-small CL group; SF-SCL; N ¼ 41) on D 10. Progesterone devices were withdrawn and cloprostenol administered 42 to 60 hours (LF-LCL) or 30 to 36 hours (SF-SCL) before GnRH treatment (D0). Tissues were collected at slaughter on D7. The LF-LCL group had larger (P < 0.0001) POF (13.24 0.33 mm vs. 10.76 0.29 mm), greater (P < 0.0007) estradiol concentrations on D0 (2.94 0.28 pg/mL vs. 1.27 0.20 pg/mL), and greater (P < 0.01) progesterone concentrations on D7 (3.71 0.25 ng/mL vs. 2.62 0.26 ng/mL) compared with the SF-SCL group. Luteal gene expression of vascular endothelial growth factor A, kinase insert domain receptor, fms-related tyrosine kinase 1, steroidogenic acute regulatory protein, cytochrome P450, family 11, subfamily A, polypeptide 1, and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid deltaisomerase 7 was similar between groups. Endometrial gene expression of oxytocin receptor and peptidase inhibitor 3, skin-derived was reduced, and estrogen receptor alpha 2, aldo-keto reductase family 1, member C4, and lipoprotein lipase expression was increased in LF-LCL versus SF-SCL. Results support the hypothesis that the size of the POF alters the periovulatory endocrine milieu (i.e., proestrus estradiol and diestrus progesterone concentrations) and acts on the uterus to alter endometrial gene expression. It is proposed that the uterine environment and receptivity might also be modulated. Additionally, it is suggested that increased progesterone secretion of cows ovulating larger follicles is likely due to increased CL size rather than increased luteal expression of steroidogenic genes.

Making Research Relevant to Development - Experience from the NCCR North-South

Making research relevant to development is a complex, non-linear and often unpredictable process which requires very particular skills and strategies on the part of researchers. The National Centre of Competence in Research (NCCR) North-South provides financial and technical support for researchers so that they can effectively cooperate with policy-makers and practitioners. An analysis of 10 years of experience translating research into development practise in the NCCR North-South revealed the following four strategies as particularly relevant: a) research orientation towards the needs and interests of partners; b) implementation of promising methods and approaches; c) communication and dissemination of research results; and d) careful analysis of the political context through monitoring and learning approaches. The NCCR North-South experience shows that “doing excellent research” is just one piece of the mosaic. It is equally important to join hands with non-academic partners from the very beginning of a research project, in order to develop and test new pathways for sustainable development. Capacity building – in the North and South – enables researchers to do both: To do excellent research and to make it relevant for development.

Capacity Building in the Use of Geospatial Tools for Natural Resource Management in Tajikistan: Inception report

The sustainable management of natural resources is a key issue for sustainable development of a poor, mountainous country such as Tajikistan. In order to strengthen its agricultural and infrastructural development efforts and alleviate poverty in rural areas, spatial information and analysis are of crucial importance to improve priority setting and decision making efficiency. However, poor access to geospatial data and tools, and limited capacity in their use has greatly constrained the ability of governmental institutions to effectively assess, plan, and monitor natural resources management. The Centre for Development and Environment (CDE) has thus been mandated by the World Bank Group to provide adequate technical support to the Community Agriculture and Watershed Management Project (CAWMP). This support consists of a spatial database on soil degradation trends in 4 watersheds, capacity development in and awareness creation about geographic information technology and a spatial data exchange hub for natural resources management in Tajikistan. CDE’s support has started in July 2007 and will last until December 2007 with a possible extension in 2008.

Analysing factors determining the adoption of environmental management measures on the highlands of Ethiopia

A study was conducted on the highlands of Ethiopia to identify and analyse the factors determining the adoption of environmental management measures. In 1985, Ethiopia was classified into low –and high-potential areas based on the suitability of the natural environment for rain-fed agriculture. To address these objectives, case study areas were selected from low-potential and high-potential areas randomly. Data were collected through face-to-face interview and key informants, focus group discussion and field observation. In the low-potential areas, the physical environment ‒ particularly soil and forest environments have shown substantial recovery. Similarly, the water environment has improved. However, in the high-potential areas sampled, these resources are still being degraded. Clear understanding of the benefits of soil conservation structures by farmers, active involvement and technical support from the government and full and genuine participation of farmers in communal environmental resources management activities were found to be main factors in the adoption of environmental management measures.

Developing a point-of-care electronic medical record system for TB/HIV co-infected patients: experiences from Lighthouse Trust, Lilongwe, Malawi.

