Detection of codon 12 mutation in the k-ras oncogene in pancreatic tumors

Mutations at codons 12, 13, or 61 of the H-ras, K-ras, and N-ras have been detected in human neoplasias by a variety of techniques. Some of these techniques are very sensitive and can detect K-ras mutation in 90% of the cases of pancreatic adenocarcinomas. We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed paraffin embedded tissue sections. K-ras mutations at codon 12 were detected by a two-step PCR-enriched technique in all the samples of pancreatic adenocarcinoma, but not in cystadenoma or control samples. This technique may be useful for early detection of pancreatic cancer.

Fiscal Update, December 13, 1999

The Fiscal Division newsletter, published weekly during session and periodically during the interim.

Fiscal Update, December 13, 2002

The Fiscal Division newsletter, published weekly during session and periodically during the interim.

Fiscal Update, December 13, 2007

The Fiscal Division newsletter, published weekly during session and periodically during the interim.

The Update, December 13, 2010

The Update is a bi-weekly web newsletter published by the Iowa Department of Public Health's Bureau of Family Health. It is posted the second and fourth week of every month, and provides useful job resource information for departmental health care professionals, information on training opportunities, intradepartmental reports and meetings, and additional information pertinent to health care professionals.

Report and Recommendations of the Iowa Vertical Infrastructure Advisory Committee, December 13, 2011

This report summaries the work of the committee over the last year and its vision for the future. The committee is followed with interest the work of the Department of Corrections and the Department of Veterans Affairs in evaluating the needs of their facilities and recommends similar evaluations of facilities around the state by other agencies. The committee members are ready to offer advice on the needs of the state's again infrastructure and steps that could be taken to evaluate vacant and underutilized buildings and reduce operational and maintenance costs.

U.S. 61 dedication, December 13, 1984

Program from the dedication ceremony of the new U.S. 61 Muscatine Bypass.

EPI Update, April 12, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

EPI Update: Special Alert, July 12, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health. SPECIAL ALERT

Quick Reads, November 12, 2013

IDPH Quick Reads is an electronic newsletter produced by the Director’s Office at the Iowa Department of Public Health. IDPH Quick Reads are published every three to four weeks.

Friday Facts, December 13, 2013, Vol. 195

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Footnotes, December 2013, Vol. 38, no.10-12

Monthly newsletter of State Library

2013 Elder Abuse Task Force Final Report Pursuant to Senate File 446, Section 50, December 13, 2013

Per the guidance of the Legislative Elder Abuse Prevention and Intervention Interim Committee, a prioritization of the implementation recommendations and proposed legislation are below listed in the order determined in the 2012 Elder Abuse Task Force Report.

EPI Update, December 13, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.