[14 juillet 1919, Hôtel de ville et place de l'Hôtel de ville de Paris décorés et illuminés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54999

[14 juillet 1919, Hôtel de ville et place de l'Hôtel de ville de Paris décorés et illuminés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55000

[14 juillet 1919, un bal populaire dans Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55001

[14 juillet 1919, un bal populaire dans Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55002

[Segni. Porta Saracena]

Référence bibliographique : Weigert, 658

Molecular substitution rate increases in myrmecophilous lycaenid butterflies (Lepidoptera)

Is species diversification driven by neutral- or niche-based processes? Butterflies of the Lycaenidae family have developed mutualistic interactions with ants. This biotic requirement increased the spatial fragmentation of populations of lower effective population size (Ne) compared with autonomous species. The nearly neutral theory predicts that species with smaller Ne should fix more mutations because of the increased strength of drift. Taking into account the phylogenetic relatedness among species, this study shows that species with a stronger dependence on ants displayed more intra-specific Single Nucleotide Polymorphisms compared with species with low or no myrmecophily. This phenomenon can cause more pronounced genetic differentiation between populations and could ultimately promote speciation in a similar manner as on physical islands. The large species diversity observed in this family could be the consequence of this neutral process enhancing the diversification of lineages.

The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.

Cilengitide is a high-affinity cyclic pentapeptdic alphaV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through alphaVbeta3/alphaVbeta5 integrins. Angiogenic endothelial cells express multiple integrins, in particular those of the beta1 family, and little is known on the effect of cilengitide on endothelial cells expressing alphaVbeta3 but adhering through beta1 integrins. Through morphological, biochemical, pharmacological and functional approaches we investigated the effect of cilengitide on alphaVbeta3-expressing human umbilical vein endothelial cells (HUVEC) cultured on the beta1 ligands fibronectin and collagen I. We show that cilengitide activated cell surface alphaVbeta3, stimulated phosphorylation of FAK (Y(397) and Y(576/577)), Src (S(418)) and VE-cadherin (Y(658) and Y(731)), redistributed alphaVbeta3 at the cell periphery, caused disappearance of VE-cadherin from cellular junctions, increased the permeability of HUVEC monolayers and detached HUVEC adhering on low-density beta1 integrin ligands. Pharmacological inhibition of Src kinase activity fully prevented cilengitide-induced phosphorylation of Src, FAK and VE-cadherin, and redistribution of alphaVbeta3 and VE-cadherin and partially prevented increased permeability, but did not prevent HUVEC detachment from low-density matrices. Taken together, these observations reveal a previously unreported effect of cilengitide on endothelial cells namely its ability to elicit signaling events disrupting VE-cadherin localization at cellular contacts and to increase endothelial monolayer permeability. These effects are potentially relevant to the clinical use of cilengitide as anticancer agent.

Lettre de M. l'abbé de ***, à un curé de ses amis, à l'occasion du serment civique décrété le 16 novembre dernier ([Reprod.])

Collection : Les archives de la Révolution française ; 8.658

[Défilé du 14 juillet 1919 passant sous l'Arc de triomphe de l'Etoile, un maréchal à cheval et l'armée française] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54957

[Défilé du 14 juillet 1919, l'Arc de triomphe de l'Etoile et la foule] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54958

[Défilé du 14 juillet 1919, une délégation civile américaine] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54958 [bis]

[Défilé du 14 juillet 1919 passant sous l'Arc de triomphe de l'Etoile, l'armée française] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54959

[Défilé du 14 juillet 1919 passant sous l'Arc de triomphe de l'Etoile, Joffre et Foch précédant la cavalerie] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54960