BACKGROUND Implementation of user-friendly, real-time, electronic medical records for patient management may lead to improved adherence to clinical guidelines and improved quality of patient care. We detail the systematic, iterative process that implementation partners, Lighthouse clinic and Baobab Health Trust, employed to develop and implement a point-of-care electronic medical records system in an integrated, public clinic in Malawi that serves HIV-infected and tuberculosis (TB) patients. METHODS Baobab Health Trust, the system developers, conducted a series of technical and clinical meetings with Lighthouse and Ministry of Health to determine specifications. Multiple pre-testing sessions assessed patient flow, question clarity, information sequencing, and verified compliance to national guidelines. Final components of the TB/HIV electronic medical records system include: patient demographics; anthropometric measurements; laboratory samples and results; HIV testing; WHO clinical staging; TB diagnosis; family planning; clinical review; and drug dispensing. RESULTS Our experience suggests that an electronic medical records system can improve patient management, enhance integration of TB/HIV services, and improve provider decision-making. However, despite sufficient funding and motivation, several challenges delayed system launch including: expansion of system components to include of HIV testing and counseling services; changes in the national antiretroviral treatment guidelines that required system revision; and low confidence to use the system among new healthcare workers. To ensure a more robust and agile system that met all stakeholder and user needs, our electronic medical records launch was delayed more than a year. Open communication with stakeholders, careful consideration of ongoing provider input, and a well-functioning, backup, paper-based TB registry helped ensure successful implementation and sustainability of the system. Additional, on-site, technical support provided reassurance and swift problem-solving during the extended launch period. CONCLUSION Even when system users are closely involved in the design and development of an electronic medical record system, it is critical to allow sufficient time for software development, solicitation of detailed feedback from both users and stakeholders, and iterative system revisions to successfully transition from paper to point-of-care electronic medical records. For those in low-resource settings, electronic medical records for integrated care is a possible and positive innovation.

Social involvement for community development in rural areas of Cuenca, Spain

Community development must be accompanied by a social involvement process which creates functional groups of citizens capable of taking responsibility for their own development. It is important that this process promotes the structuring of all population groups and provides the appropriate institutional and technical support. The present paper addresses these issues based on over 25 years of experience by the Association Instituto de Desarrollo Comunitario de Cuenca in revitalizing rural areas of the Spanish province of Cuenca. This paper analyses the social involvement process encouraged by this association, the relationships between public institutions and local associations, the role of these associations and the difficulties encountered in the rural areas. The long-term perspective of this experience provides some keys which can be used to successfully support the process of social involvement ―such as information on its characteristics and methodological tools―, establish local associations and create sustainable partnerships that foster the growth of leadership within the community development process.

Integración en la plataforma 4mobile de mecanismos de atención en redes sociales

El presente texto se ha desarrollado como Proyecto Fin de Grado en la Escuela Técnica Superior de Ingeniería y Sistemas de Telecomunicación de la Universidad Politécnica de Madrid en colaboración con la Consultora Tecnológica everis. El mismo tiene como objetivo realizar un estudio de los requisitos necesarios para poder desplegar un servicio que permita ofrecer a las Operadoras Móviles Virtuales (OMV) soporte técnico a sus clientes a través de las redes sociales. Este módulo establecerá una nueva vía de comunicación entre el consumidor y el cliente de la OMV con la propia OMV, el cual se caracterizará por una alta accesibilidad y una gran rapidez en el servicio permitiendo de este modo, una mayor satisfacción del cliente con su operador móvil y por tanto de una nueva vía para conseguir la fidelización del mismo y la captación de nuevos clientes. Para ello, este proyecto se lleva a cabo sobre el sistema de información 4mobile el cual es comercializado por la mencionada Consultora Tecnológica. Este sistema consiste en una plataforma web la cual permite cubrir todos los procesos de negocio comunes que un OMV necesita gestionar. Es por ello, que el mencionado estudio se centra en la evaluación de los aspectos necesarios para la integración de un módulo de estas características dentro de la plataforma de 4mobile. Este módulo, estará basado en una herramienta software que permitirá gestionar el ciclo de vida completo del comentario realizado por el cliente a través de una red social, desde que es publicado por el cliente, hasta que se haya respondido al mismo y su solución sea considerada como satisfactoria por el cliente. Por ello, y de cara a definir correctamente esta herramienta, será necesario un detallado análisis el cual recoja diversos aspectos y que a lo largo del texto, será denominado como Plan de Marketing de Medios Sociales (PMMS). Estos aspectos versarán tanto de las necesidades tecnológicas para su mencionada integración, como de la serie de características funcionales que una solución basada en servicio técnico a través de las redes sociales deberá poseer con el objetivo de ofrecer un servicio técnico de calidad. Finalmente, estas funcionalidades y necesidades tecnológicas se expondrán en forma de propuesta a everis para su integración en la plataforma 4mobile junto con un análisis de diseño a alto nivel software de la solución a desarrollar. ABSTRACT. This text has been developed as Final Degree Project in the Escuela Técnica Superior de Ingeniería y Sistemas de Telecomunicación de la Universidad Politécnica de Madrid in collaboration with the Technology Consultant everis, aims to conduct a study of how to provide technical support through social networks and the evaluation of the integration of a social support module within the system platform 4mobile, which cover all business processes that need to manage a Mobile Virtual Network Operator (MVNO), which is marketed by above-mentioned consultant . This module will establish a new communication channel between the consumer and the client with the OMV and itself, which is characterized by high accessibility and great fast service. Thus will allow a higher customer satisfaction with him service and thus a new way to get the same loyalty and attract new customers To this end, this project is performed on the information system 4mobile which is marketed by the consulting part thereof everis. This system is a platform to cover all business processes that need to manage an MVNO. Therefore, the mentioned study focuses on the evaluation of the elements necessary for integrating module these features within the platform 4mobile. This module will be based on a software tool for managing the entire lifecycle of the comment made by the customer via social networking, from the moment it is published, until it has been respond and their solution is considered satisfactory for the customer. So, in order to properly define this tool, a detailed analysis which will be necessary to collect various aspects and throughout the text, it will be referred to as Plan of Social Media Marketing (PMMS). These aspects will be address both: the technological needs for the mentioned integration, and the number of functional characteristics-based service through social networking solution, as this must in order to provide a quality service Finally, these goals and requirements will be discussed as everis offer for integration into the platform 4mobile analysis along with a high level of software design to develop the solution.

