Gruss aus Bayreuth! : Triffst Du mich nicht zu Hause an, bin ich gewiss bei Angermann.

Signatur des Originals: S 36/F07101

Gerhart Hauptmann, Brustbild - Zitat: Gerhart Hauptmann: "Weiß nicht woher ich gekommen bin..."

Signatur des Originals: S 36/F12351

Die Zauberflöte : Königin d. Nacht: Ich bin zu Gram und Leid erkohren, Man raubte meine Tochter mir.

Signatur des Originals: S 36/G00157

Der Barbier von Sevilla : Figaro: Ich bin das Fac-totum Der schönen Welt,-

Signatur des Originals: S 36/G00170

Die Zauberflöte : Papageno: Der Vogelfänger bin ich ja, Stets lustig, hey͏̈sa hopsasa!

Signatur des Originals: S 36/G00172

Der Freischütz : Nach den Worten der Agathe: Schiess nicht! Ich bin die Taube!

Signatur des Originals: S 36/G00175

Oberon : Huon: Allmächtiger Himmel! Ich bin betrogen!

Signatur des Originals: S 36/G00176

Gustav Raeder als van Beth, Rollenbild, in: Albert Lortzing: Zaar und Zimmermann, 1. Akt, 6. Szene : O ich bin klug und weise, und mich betrügt man nicht etc.

Signatur des Originals: S 36/G03534

Gustav Raeder als van Beth, Rollenbild, in: Albert Lortzing: Zaar und Zimmermann, 1. Akt, 6. Szene : O ich bin klug und weise, und mich betrügt man nicht etc.

Signatur des Originals: S 36/G03535

"Fremd bin ich bei Euch und heimisch, gebt mir Besitz, meinen Todten zu begraben." : Predigt am Sabbath: חיי שרה [Ḥaye Śarah] im neuen Isr. Tempel in Hamburg

von Schwabacher

Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

Certain matrix metalloproteinases (MMP) are expressed within the fibrous areas surrounding acellular lipid cores of atherosclerotic plaques, suggesting that these proteinases degrade matrix proteins within these areas and weaken the structural integrity of the lesion. We report that matrilysin and macrophage metalloelastase, two broad-acting MMPs, were expressed in human atherosclerotic lesions in carotid endarterectomy samples (n = 18) but were not expressed in normal arteries (n = 7). In situ hybridization and immunohistochemistry revealed prominent expression of matrilysin in cells confined to the border between acellular lipid cores and overlying fibrous areas, a distribution distinct from other MMPs found in similar lesions. Metalloelastase was expressed in these same border areas. Matrilysin was present in lipid-laden macrophages, identified by staining with anti-CD-68 antibody. Furthermore, endarterectomy tissue in organ culture released matrilysin. Staining for versican demonstrated that this vascular proteoglycan was present at sites of matrilysin expression. Biochemical studies showed that matrilysin degraded versican much more efficiently than other MMPs present in atherosclerotic lesions. Our findings suggest that matrilysin, specifically expressed in atherosclerotic lesions, could cleave structural proteoglycans and other matrix components, potentially leading to separation of caps and shoulders from lipid cores.