MPK-09, a small molecule inspired from bioactive styryllactone restores the wild-type function of mutant p53

In the search for more efficacious and less toxic cancer drugs, the tumor suppressor p53 protein has long been a desirable therapeutic target. In the recent past, few independent studies have demonstrated that the antitumor activity of wild-type p53 can be restored in cancer cells harboring mutant form of p53 using small molecule activators. In this study, we describe a novel small molecule MPK-09, which is selective and highly potent against allele specific p53 mutations mainly, R175H, R249S, R273H, R273C, and E285K. Except E285K, all other mutations tested are among the six ``hot spot'' p53 mutations reported in majority of human cancer. Furthermore, our study conclusively demonstrates that the apoptotic activity of the small molecule MPK-09 against cancer cells harboring R273C and E285K mutations is due to restoration of the wild-type conformation to the corresponding mutant form of p53.

Primeira avaliação orçamentária de 2009 : contingenciamento de abril (Decreto 6.808/09)

Consultoria de Orçamento e Fiscalização Financeira - Núcleo de Assuntos Econômico-Fiscais.

[Discurso do Deputado Jofran Frejat : Sessão da Assembleia Nacional Constituinte de 09 de fevereiro de 1987]

Defende a necessidade de complementar a autonomia política do Distrito Federal, através da eleição direta para Governador, Vice-governador e Legislativo local.

[Discurso do Deputado Valério Magalhães : Sessão da Câmara dos Deputados de 09 de novembro de 1962]

Questiona as reclamações de deputados quanto às condições de trabalho e de habitabilidade de Brasília e alerta quanto às manifestações para o retorno da Capital para o Rio de Janeiro.

[Discurso do Deputado João Agripino : Sessão da Câmara dos Deputados de 09 de agosto de 1956]

Discussão do Projeto de Lei nº 1.234, de 1956, que dispõe sobre a mudança da Capital Federal e dá outras providências. Reparos à natureza jurídica e aos plenos poderes dados à Companhia Urbanizadora da Nova Capital. Apresentação de emendas ao PL 1.234/56. Apartes: Emival Caiado, Wagner Estelita, Fonseca e Silva e Corrêa e Costa.

[Discurso do Deputado Tenório Cavalcanti : Sessão da Câmara dos Deputados de 09 de agosto de 1956]

Discussão do Projeto de Lei nº 1.234, de 1956, que dispõe sobre a mudança da Capital Federal e dá outras providências. Classifica como demagógica a matéria em apreciação e apresenta aspectos que corroboram sua convicção da inexequibilidade da mudança da Capital Federal, entre eles as críticas do Engenheiro Prestes Maia. Defende a autonomia política do Distrito Federal e a aplicação de verbas no interior do país para cessar o fluxo migratório para o litoral e desenvolver o crescimento do interior do País.

[Discurso do Deputado Emival Caiado : Sessão da Câmara dos Deputados de 09 de agosto de 1956]

Discussão do Projeto de Lei nº 1.234, de 1956, que dispõe sobre a mudança da Capital Federal e dá outras providências. Anúncio de que falará sobre a matéria no horário do Grande Expediente da próxima sessão.

Cruise Report: Summer 2008 Ecological Assessment of Stellwagen Bank National Marine Sanctuary NOAA Ship NANCY FOSTER NF-08-09-CCEHBR (June 14-June 21, 2008)

Summary: This cruise report is a summary of a field survey conducted within the Stellwagen Bank National Marine Sanctuary (SBNMS), located between Cape Cod and Cape Ann at the mouth of Massachusetts Bay. The survey was conducted June 14 – June 21, 2008 on NOAA Ship NANCY FOSTER Cruise NF-08-09-CCEHBR. Multiple indicators of ecological condition and human dimensions were sampled synoptically at each of 30 stations throughout SBNMS using a random probabilistic sampling design. Samples were collected for the analysis of benthic community structure and composition; concentrations of chemical contaminants (metals, pesticides, PAHs, PCBs, PBDEs) in sediments and target demersal biota; nutrient and chlorophyll levels in the water column; and other basic habitat characteristics such as depth, salinity, temperature, dissolved oxygen, turbidity, pH, sediment grain size, and organic carbon content. In addition to the fish samples that were collected for analysis of chemical contaminants relative to human-health consumption limits, other human-dimension indicators were sampled as well including presence or absence of fishing gear, vessels, surface trash, marine mammals, and noxious sediment odors. The overall purpose of the survey was to collect data to assess the status of ecosystem condition and potential stressor impacts throughout SBNMS, based on these various indicators and corresponding management thresholds, and to provide this information as a baseline for determining how such conditions may be changing with time. While sample analysis is still ongoing a few preliminary results and observations are reported here. A final report will be completed once all data have been processed. The results are anticipated to be of value in supporting goals of the SBNMS and National Marine Sanctuary Program aimed at the characterization, protection, and management of sanctuary resources (pursuant to the National Marine Sanctuary Reauthorization Act) as well as a new priority of NCCOS and NOAA to apply Ecosystem Based approaches to the Management of coastal resources (EBM) through Integrated Ecosystem Assessments (IEAs) conducted in various coastal regions of the U.S. including the Northeast Atlantic continental shelf. This was a multi-disciplinary partnership effort made possible by scientists from the following organizations:  NOAA, National Ocean Service (NOS), National Centers for Coastal Ocean Science (NCCOS), Center for Coastal Environmental Health and Biomolecular Research (CCEHBR), Charleston, SC.  U.S. Environmental Protection Agency (EPA), National Health and Environmental Effects Research Laboratory (NHEERL), Atlantic Ecology Division (GED), Narragansett, RI.  U.S. Environmental Protection Agency (EPA), National Health and Environmental Effects Research Laboratory (NHEERL), Gulf Ecology Division (GED), Gulf Breeze, FL.  U.S. Geological Survey (USGS), National Wetlands Research Center, Gulf Breeze Project Office, Gulf Breeze, FL.  NOAA, Office of Marine and Aviation Operations (OMAO), NOAA ship Nancy Foster. (31pp) (PDF contains 58 pages)

Ergebnisse der 23. Jahrestagung der Internationalen Ostsee-Fischereikommission (IBSFC) vom 08.-12.09.1997 und Ausblick

Die Tagung fand in Warschau, dem Sitz des Sekretariats der IBSFC, statt. Arbeitsebenen der Tagung sind Plenarsitzungen und Sitzungen der beiden Ständigen Komitees „Regulierungsmaßnahmen“ und „Finanzen“. Die Plenarsitzungen und Sitzungen des Ständigen Komitees für Regulierungsmaßnahmen mit insgesamt 34 Tagungsordnungspunkten waren geprägt von der Analyse der nationalen Fischereien im Basiszeitraum, d.h. von der Ausnutzung der nationalen Quoten für 1996 und z.T. 1997, den Beratungen zum Fischereimanagement für 1998, aber auch vom Vorsorgeansatz im Fischereimanagement und den Auswirkungen der sogenannten Rio-Konferenz (UN-Konferenz über Umwelt und Entwicklung, Rio de Janeiro 1992) für den Ostseeraum.