Co-creación de semiconductores

El mercado de los semiconductores está saturado de productos similares y de distribuidores con una propuesta de servicios similar. Los procesos de Co-Creación en los que el cliente colabora en la definición y desarrollo del producto y proporciona información sobre su utilidad, prestaciones y valor percibido, con el resultado de un producto que soluciona sus necesidades reales, se están convirtiendo en un paso adelante en la diferenciación y expansión de la cadena de valor. El proceso de diseño y fabricación de semiconductores es bastante complejo, requiere inversiones cada vez mayores y demanda soluciones completas. Se requiere un ecosistema que soporte el desarrollo de los equipos electrónicos basados en dichos semiconductores. La facilidad para el diálogo y compartir información que proporciona internet, las herramientas basadas en web 2.0 y los servicios y aplicaciones en la nube; favorecen la generación de ideas, el desarrollo y evaluación de productos y posibilita la interacción entre diversos co-creadores. Para iniciar un proceso de co-creación se requiere métodos y herramientas adecuados para interactuar con los participantes e intercambiar experiencias, procesos para integrar la co-creación dentro de la operativa de la empresa, y desarrollar una organización y cultura que soporten y fomenten dicho proceso. Entre los métodos más efectivos están la Netnografía que estudia las conversaciones de las comunidades en internet; colaboración con usuarios pioneros que van por delante del Mercado y esperan un gran beneficio de la satisfacción de sus necesidades o deseos; los estudios de innovación que permiten al usuario definir y a menudo crear su propia solución y la externalización a la multitud, que mediante una convocatoria abierta plantea a la comunidad retos a resolver a cambio de algún tipo de recompensa. La especialización de empresas subcontratistas en el desarrollo y fabricación de semiconductores; facilita la innovación abierta colaborando con diversas entidades en las diversas fases del desarrollo del semiconductor y su ecosistema. La co-creación se emplea actualmente en el sector de los semiconductores para detectar ideas de diseños y aplicaciones, a menudo mediante concursos de innovación. El servicio de soporte técnico y la evaluación de los semiconductores con frecuencia es fruto de la colaboración entre los miembros de la comunidad fomentada y soportada por los fabricantes del producto. Con el programa EBVchips se posibilita el acceso a empresas pequeñas y medianas a la co-creación de semiconductores con los fabricantes en un proceso coordinado y patrocinado por el distribuidor EBV. Los semiconductores configurables como las FPGAs constituyen otro ejemplo de co-creación mediante el cual el fabricante proporciona el circuito integrado y el entorno de desarrollo y los clientes crean el producto final definiendo sus características y funcionalidades. Este proceso se enriquece con bloques funcionales de diseño, IP-cores, que a menudo son creados por la comunidad de usuarios. ABSTRACT. The semiconductor market is saturated of similar products and distributors with a similar proposal for services. The processes of co-creation in which the customer collaborates in the definition and development of the product and provides information about its utility, performance and perceived value, resulting in a product that solves their real needs, are becoming a step forward in the differentiation and expansion of the value chain. The design and semiconductor manufacturing process is quite complex, requires increasingly higher investments and demands complete solutions. It requires an ecosystem that supports the development of electronic equipments based on such semiconductors. The ease of dialogue and sharing information that provides internet, web 2.0-based tools and services and applications in the cloud; favor the generation of ideas, the development and evaluation of products and allows the interaction between various co-creators. To start a process of co-creation adequate methods and tools are required to interact with the participants and exchange experiences, processes to integrate the co-creation within the operations of the company, and developing an organization and culture that support and promote such process. Among the most effective methods are the Netnography that studies the conversations of the communities on the internet; collaboration with Lead Users who are ahead of the market and expect a great benefit from the satisfaction of their needs or desires; Innovation studies that allow the user to define and often create their own solution and Crowdsourcing, an open call to the community to solve challenges in exchange for some kind of reward. The specialization of subcontractors in the development and manufacture of semiconductors; facilitates open innovation in the context of collaboration with different entities working in the different phases of the development of the semiconductor and its ecosystem. Co-creation is used currently in the semiconductor sector to detect ideas of designs and applications, often through innovation’s contests. Technical support and evaluation of semiconductors frequently is the result of collaboration between members of the community fostered and supported by the manufacturers of the product. The EBVchips program provides access to small and medium-sized companies to the co-creation of semiconductors with manufacturers in a process coordinated and sponsored by the Distributor EBV. Configurable semiconductors like FPGAs are another example of co-creation whereby the manufacturer provides the integrated circuit and the development environment and customers create the final product by defining their features and functionality. This process is enriched with IP-cores, designs blocks that are often created by the user community.

