Lottery Action, November 17-30, 2003, Vol. 10, no. 23

Newsletter for Iowa Lottery

Fourteen new cases contribute to the characterization of the 7q11.23 microduplication syndrome.

Interstitial deletions of 7q11.23 cause Williams-Beuren syndrome, one of the best characterized microdeletion syndromes. The clinical phenotype associated with the reciprocal duplication however is not well defined, though speech delay is often mentioned. We present 14 new 7q11.23 patients with the reciprocal duplication of the Williams-Beuren syndrome critical region, nine familial and five de novo. These were identified by either array-based MLPA or by array-CGH/oligonucleotide analysis in a series of patients with idiopathic mental retardation with an estimated population frequency of 1:13,000-1:20,000. Variable speech delay is a constant finding in our patient group, confirming previous reports. Cognitive abilities range from normal to moderate mental retardation. The association with autism is present in five patients and in one father who also carries the duplication. There is an increased incidence of hypotonia and congenital anomalies: heart defects (PDA), diaphragmatic hernia, cryptorchidism and non-specific brain abnormalities on MRI. Specific dysmorphic features were noted in our patients, including a short philtrum, thin lips and straight eyebrows. Our patient collection demonstrates that the 7q11.23 microduplication not only causes language delay, but is also associated with congenital anomalies and a recognizable face.

Traitement chirurgical de la diplopie secondaire à l'orbitopathie dysthyroïdienne [Surgical treatment of diplopia in Graves' orbitopathy]

BACKGROUND: The correction of oculomotor disorder in Grave's disease is applied on pathological extraocular muscles. Based on the global muscular restriction (bilateral forced duction test) and angular measurements, we have used a non-adjustable technique. PATIENTS AND METHODS: We performed a retrospective analysis of 21 patients (23 operations) with thyroid-associated orbitopathy operated for persisting diplopia. The angles of deviation in the 9 diagnostic directions of gaze and the field of binocular vision were measured with the Harm's tangent scale before and after surgery. Sixteen patients were operated only on vertical muscles. The mean follow-up was 45 months. RESULTS: 76 % of the patients (95 % confidence interval [CI], 58-94 %) obtained a large and centred field of binocular vision without prisms. 14 % (95 % CI, 0-29 %) had binocular vision with the use of prisms. Diplopia persisted in one patient despite 3 operations. Taking into consideration the interventions done before the patient was referred to us, the reintervention rate was 13 % (95 % CI, 0-28 %). CONCLUSIONS: A binocular field of vision can be successfully restored in the majority of patients with Graves' orbitopathy, using a non-adjustable surgical technique.

Arrêt du Conseil d'Etat du Roi, qui ordonne la réunion de l'imprimerie du Cabinet à l'Imprimerie royale du Louvre et l'établissement d'un détachement de ladite Imprimerie royale à Versailles. Du 23 mai 1789...

[Acte. 1789-03-23]

ABD e-News, January 23, 2004

Weekly newsletter for the State of Iowa Alcoholic Beverages Division

Laurentz, Mme Golding, Decugis, Mme Beamish, 23-11-19, clubiste de tennis : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57030

ABD e-News April 23, 2004

Newsletter for the State of Iowa Alcoholic Beverages Division

23/2/20, bois de Boulogne [promeneurs] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58178

23/2/20, bois de Boulogne [promeneurs] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58177

23/2/20, à l'hôtel Astoria [Paris, place de l'Etoile], M. Jonnart remet ses pouvoirs de président de la commission des réparations : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58170

Lottery Action, February 23-March 7, 2004, Vol. 11, no. 4

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, March 10-23 2003, Vol. 10, no. 5

Iowa Lottery Authority Retailer Information Newsletter

ABD e-News July 23, 2004

Weekly newsletter for the State of Iowa Alcoholic Beverages Division