Estratégias biotecnológicas para a liberação controlada de antígenos e adjuvantes em vacinas através de lipossomas

Liposomes (LP) are colloidal systems with ability to compartmentalize therapeutic molecules in order to improve biological activity, decreases the potential toxicity, and to obtain prolonged effect. In this work it was discussed the role of the various liposomes types to encapsulate drug molecules able to provoke some immunological response (drugs, antigens and DNA). The effect of the liposomes and the parameters about the formation of the structures are also analyzed. Detailed literature review shows that, depending on the molecules polarity and the superficial charge of the liposome structures, the system may be efficiently used to optimize the therapeutic effects by means of the release control or through a drug delivery mechanism.

Energía, desarrollo industrial, contaminación del aire y la atmósfera y cambio climático en América Latina y el Caribe: nuevas políticas, experiencias, mejores prácticas y oportunidades de cooperación horizontal

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Qualidade de mudas seminais de eucalipto em função dos substratos e fertilização de liberação controlada

For the production of quality seedlings, depending on the physical characteristics of each substrate, more rational nutritional managements, from the of economic-environmental point of view, should be sought. This study aimed to evaluate the development and quality of Eucalyptus grandis × E. urophylla seedlings in terms of substrates and doses of controlledrelease Osmocote® fertilizer. The experiment was conducted with a completely randomized, factorial design, using as substrates: vermiculite+carbonized rice chaff+coconut fiber (1:1:1); vermiculite+coconut fiber (1:1) and vermiculite+coconut fiber (2:1) and doses of 2, 4, 6 and 8kg·m -3 of substrate. The substrates with higher water holding capacity allow seedlings to reach their maximum development in most parameters using lower doses of controlled-release fertilizer. We recommend the application of the controlled-release fertilizer at a dose of 6.0kg·m-3 in vermiculite+carbonized rice chaff+coconut fiber (1:1:1) and vermiculite+coconut fiber (2:1) substrates, and in substrate vermiculite+coconut fiber (1:1) at a dose of 7.0kg·m-3. In each substrate there is a dose range that promotes a greater formation of suitable root systems for planting in the field, which consequently results in seedlings with greater morphological development at nursery.

Teste de deterioração controlada para avaliação do vigor de sementes de milho (Zea mays L.)

Pós-graduação em Agronomia (Agricultura) - FCA

Considerações sobre analgesia controlada pelo paciente (PCA) em hospital universitário

Pós-graduação em Anestesiologia - FMB

Almacenamiento y recuperacion de informacion estadistica

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Membrana transdérmica de liberação controlada utilizando quitosana, plasma e plaquetas para a regeneração de feridas

Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

Preservación, manejo y almacenamiento del bagazo

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Estructura y funcionamiento de las plantas de almacenamiento y conservación de granos en Centroamérica

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Avaliação de diferentes frações inspiradas de oxigênio em cães anestesiados com infusão contínua de propofol e rocurônio, mantidos em ventilação controlada a pressão

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Formadores de filmes híbridos orgânicos inorgânicos do tipo ureasil-poliéter para liberação controlada de fármacos

Pós-graduação em Ciências Farmacêuticas - FCFAR