Metodologías de gestión de proyectos y su implementación en la empresa

Este proyecto ha sido estructurado en tres bloques diferenciados que tiene como objetivo analizar el presente, pasado y futuro de la gestión de proyectos con una orientación clara a ofrecer apoyo a aquellas empresas que planeen realizar un giro en sus estructura de organización de trabajo hacia filosofías ágiles. La gestión de proyectos a acompañado al hombre desde el inicio de los tiempos, pero sin embargo no fue hasta nuestra historia más cercana cuando se comienza a tener conciencia de la necesidad de establecer aplicar métodos generales a la hora de afrontar proyectos de ingeniería. Pioneros fueron en este sentido personajes como Taylor, Fayol o Gantt, cuyas aportaciones iniciales posibilitaron el nacimiento de la gestión de proyectos a mediados del siglo XX. En las década sucesivas hasta nuestros días han aparecido un número considerable de metodologías, perfeccionando elementos anteriormente asimilados y adaptándose a la realidad tecnológica y social del momento. Este recorrido histórico se aborda en el primer bloque de este proyecto. Los puntos revisados en la introducción histórica proporcionan las bases de conocimiento para entender las principales características entre las grandes familias de metodologías que actualmente son implantadas en el mundo empresarial. Es precisamente este punto, el de la exposición y análisis de las metodologías más extendidas y contemporáneas a la elaboración de este proyecto, lo que se aborda en el segundo bloque. En él se desarrolla con intenso detalle dos metodologías de la familia de filosofías ágiles, elegidas entre las más extendidas en la industria: Scrum, eXtreme Programming (XP) y un híbrido de ambas. Para entender la dimensión del cambio filosófico en cuanto a la gestión de proyectos que emprenden estas metodologías, se hace necesario repasar cuales son las metodologías no ágiles más extendidas actualmente. Para ello se introducen metodologías como la llamada tradicional o PRINCE2, principalmente, ya que también se realiza un repaso más superficial por otras aproximaciones notables. El último bloque que construye el desenlace del proyecto, intenta responder a las cuestiones futuras relacionadas con la adopción de metodologías ágiles. Para ello se revisa los puntos más conflictivos a señalar en este proceso y se ofrecerán soluciones teóricas y prácticas para ayudar a las empresas en su fase de migración hacia filosofías de organización ágiles. Ya que toda empresa hoy en día debería tener un soporte tecnológico que ofrezca apoyo a su desarrollo empresarial, gran parte de la elaboración de este proyecto se ha dedicado a hacer un estudio comparativo de las actuales herramientas Open Source. Se han instalado y probado 25 herramientas para posteriormente seleccionar 3 que han sido analizadas en profundidad. Así mismo, se enumeran pros y contras de estas herramientas, aportando ideas de mejoras y trazando cuál debería ser su evolución para ofrecer una alternativa real a las herramientas comerciales orientadas a esta labor. Las empresas pueden utilizar este índice de herramientas de software para decidir si pueden sustentar su proceso de migración en una herramienta Open Source o si deben orientarse a herramientas comerciales o de creación propias. ABSTRACT. This project has been divided into three different blocks that aims to analyze the past, present and future of project management with a clear focus on providing support to those companies that are planning to make a shift in its organizational structure working towards agile philosophies . The project management has walked together with the humanity since the beginning of time , but it was on our recent history when it begins to become aware of the need to establish general methods to apply to engineering projects. There was pioneers like Taylor , Fayol or Gantt, whose contributions made possible the birth of project management in the mid- twentieth century. In the following decades, there was a considerable number of new methodologies, improving concepts and adapting then to the technological and social reality of the moment . This historical journey is addressed in the first block of this project. The different facts reviewed at the first block provide the knowledge to understand the key features among the most important families of methodologies that nowadays are implemented in the business world. It is precisely this point, the presentation and analysis of the most widespread methodologies what is addressed in the second block. Two of the most widespread agile methodologies are detailed: Scrum , eXtreme Programming ( XP ) and a hybrid of both . In order to understand the philosophical shift in terms of project management performed by these methodologies , it is necessary to review what are the most widespread no agile methodologies currently. For this purpose, methodologies like Waterfall or PRINCE2 are explained. Other no agile methodologies are explained as well, but not so deeply in comparison with them. The last section of this project is the conclusion, it tries to answer future questions related to the adoption of agile methodologies. For that reason, the most important milestones are reviewed to provide theoretical and practical solutions and answers to help companies in this migration process toward agile methodologies. Since every company should has a solid technical support for its business development, a considerably part of the time has been applied to make a comparative study of the existing Open Source tools. 25 tools have been installed and tested. Then, 3 tools has been selected to be analyzed deeply. Also, pros and cons of these tools have been exposed in order to suggest a roadmap to offer a real alternative to the existing commercial tools in this business area. The companies that are involved in a migration progress toward a agile methodology can used this study about the available Open Source tools to decide if they can afford the migration process based on one of them or if they should use a commercial tool or a tailor-made software.

