Informe del Undécimo Período de Sesiones del Comité de Expertos Gubernamentales de Alto Nivel (CEGAN), Bogotá, Colombia, 3-6 marzo 1986 = Report of the Eleventh Session of the Committee of High-Level Government Experts (CEGAN), Bogota, Colombia, 3-6 March 1986

Contiene la organizacion de los trabajos, resumen de los debates y conclusiones de la reunion que tuvo por objetivo analizar, por una parte, la instrumentacion de la Estrategia Internacional del Desarrollo (EID) y las perspectivas de America Latina y el Caribe para el fin del decenio de 1980, teniendo presente la evolucion de la crisis y, por la otra, la deuda externa de America Latina y el Caribe.

Inmigración y urbanización en Bogotá, Colombia = Immigration and urbanization in Bogota, Colombia

Los documentos del Seminario fueron publicados por UNESCO en 1961 con el título: La urbanización en América Latina/Urbanization in Latin America

Buenos Aires, Bogota y San Jose: aplicacion del metodo de Brass para la medicion de la fecundidad y la mortalidad

Incluye Bibliografía

Efecto de la migracion en las estimaciones de fecundidad por el metodo de hijos propios. La Paz (Bolivia 1976) y Bogota D.E. (Colombia 1973); trabajo final de investigacion

Incluye Bibliografía

Colombia: migracion y fecundidad en Bogota, 1964; trabajo final de investigacion

Incluye Bibliografía

Informe del Taller de Trabajo La dimensión ambiental en la planificación del desarrollo de la sabana de Bogotá (Colombia)" = Report on the Workshop on the Environmental Dimension in Planning the Development of the Bogota Savanna (Colombia)"

Contiene las conclusiones y recomendaciones del Taller que tuvo por objetivo analizar las politicas de desarrollo y sus perspectivas en el area de influencia de la Corporacion Autonoma Regional de la sabana de Bogota y de las cuencas de los rios Bogota, Ubate y Suarez (CAR), con el proposito de recomendar las vias mas favorables para incorporar la dimension ambiental en la planificacion.

Estudio de caso: el sistema de la cuenca del río Bogotá: resumen = Case study: the Bogota river basin: summary

Incluye Bibliografía

The Digital Divide in the University: The Appropriation of ICT in Higher Education Students from Bogota, Colombia

The growth and integration of ICTs in the global economy have created conditions that profoundly affect our society, dividing communities between those who effectively appropriate these resources and those who do not, what is called the digital divide. This exploratory study seeks to propose and validate ways of assessing this phenomenon in higher education, from the construction of a model and a comprehensive methodology that value contextual conditions, in addition to measuring access factors and motivation for use, that have been employed in previous research. To obtain indications about the behavior of this phenomenon, we developed research with students from three universities in Bogota, administering 566 surveys in four phases that would test the variables proposed in the model. The results show that the variables of the model link causally, with the strongest relations between education, attitude towards ICTs and ICT application. Although students have good access to ICTs and high levels of education, no strong relationship was found in regards to perceived impact on production. This may be explained by a superficial appropriation of ICT, due to a context that is alien to its conditions of origin (industrialism, innovation), poor quality of education and economies not centered around R&D.

Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers

The DOK1 gene is a putative tumour suppressor gene located on the human chromosome 2p13 which is frequently rearranged in leukaemia and other human tumours. We previously reported that the DOK1 gene can be mutated and its expression down-regulated in human malignancies. However, the mechanism underlying DOK1 silencing remains largely unknown. We show here that unscheduled silencing of DOK1 expression through aberrant hypermethylation is a frequent event in a variety of human malignancies. DOK1 was found to be silenced in nine head and neck cancer (HNC) cell lines studied and DOK1 CpG hypermethylation correlated with loss of gene expression in these cells. DOK1 expression could be restored via demethylating treatment using 5-aza-2'deoxycytidine. In addition, transduction of cancer cell lines with DOK1 impaired their proliferation, consistent with the critical role of epigenetic silencing of DOK1 in the development and maintenance of malignant cells. We further observed that DOK1 hypermethylation occurs frequently in a variety of primary human neoplasm including solid tumours (93% in HNC, 81% in lung cancer) and haematopoietic malignancy (64% in Burkitt's lymphoma). Control blood samples and exfoliated mouth epithelial cells from healthy individuals showed a low level of DOK1 methylation, suggesting that DOK1 hypermethylation is a tumour specific event. Finally, an inverse correlation was observed between the level of DOK1 gene methylation and its expression in tumour and adjacent non tumour tissues. Thus, hypermethylation of DOK1 is a potentially critical event in human carcinogenesis, and may be a potential cancer biomarker and an attractive target for epigenetic-based therapy.