Atención al cliente y medios sociales en la empresa

online donde el contenido es creado por los propios usuarios mediante el uso de las tecnologías de la web 2.0, que facilitan la edición, la publicación y el intercambio de información, de tal manera que los social media están democratizando las comunicaciones. Según datos publicados por eMarketer, casi el 25% del total de la inversión publicitaria mundial para el 2014 estará dirigida a medios digitales. Los medios de comunicación tradicionales están sumidos desde algún tiempo en una profunda crisis. En los comienzos de Internet, los protagonistas de este sector han creído en la red como un medio de publicación de contenidos en una única dirección, esto es la web 1.0, personas conectándose a páginas web. El típico lector de revista y seminario se ha convertido en un nuevo consumidor con necesidades muy distintas. El lector de un medio tradicional se encuentra con contenido cerrado, sin posibilidad de ser filtrado, que busca dirigir su opinión. Con el método tradicional no es posible ni personalizar el contenido ni la experiencia de uso. De ahí el nacimiento de la web 2.0, personas conectándose a personas (redes sociales). En un futuro cercano, van a triunfar las empresas, sectores y marcas que sepan adaptarse a la llegada de los social media, y que además de desarrollar su línea de negocio habitual, se conviertan en plataformas para la conversación y la construcción de contenidos en colaboración. En este proyecto voy a desarrollar el caso particular de una empresa de telecomunicaciones con una estrategia que use los social media como plataforma de atención al cliente, y para interaccionar también con su almacén en DHL. Los servicios añadidos que dicha empresa de telecomunicaciones ofrece a sus seguidores, clientes externos e internos se pueden agrupar en las siguientes funcionalidades:  Hacer un volcado del sistema de gestión de incidencias de una empresa de telecomunicaciones en las redes sociales, a través de mensajes privados. Dichos mensajes privados se enviarán a las páginas de Facebook y Twitter de los clientes.  Seguimiento por parte del cliente de puestas en marcha de los nuevos servicios a través de mensajes privados en Facebook y Twitter. Mediante este servicio el cliente podrá comprobar a través de las redes sociales el estado de su pedido e intercambiar información de utilidad con la empresa.  Desarrollar a través de las redes sociales una herramienta de marketing para interaccionar con los clientes y posibles seguidores. A través de los canales de los social media se proporciona a los seguidores información de valor sobre novedades del mercado de las telecomunicaciones, soporte técnico, dudas, consejos sobre implementaciones técnicas, equipos de telecomunicaciones,.etc.Es decir, crear una plataforma de conversación entre usuarios, que aporte a los seguidores conocimientos y soluciones útiles para la problemática de sus negocios.  Usar Facebook como base de datos y medio de comunicación entre nuestra empresa de telecomunicaciones y el almacén externalizado en DHL. Supongo que la primera pregunta que debo responder sería, ¿por qué un cliente de una empresa de telecomunicaciones estaría interesado en seguir a su proveedor a través de redes sociales? Facebook tiene en 2014 1,28 billones de usuarios activos. Twitter, la cuarta plataforma social por número de usuarios tras Facebook, alcanzó los 255 millones de usuarios en los primeros meses de 2014. La segunda red social en número de seguidores es Youtube, con un billón de usuarios. El 61,5% de los usuarios de Facebook visita la red todos los días. Los twitteros envían 110 millones tweets por día, tienen fama de muy activos, especialmente por la mañana. En 60 días, se sube más contenido de vídeo a YouTube que el producido por las tres principales cadenas de televisión estadounidense durante 60 años. Como conclusión, las redes sociales están ganando cada día más terreno, es un entorno de comunicación bidireccional en auge cada vez más extendido, por lo cual los usuarios no tienen que dedicar tiempo extra a conocer la herramienta de atención al cliente de su empresa, al usar ésta un canal fácil, conocido, rápido, versátil y gratuito como son las redes sociales. ABSTRACT. Social media are platforms of online communication where content is created by users themselves using technologies of web 2.0, which facilitate the editing, publication and the exchange of information, so that the social media are democratizing communications. According to data published by eMarketer, nearly 25% of the total global ad spend for 2014 will target digital media. The traditional media are trapped for some time in deep crisis. In the early days of the internet, the players of the sector have believed in the network as a means of publishing content in a single direction, this is the web 1.0, connecting people to websites. The typical magazine reader has become a new consumer with very different needs. Traditional medium readers encounter a closed content, unable to be filtered, which seeks handle their opinion. The traditional method doesn’t allow to customize the content and user experience. Hence the birth of Web 2.0, connecting people to people. In the near future, will succeed companies, sectors and brands who can adapt to the advent of social media, and further to develop their line of business as usual, become platforms for conversation and building collaborative content. In this project I will develop the particular case of a telecommunications company with a strategy to use social media as a platform for Customer Service, and also to interact with DHL warehouse. The additional services that the company offers telecommunications followers, external and internal customers can be grouped into the following functionality:  Make a dump of the incident management system of a telecommunications company in social networks through private messages. These private messages are sent Facebook and Twitter clients.  Monitoring by the client launched new services through private messages on Facebook and Twitter. Through this service, customers can check through the social networks of your order status and share useful information with the company.  Develop through social media as a marketing tool to interact with customers and potential followers.Our telco will provide to followers through social media channels valuable information on market developments in telecommunications, technical support, questions, advice on technical implementations, telecommunications equipment,etc. Then we create a platform for discussion between users, to provide followers useful knowledge and solutions to their business problems.  Use Facebook as a database and means of communication between our telco and outsourced telecommunications in DHL warehouse. I guess the first question that must be answered is why a customer of a telecommunications company would be interested in following your provider via social networks. Facebook has 1.28 billion active users in 2014. Twitter, the fourth social platform for many users after Facebook reached 255 million users in the first months of 2014. The second social network on number of followers is YouTube, with a billion users. 61.5% of Facebook users visit the network every day. The twitter users send 110 million tweets per day, have a reputation for very active, especially in the morning. In 60 days, it is produced more video content to YouTube by the three major US television for 60 years. In conclusion, social networks are gaining more ground every day. It is an environment of two-way communication on the rise, so users do not have to spend extra time to learn the tool of Customer Care telco, by using this easy, known, fast, versatile and free channels as are social networks.

Determinación de los parámetros de diseño a aplicar al proyecto de grandes yates a motor, en base a nuevos requerimientos de eficiencia energética y protección del medioambiente marino

Durante los últimos años, la construcción de grandes yates ha evolucionado hacia conceptos y diseños más complejos dónde se ha priorizado en muchas ocasiones la estética arquitectónica y exigencias de confort de los armadores y operadores dejando en segundo plano aspectos clave de seguridad. Diferentes Organismos Internacionales y las Sociedades de Clasificación han venido adaptando sus requisitos a la problemática específica de este tipo de buques, tratando de compatibilizar tendencias de diseño con exigencias de resistencia, integridad estructural, estanqueidad y seguridad entre otras. En la actualidad, la construcción de grandes yates con esloras incluso por encima de los 100 metros, el aumento del número de pasajeros por encima del límite tradicional de 12, las nuevas tendencias de ahorro energético y protección medioambiental que se están implantando en la industria en general y marítima en particular, plantean una serie de desafíos tanto a los diseñadores como a las Sociedades de Clasificación que deben avanzar en sus reglamentaciones para cubrir estos y otros aspectos. Son precisamente estos aspectos medioambientales, tradicionalmente relegados en la industria de grandes yates los que están ocupando en la actualidad un primer plano en los desarrollos de normativa de diferentes Organismos Internacionales y Nacionales. El impacto que estas nuevas normativas van a tener sobre el diseño de grandes yates a motor centra el desarrollo de esta Tesis. Hasta donde ha podido conocer el doctorando, esta es la primera vez que en una Tesis Doctoral se abordan los principales mecanismos que regulan el diseño y la construcción de grandes yates a motor, se estudian y analizan las regulaciones internacionales en materia de protección medioambiental y de eficiencia energética aplicables a los yates, se seleccionan y describen un conjunto de tecnologías maduras de carácter medioambiental, susceptibles de ser empleadas en yates y se determina los parámetros y aspectos del diseño a aplicar al proyecto de grandes yates a motor como resultado de la aplicación de estas tecnologías, analizados bajo la perspectiva de la Sociedad de Clasificación y de los Organismos Internacionales. La Tesis comienza con un análisis de la industria de construcción de grandes yates, la flota existente de grandes yates, la cartera actual de pedidos y la evolución esperada del mercado. Aquí se pone de manifiesto que a pesar de la crisis económica global de los últimos años, este mercado goza relativamente de buena salud y las previsiones son favorables, particularmente para el sector en Europa. A continuación se aborda el estado del arte del diseño de yate grande, sus peculiaridades, particularmente estructurales y de armamento, que le diferencian de otros tipos de buques y las tendencias en su diseño. Se pone de manifiesto cómo el proyecto de estos yates ha evolucionado hacia yates de gran tamaño y complejidad técnica, debido a la demanda y necesidades actuales y cómo ha influido en aspectos como la disposición estructural. Seguidamente se describen los principales mecanismos que regulan el diseño y construcción de grandes yates, particularmente el Código de Grandes Yates Comerciales de la Maritime & Coastguard Agency del Reino Unido, y las Reglas y Reglamentos de la Sociedad de Clasificación Lloyd’s Register para la Clasificación de yates; por ser ambas organizaciones las que lideran el Registro y la Clasificación respectivamente de este tipo de buques, objeto del estudio. El doctorando ejerce su actividad profesional como inspector de Lloyd’s Register en una oficina técnica de apoyo y evaluación de diseño, siendo especialista en grandes yates, lo que ha permitido exponer de primera mano el punto de vista de la Sociedad de Clasificación. En el siguiente Capítulo se describen las principales reglamentaciones internacionales de carácter medioambiental que afectan al diseño, construcción y operación de los yates, algunas de las cuales, como es el caso del Convenio Internacional para el Control y la Gestión del Agua de Lastre y Sedimentos de los buques (BWM 2004) aún no ha entrado en vigor a la fecha de terminación de esta Tesis. Seguidamente se realiza una selección de tecnologías desde el punto de vista de protección medioambiental y ahorro energético y su aplicación al diseño y construcción de grandes yates. Algunas de estas tecnologías son maduras y ya habían sido utilizadas con éxito en otros tipos de buques, pero su aplicación a los yates entraña ciertos desafíos que se describen en este Capítulo. A continuación se determinan y analizan los principales parámetros de diseño de los yates grandes a motor como consecuencia de las tecnologías estudiadas y se indican una serie de aspectos de diseño bajo la perspectiva de la Sociedad de Clasificación y de los Organismos Marítimos Internacionales. Finalmente se llega a una serie de conclusiones y se identifican futuras líneas de investigación en relación a las tecnologías descritas en este trabajo. ABSTRACT In recent years, the building of large yachts has evolved into more complex concepts and designs where often prioritized architectural aesthetics and comfort requirements of owners and operators leaving in the background key security aspects. Several international organizations and classification societies have been adapting their requirements to the specific problems of this type of vessel, trying to reconcile demands design trends with resistance, structural integrity, watertightness and safety among others. At present, the building of large yachts with lengths even above 100 meters, the increase in passenger numbers over the traditional limit of 12, new trends of energy saving and environmental protection are being implemented in the marine industry in particular, they pose a number of challenges to both designers and classification societies that should update and improve their regulations to cover these and other aspects. It is precisely these environmental issues, traditionally relegated to the large yacht industry, which are currently occupying center stage in the development of rules of different international and national bodies. The impact that these new standards will have on the design of large motor yachts focuses the development of this thesis. As far as it is known, this is the first time in a doctoral thesis the main mechanisms regulating the design and construction of large motor yachts are addressed, the international regulations on environmental protection and energy efficiency requirements for yachts are studied and analyzed, a set of mature environmental technologies, capable of being applied to yachts are selected and described, the parameters and design aspects to be applied to large yacht projects as a result of the application of these technologies are determined and analyzed from the perspective of the Classification Society and international organizations. The thesis begins with an analysis of the shipbuilding industry of large yachts, the existing fleet of large yachts, the current backlog and the expected market developments. Here it becomes clear that despite the global economic crisis of recent years, this market enjoys relatively good health and prospects are favorable, particularly for the sector in Europe. Then the state of the art of large yacht design, its peculiarities, particularly structural and outfitting, that differentiate it from other types of ships and trends in design is discussed. It shows how the project of these yachts has evolved to large yachts and technical complexity, due to the demand and needs and how it has influenced the structural arrangement aspects. Then the main mechanisms regulating the design and construction of large yachts, particularly the Large Commercial Yacht Code developed by the Maritime & Coastguard Agency (UK) and the Lloyd’s Register Rules & Regulations for the Classification of Special Service Craft including yachts are described; the two organizations to be leading the registration and classification respectively of such vessels under study. The doctoral student practices his profession as a senior specialist to Lloyd’s Register in a technical support office, dealing with the design assessment of large yachts, which allowed exposing firsthand view of the Classification Society. In the next chapter describes the main international environmental regulations, affecting the design, construction and operation of yachts, some of which, such as the International Convention for the Control and Management of Ships' Ballast Water and Sediments (BWM 2004) has not yet entered into force at the date of completion of this thesis. Following is a selection of technologies from the point of view of environmental protection and energy saving and its application to design and construction of large yachts. Some of these technologies are mature and have already been used successfully in other ship types, but their application to yachts entails certain challenges that are described in this chapter. Then identifies and analyzes the main design parameters of large motor yachts as a result of the technologies studied and a number of design aspects are given from the perspective of Classification Society and international maritime organizations. Finally, a number of conclusions are exposed, and future research is identified in relation to the technologies described in this Thesis.

Low-temperature concentration of tellurium and gold in continental red bed successions

Acknowledgements This research was supported by NERC grants (NE/L001764/1, NE/M010953/1). We are grateful to J. Still and A. Sandison for technical support and to the gypsum mines and C. Brolley for access and sampling. Critical comments from Cristiana Ciobanu, Eric Gloaguen and Georges Calas are gratefully acknowledged. The authors have no conflicts of interest to declare

Anisakis infection in allis shad, Alosa alosa (Linnaeus, 1758), and twaite shad, Alosa fallax (Lacépède, 1803), from Western Iberian Peninsula Rivers : zoonotic and ecological implications

Acknowledgments The authors would like to thank M. N. Cueto and J.M. Antonio (ECOBIOMAR) for their excellent technical support and also Rodrigo López for making the map of the study area. We also thank the personal of the Vigo IEO, for providing information about shad captures at sea collected on the basis of national program (AMDES) included in the European Data Collection Framework (DCF) project. We are also grateful to Comandancia Naval de Tui for providing fishing data. M. Bao is supported by a PhD grant from the University of Aberdeen and also by financial support of the contract from the EU Project PARASITE (grant number 312068). This study was partially supported by a PhD grant from the Portuguese Foundation for Science and Technology (FCT) SFRH/BD/44892/2008) and partially supported by the European Regional Development Fund (ERDF) through the COMPETE—Operational Competitiveness Programme and national funds through Foundation for Science and Technology (FCT), under the project BPEst-C/MAR/ LA0015/2013. The authors thank the staff of the Station of Hydrobiology of the USC BEncoro do Con^ due their participation in the surveys. This work has been partially supported by the project 10PXIB2111059PR of the Xunta de Galicia and the project MIGRANET of the Interreg IV BSUDOE (South-West Europe) Territorial Cooperation Programme (SOE2/P2/E288). D.J. Nachón is supported by a PhD grant from the Xunta de Galicia (PRE/2011/198)

Isolation of 'Candidatus Nitrosocosmicus franklandus', a novel ureolytic soil archaeal ammonia oxidiser with tolerance to high ammonia concentration

Acknowledgements. The authors would like to thank Mr Kevin Mackenzie and Mrs Gillian Milne (University of Aberdeen) for technical support with scanning electron microscopy, and Dr Robin Walker for access to the Woodlands Field experimental plots at the SRUC,Craibstone Estate, Aberdeen. This work was financially supported by Natural Environmental Research Council (standard grants NE/I027835/1 and NE/L006286/1 and fellowship NE/J019151/1), EC Marie Curie ITN NORA, Grant Agreement No. 316472, the AXA Research Fund and the Centre for Genome Enabled Biology and Medicine, University of Aberdeen.

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes

We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez for technical support in high-performance computing. This work was funded by Conacyt Mexico (grants No. 179290 and 177568) and FINNOVA Mexico (grant No. 214716) to FBG. PCM was funded by Conacyt scholarship (No. 28830) and a Cinvestav posdoctoral fellowship. JF and JFK acknowledge funding from the College of Physical Sciences, University of Aberdeen, UK.